Dilara BAŞAT DERELİ, Abbase Güleren ALSANCAK

Sülfodiazin, Sülfomerazin ve Sülfometazinin İyonlaşma Sabitlerinin Potansiyometrik Titrasyon Yöntemi ile Tayini

Bu çalışmada sülfonamit grubu ilaçlardan sülfodiazin, sülfomerazin ve sülfometazinin biyolojik sıvılardakiçözünürlük, lipofilisite, asitlik, transfer davranışı, reseptörlere bağlanma ve geçirgenlik gibi özellikleri hakkındakritik bilgiler elde etmemizi sağlayan iyonlaşma sabiti değerleri potansiyometrik titrasyon yöntemiyle tayinedilmiştir. Bileşiklerin suda çözünürlükleri az olması sebebiyle belirli yüzdelerde metanol-su (v/v) ikilikarışımlarında 25oC’de çalışılmış ve verilerin değerlendirilmesinde PKPOT programı ile Gran metodukullanılmıştır. Metanol-su ortamında hesaplanan iyonlaşma sabiti değerlerinden sudaki iyonlaşma sabitideğerlerine geçişte Yasuda- Shedlovsky ekstrapolasyon yöntemi kullanılmıştır. Sülfodiazin için iyonlaşma sabitideğerleri 2,915-6,936; sülfomerazin için 2,734-6,955; sülfometazin için ise 2,466-7,537 olarak bulunmuştur.İyonlaşma sabitlerinin potansiyometrik titrasyon yöntemiyle tayininden elde edilen veriler bu ilaç aktif bileşiklerleçalışan araştırmacılara bilgi kaynağı oluşturacaktır.

Determination of Ionization Constants of Sulfodiazine, Sulfomerazine and Sulfomethazine by Potentiometric Titration Method

In this study, ionization constant values were determined by potentiometric titration method which provides critical information about the properties of sulfodiazine, sulfomerazine and sulfometazine from sulfonamide group drugs such as solubility, lipophilicity, acidity, transfer behavior, binding to receptors and permeability in biological fluids. Because of the low water solubility of the compounds, 40%, 50% and 60% (v/v) methanol-water binary mixtures were studied at 25 °C. Gran method and PKPOT program were used to evaluate the data obtained from these 3 different media. Yasuda-Shedlovsky extrapolation method was used in the transition from ionization constant values calculated in methanol-water media to ionization constant values in water. The ionization constant values for sulfadiazine are 2,915-6,936; 2,734-6,955 for sulfomerazine; and for sulphometazine 2,466-7,537. The data obtained from determination of ionization constants by potentiometric titration method will provide information source for researchers working with this drug active compounds.

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