Akut Pankreatitte Yeni Bir İnflamatuar Belirteç Olarak Ortalama Trombosit Hacmi ve C-Reaktif Protein ile Başvuru Anındaki Ranson Skoru ile İlişkisi

Amaç: Bu çalışmada akut pankreatitli (AP) hastalarda inflamasyon belirteci olarak ortalama trombosit hacmini (MPV) değerlendirmek ve MPV, CRP (C-reactive protein) ile Ranson skoru arasındaki ilişkiyi inceleme amaçlandı. Gereç ve Yöntemler: Bu çalışmaya AP’li 119 hasta (ortalama yaş 53.8 ± 18.0 yıl) ve 88 sağlıklı kontrol grubu (ortalama yaş 53.1 ± 6.8 yıl) alındı. AP’li hastalardan 75’i biliyer AP, 44’ü biliyer olmayan AP olarak sınıflandırıldı. Tüm hastaların demografik verileri, klinik ve laboratuvar bulguları ve Ranson skorları hastanenin veri tabanından incelendi. Bulgular: MPV, AP’li hastalarda kontrol grubuna göre anlamlı olarak daha düşüktü (p = 0.001). AP’li hastalarda CRP, kontrol grubuna göre anlamlı olarak daha yüksekti (p < 0.001). Biliyer ve biliyer olmayan AP grup arasındaki MPV farkı istatistiksel olarak anlamlı bulunmadı. Hastaların hastanede kalış sürelerine göre MPV değerlerini karşılaştırdığımızda anlamlı bir fark yoktu. Korelasyon analizinde CRP, Ranson skoru ve serum MPV seviyeleri arasında korelasyon yoktu. Sonuç: AP grubunda MPV düzeylerinin sağlıklı kontrollere göre daha düşük olduğunu gözlemledik. Bu nedenle, diğer inflamasyon belirteçleri gibi MPV de AP tanısı için yararlı bir belirteç olabilir

Anahtar Kelimeler:

Akut pankreatit, Ortalama trombosit hacmi, inflamasyon

Mean Platelet Volume as a New Inflammatory Marker in Acute Pancreatitis and Its Relation to C-Reactive Protein and Ranson’s Score on Admission

Aim: The study’s aim is to evaluate mean platelet volume (MPV) as a marker of inflammation in patients with acute pancreatitis (AP) and to analyse the relationships among MPV, CRP (C-reactive protein) and Ranson’s score. Material and Methods: In this study, 119 patients with AP (mean age 53.8 ± 18.0 years) and 88 healthy control group (mean age 53.1 ± 6.8 years) were enrolled. Among the patients with AP, 75 were classified as having biliary AP, and 44 were classified as having nonbiliary AP. All patients’ demographic data, clinical and laboratory findings and Ranson’s scores were examined from the hospital’s database. Results: MPV was significantly lower among patients with AP than among the control group (p = 0.001). CRP was significantly higher among patients with AP than among the control group (p< 0.001). The difference in MPV between the biliary and nonbiliary AP group was statistically not significant. When we compared MPV based on patients’ lengths of hospital stay, there was no significant difference. In correlation analysis, there was no correlation among CRP, Ranson’s score and serum MPV levels. Conclusion: We observed that MPV levels in the AP group were lower than healthy controls. Thus, like other inflammation markers, MPV might be a useful marker for AP diagnosis.

Keywords:

Acute pancreatitis, Mean platelet volume, Inflammation,

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