Aysel ŞAHİN KAYA, Tarkan YETİŞYİĞİT, Ahsen YILMAZ, Savaş GÜZEL, Aslı AKYOL MUTLU

Meme Kanseri Hastalarının Kemoterapi Öncesinde, Sırasında ve Sonrasında Beslenme Durumu, Oksidatif Parametreler ve Yaşam Kalitesi İlişkisi

Amaç: Meme kanserli hastalarda kemoterapi (KT) öncesi, sırası ve sonrasında beslenme durumu, oksidatif parametreler ve yaşam kalitesi arasındaki ilişkileri değerlendirilmesi amaçlandı. Gereç ve Yöntemler: KT planlanan meme kanserli hastaların klinik, antropometrik, demografik, yaşam kalitesi, kan oksidatif belirteç düzeyi ve diyet alım verileri kaydedildi. Toplanan tüm veriler, KT öncesi, KT ortası ve KT sonrası zaman noktaları arasında karşılaştırıldı. Bulgular: Çalışmaya meme kanseri tanısı konan ve KT tedavisine başlanacak 50 kadın dahil edildi. KT sonrası vücut ağırlığı ve beden kütle indeksi, KT öncesi değerlerden anlamlı derecede düşüktü (p˂0,001). Her ikisi de KT'nin sonunda toplam günlük kalori ve makro besin alımında bir düşüşle KT öncesi seviyelere döndüler. Belirli gıda gruplarının tüketimi, KT öncesi tüketim düzeylerine göre önemli ölçüde azaldı (p˂0,001). Kan oksidatif stres belirteç analizi, KT ile glutatyon peroksidaz düzeylerinde önemli bir azalma olduğunu ortaya koydu (p=0,007). Yaşam kalitesi puanlarının analizi, KT sonrası puanların KT öncesi puanlardan anlamlı derecede yüksek olduğunu, KT ortasında ise en düşük olduğunu ortaya koydu. Sonuç: Sağlıklı antropometrik ölçümler, oksidatif denge ve yaşam kalitesi sağlamak için bu hastalara KT sırasında diyet danışmanlığı yoluyla yeterli enerji alımı ve antioksidan alımı önerilmelidir.

Anahtar Kelimeler:

Meme kanseri, Kemoterapi, Beslenme durumu, Oksidatif stres, Yaşam kalitesi

Associations of Nutritional Status, Oxidative Parameters, and Quality of Life of Breast Cancer Patients Before, During, and After Chemotherapy

Aim: We aimed to assess the associations between nutritional status, oxidative parameters, and quality of life before, during, and after chemotherapy (CT) in breast cancer patients. Material and Method: Clinical, anthropometric, demographic, quality of life, blood oxidative marker level, and dietary intake data of breast cancer patients who planned to CT were recorded. All collected data were compared between pre-CT, mid-CT, and post-CT time points. Results: Fifty women who were diagnosed with breast cancer and would start CT treatment were included in the study. Post-CT body weight and body mass index were significantly lower than the pre-CT values (p˂0.001). They both turned back to pre-CT levels at the end of CT with a decrease in total daily caloric and macronutrient intake. Consumption of specific food groups significantly decreased compared to their pre-CT consumption levels (p˂0.001). Blood oxidative stress marker analysis revealed a significant reduction in glutathione peroxidase levels with CT (p=0.007). Analysis of the quality-of-life scores revealed that post-CT scores were significantly higher than the pre-CT scores while the life quality was lowest in the mid-CT period. Conclusion: Adequate energy intake and antioxidant intake should be recommended to these patients during CT via dietary counseling to maintain healthy anthropometric measures, oxidative hemostasis, and quality of life.

Keywords:

Breast cancer, Chemotherapy, Nutritional Status, Oxidative stress, Quality of life,

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