Özgür KEMİK, Ahmet PERGEL, Ahu KEMİK SARBAY, Sefa TÜZÜN, Ahmet Fikret YÜCEL

Lipid peroxidation and transforming growth factor-β1 levels in gastric cancer at pathologic stages

Amaç: Yüksek TGF-β1 seviyeleri ve gelişmiş TGF-β1 reseptör sinyalizasyonu mide kanseri patolojisi ile ilişkilidir. Bu etki oksidatif stres ve lipid peroksidasyon ürünleri tarafından oluşmaktadır. Bu çalışmada amaç, mide kanserli hastalarda TGF-β1 ve lipit peroksidasyon ürün düzeylerini ve bu ürünlerin patolojik evre ile korelasyonunu araştırmaktı. Materyal ve Metod: Mide kanserli 50 hasta ve sağlıklı 18 kişinin serumunda lipid peroksidasyon ürün ve TGF-β1 seviyelerine bakıldı. Sonuçlar: T2, T3 ve T4 tümörlü hastaların HNE ve TGF-β1 seviyeleri hem T1 hem de sağlıklı kişilere göre anlamlı derecede yüksek bulundu (p

Objective: High levels of TGF-β1 and enhanced TGF-β1 receptor signaling are related to the pathology of gastric cancer. This effect is caused by oxidative stress and lipid peroxidation products. The aim of this study was to investigate the levels of TGF-β1 and lipid peroxidation products in gastric cancer patients and their correlation with pathologic stage. Material and Methods: Lipid peroxidation products and TGF-β1 levels were studied in the serum samples of 50 gastric cancer patients and 18 control subjects. Results: HNE-protein adducts and TGF-β1 levels were significantly higher in T2, T3 and T4 gastric cancers than in either the T1 stage or controls (p

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