Direk Renin İnhibisyonu

Renal ekstraktlar ile renin anjiotensin sisteminin 1898’de ortaya konmasıyla başlayan tarihi süreci hala şaşırtıcı olmaya devam ediyor. Anjiyotensin dönüştürücü enzim inhibitörleri (ACEI) ve anjiyoten- sin reseptör blokerlerinden (ARB) sonra, son zaman- larda direkt renin inhibitörleri (DRI) de renin anjiyoten- sin alanına girdi. Giderek artan kanıtlarla, renin anji- otensin sistemi inhibisyonu hipertansiyon tadevisinde önemli bir tedavi stratejisidir. Özgün hasta grupları üzerinde ve son organ hasarını korumaya odaklanan sürmekte olan ve gelecekte yapılacak klinik calışma- ların sonuçları, direkt renin inhibisyonu hakkındaki bilgi birikimimizi ve anlayışımızı zenginleştirecektir

Anahtar Kelimeler:

Renin anjiyotensin sistemi, direkt renin inhibitörleri, aliskiren, plazma renin aktivitesi.

Direct Inhibition of Renin

Keywords:

Renin angiotensin system, direct renin inhibitors, aliskiren, plasma renin activity,

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ISSN: 2146-3123
Başlangıç: 2015
Yayıncı: Erkan Mor

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