Şahver Ege HİŞMİOĞULLARI, Adnan Adil HİŞMİOĞULLARI

ETÇİLLERDE KARŞILAŞILAN EKLEM HASTALIKLARINDA MATRİKS METALLOPROTEİNAZLARININ ROLÜ VE SAĞALTIM SEÇENEKLERİ

Eklem hastalıklarında karşılaşılan kıkırdak ve kemik doku yıkımlanmasından sorumlu başlıca maddeler; kollajen ve proteoglikanı yıkımlayan proteinazlardır. Proteolitik enzimlerin 4 ana sınıfı olan aspartik proteinazlar, sistein proteinazlar, serin proteinazlar ve metalloproteinazlar destek dokunun hem normal hareketinde, hem de patolojik yıkımında iş görürler. Bu proteinazlar, eklem içinde farklı hücreler tarafından hazırlanırlar. Her bir enzim, etkilerini durduran, özel protein benzeri inhibitörler tarafından inhibe edilebilir. Son araştırmalar, matriks metalloproteinazlarının eklem hastalıklarındaki birçok sürece karıştığına işaret etmektedirler. Eklem yangılarında (artritis) kıkırdak ve kemiğin yıkımlanması, eklemi normal bir şekilde işlev görmekten alıkoymaktadır. Birçok olayda, eklem yüzeyinin geniş bir bölümü ile birlikte, bu kısmın altındaki kemik de zarar görmüştür. Geleneksel tedaviler, bu hastalığın altında yatan süreçlere çok az etki ederler ve son zamanlarda, proteinaz inhibitörlerinin kullanımı, yeni bir terapötik yaklaşım olarak önerilmektedir. Proteinaz inhibitörleri, model sistemlerde, hastanın kıkırdak yıkımını önleyebilir ve gelecekteki deneysel çalışmalar, bu maddelerin in vivo etkinliklerini ortaya koyabilecektir.

Anahtar Kelimeler:

Matriks metalloproteinazları, Artritis

THE ROLE OF MATRIX METALLOPROTEINASES IN CANINE JOINT DISEASES AND TREATMENT APPROACHES

Proteinases that degrade collagen and proteoglycan are mainly responsible for disintegration of cartilage and bone in joint diseases. Four major classes of proteolytic enzymes which aspartic proteinases, cysteine proteinases, serine proteinases and metalloproteinases perform in normal functioning of connective tissue as well as its pathological destruction. These proteinases prepared by different cells within the joint. Each enzyme may be inhibited by specific protein-like inhibitors which block its effect. The recent research indicate that matrix metalloproteinases involved in many processes in joint diseases. In joint inflammation (arthritis), the degradation of cartilage and bone prevented the joint from functioning in a normal way. In many cases, the large portion of articular surface with underneath bone damaged as well. Conventional therapies have little effect on the underlying processes of this diseases and recently, the use of protease inhibitors proposed as a novel therapeutic approach. In model systems, proteinase inhibitors could prevent cartilage damage in patients and future experimental studies may reveal in vivo activities of these substances.

Keywords:

Matrix metalloproteinases, Arthritis,

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