ANTİMİKROBİYEL PROTEİNLER VE BAĞIŞIKLIKTAKİ ÖNEMİ

Günümüzde antibiyotiklere karşı gelişen direnç yeni antimikrobik etkili kaynakların arayışına yol açmıştır. Bunların arasında üzerinde en fazla araştırma yapılan grup, canlıların doğal bağışıklık sisteminin bir parçası olan antimikrobiyel proteinlerdir. Bu derlemede antimikrobiyel proteinlerin yapıları, etki mekanizmaları ve bağışıklıktaki önemi hakkında bilgi verilmesi amaçlanmaktadır.

ANTIMICROBIAL PROTEINS AND THEIR IMPORTANCE IN IMMUNITY

Developing resistance to antibiotics has led to the search for new effective antimicrobial sources nowadays. The most studied group among these sources is antimicrobial proteins, which are a part of the natural immune system. In this review, it was aimed to give information about the structure and effect mechanisms of antimicrobial proteins, and their importance in immunity.

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  • 1. Carnicelli V., Lizzi A.R., Ponzi A., Amicosante G., Bozzi A.and Di Giulio A. Interaction between antimicrobial peptides (AMPs) and their primary target, the biomembranes. In: Microbial pathogens and strategies for combating them: science, technology and education (A. Méndez-Vilas, Ed.) FORMATEX 2013, pp. 1123-1134.
  • 2. Brogden NK, Brogden KA. Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals? International journal of antimicrobial agents. 2011;38(3):217-225.
  • 3. Brogden K.A., Ackermann M., McCray P.B., Tack B.F.2003. Antimicrobial peptides in animals and their role in host defences. International Journal of Antimicrobial Agents. 2003;22:465-478.
  • 4. Tzeng Y.L., Ambrose K.D., Zughaier S., Zhou X., Miller Y.K., Shafer W.M., Stephens D.S. Cationic antimicrobial peptide resistance in Neissera meningitidis. Journal of Bacteriology. 2005;187(15): 5387-5396.
  • 5. Brogden, KA. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 2005;3:238-250.
  • 6. Anonim. 2016 Erişim adresi: http://www.turkcebilgi.com/antimikrobiyal_peptid Erişim tarihi: 01.12.2016
  • 7. Izadpanah A, Gallo RL. Antimicrobial Peptides. Journal of the American Academy of Dermotology. 2005;52:381-390.
  • 8. Hancock RE. The bacterial outer membrane as a drug barrier. Trends Microbiol. 1997;5:37.
  • 9. Shai Y, Oren Z.From “carpet” mechanism to de-novo designed diastereometric cell-selective antimicrobial peptides, Peptides 2001;22:1629.
  • 10. Palffy R, Garglik R, Behuliak M, Kadasi L, Turna J, Celec P. On the physiology and pathophysiology of antimicrobial peptides. Molecular Medicine, 2009;15(1-2): 51-59.
  • 11. Aksoy B. Derinin doğal bağışıklık sistemi. Türkderm, 2013;47(1):2-11.
  • 12. Wang G. Human antimicrobial peptides and proteins. Pharmaceuticals 2014; 7: 545-594.
  • 13. Koczulla R, Von Degenfeld G, Kupatt C, Krotz F, Zahler S, Gloe T. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. The Journal of Clinical Investigation 2003;111:1665-1672.
  • 14. Ganz T. Defensins: antimicrobial peptides of innate immunity, Nat. Rev. Immunol. 2003;3:710–720.
  • 15. Yamaguchi Y, Ouchi Y. Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases. Proc Jpn Acad Ser B Phys Biol Sci. 2012;88(4):152-66.
  • 16. Frye M, Bargon J, Lembcke B, Wagner TO, Gropp R. Differential expression of human alpha- and beta-defensins mRNA in gastrointestinal epithelia. Eur J Clin Invest 2000; 30: 695-701
  • 17. Şabanoğlu E, Türütoğlu H. Hayvanlarda defensinler ve önemleri. MAE Vet Fak Derg, 2016;1 (1): 29-39.
  • 18. Bals, R. Epithelial antimicrobial peptides in host defense against infections. Respiratory Research. 2000;1:141-150
  • 19. Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity J. Leukoc. Biol. 2004; 753948.
  • 20. Gürpınar S, Kırhan Ş. Antimikrobiyel Peptidler. İstanbul Üniv. Vet.Fak.Derg. 2010; 36(2):61-66.
  • 21. Kaspar AA, Okada S, Kumar J, Poulain FR, Drouvalakis KA, Kelekar A. A distinct pathway of cell-mediated apoptosis initiated by granulysin. The Journal of Immunology. 2001;167:350-356.
  • 22. Yılmaz B. Tosun H. Sütte Bulunan Doğal Antimikrobiyal Sistemler ve Bunların Gıda Sanayinde Kullanımı. C.B.Ü. Fen Bilimleri Dergisi. 2012;8(1):11-20.
  • 23. Avcı G. Laktoferrinin Biyolojik Özellikleri ve Hastalıklarla İlişkisi, Afyon Kocatepe Üniversitesi Fen Bilimleri Dergisi, 2007;7(1): 23-34.
  • 24. Berlutti F, Pantanella F, Natalizi T, Frioni A, Paesano R, Polimeni A, Valenti P. Antiviral properties of lactoferrin--a natural immunity molecule. Molecules. 2011;16(8):6992-7018
  • 25. Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, Loukopoulos D, Camaschella C. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nature Genet. 2003; 33:21-22.
  • 26. Rossi E. Hepcidin-the iron regulatory hormone. Clin Biochem Rev. 2005;26(3):47-49
  • 27. Anderson GJ, Darshan D, Wilkins SJ, Frazer DM. Regulation of systemic iron homeostasis: how the body responds to changes in iron demand. Biometals 2007; 20:665-74.
  • 28. Ganz T. Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Practice & Research Clinical Haematology, 2005;18 (2):171-82.