Ege AĞIRMAN, Bahar Marangoz, Mehmet Ziya Gençer, Seçil Arıca, Kübra Zegerek

Tip 2 Diyabetli Hastalarda Oral Anti Diyabetik İlaçların HBA1c, Obezite ve Komplikasyonlar ile İlişkisi

Amaç: Tip 2 diyabetes mellitus hastalarının kullandıkları oral anti diyabetik tedavilerin glisemik kontrol, vücut kitle indeksi ve komplikasyonlarla ilişkisinin değerlendirilmesi.Yöntem: Okmeydanı Eğitim ve Araştırma Hastanesi Aile Hekimliği Poliklinikleri’ne başvuran 18 yaş ve üzeri tip 2 diyabet tanılı hastalardan son 6 aydır tek başına ya da kombinasyon şeklinde oral anti diyabetik kullanan, gönüllü 270 hasta çalışmaya alındı. Bozulmuş açlık glukozu ve/veya bozulmuş glukoz toleransı olan hastalar, insülin kullanan hastalar çalışmaya dahil edilmedi. Karşılaştırmalarda t testi ve ki kare analizleri kullanıldı. P<0,05 anlamlı kabul edildi.Bulgular: Katılımcıların %46,7 si erkek, %53,3 ü kadın olup grubun yaş ortalaması 53.9 (±0.7)’dur. 270 hastadan 82’sinin (%30,4) kan şekerinin regüle olduğu, 188’inin (%69,6) kan şekerinin regüle olmadığı saptandı. Kan şekeri regüle olan grupta her üç kişiden birinde mikrovasküler komplikasyon saptanırken; regüle olmayan grupta bu oran daha yüksek tespit edildi. Kan şekeri regüle olmayanlarda daha fazla makrovasküler komplikasyon görüldüğü gözlendi. Kan şekeri regüle olanların çoğunlukla tek ve/veya ikili ilaç kullandığı, regüle olmayanların ikiden fazla ilaç kullandığı saptandı. Sonuç: Çok sayıda oral anti diyabetik tedavi seçenekleri bulunmasına karşın önemli sayıda diyabetik hasta kötü glisemik kontrol, obezite ve bunun bir sonucu olarak komplikasyonlar ile yaşama riski altındadır.

Anahtar Kelimeler:

oral anti diyabetik, tip 2 diabetes mellitus, vücut kitle indeksi, komplikasyon

The Relationship between Oral Anti Diabetic Drugs with HBA1c, Obesity and Complications in Type 2 Diabetic Patients

Objective: Evoluation of oral anti diabetic medication used by type 2 diabetes mellitus patients in relation to glycemic control, body mass index and complications.Methods: 270 volunteer patients, over 18 years of age, who applied to Family Medicine Clinics of Okmeydanı Training and Research Hospital, diagnosed with type 2 diabetes who were taking oral anti diabetic drugs for the last 6 months alone or in combination were taken to study. Patients with impaired fasting glucose and/or impaired glucose tolerance, patients using insulin were not included in the study. In the comparison, t-test and chi-square analyzes were used. P <0.05 was considered significant.Results: 46.7% of the participants were male, 53.3% were female and the average age of the group was 53.9 (± 0.7). 82 of 270 patients (30.4%) were found to have regular blood sugar and 188 (69.6%) were not found to have regular. Microvascular complications were detected in one of three individuals in the regular blood glucose group; this rate was higher in the irregular group. More macrovascular complications were observed in the irregular blood glucose group. It was revealed that those who have regular blood sugar mainly used single and/or dual drugs, those who have irregular blood sugar use more than double drugs. Conclusion: Despite the large number of oral anti diabetic treatment options, a significant number of patients with tip 2 diabetes mellitus are under the risk of living with poor glycemic control, obesity, and complications

Keywords:

oral anti diyabetic, tip 2 diabetes mellitus, body mass ındex, complication,

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