Hakan Aydın, Zülfükar Bilge, Abdullah Algın, Hüseyin Avni Fındıklı, Bünyamin Aydın

Çölyak hastalığı ile komplike nadir görülen otoimmün poliglandüler sendrom; tip3B

Otoimmün poliglandüler sendrom (OPS) farklı otoimmün hastalıkların kombinasyonudur. Klinik kriterler baz alınarak OPS'nin dört ana tipi tariflenmiştir.Tip 3 formu; Addison hastalığı olmadan, otoimmün tiroid hastalıklarından birine Tip 1 diabetes mellitus (Tip 3A) veya kronik atrofik gastrit, pernisiyöz anemi, çölyak hastalığı, otoimmün hepatit (Tip 3B), vitiligo,alopesi,myastenia graves (Tip 3C), kollajen hastalıklar, vaskülit (Tip 3D) gibi otoimmün hastalıkların eşlik ettiği sendromdur. Çölyak hastalığı (CD), güçlü bir genetik etkiye sahip immün aracılı bir hastalıktır. Tip 1 diabetes mellitus (T1DM) ve OTH, insanların bu hastalıklardan etkilendiği ve Çölyak hastalığı gelişimi için yüksek risk taşıyan iyi tanımlanmış iki hastalıktır. Burada T1DM ve OTH tanıları ile beraber Çölyak hastalığı ile komplike olmuş 32 yaşında kadın bir hastayı yani OPS Tip 3B sendromunu sunmaktayız.

Anahtar Kelimeler:

Otoimmün poliglandüler sendrom, Çölyak hastalığı, Tip 1 diabetes mellitus, Otoimmün tiroid hastalığı

Rarely seen autoimmune polyglandular syndrome; Type 3B complicated with celiac disease

Autoimmune polyglandular syndrome (APS) is a combination of different autoimmune diseases. APS type 3 is defined by the presence of autoimmune thyroid disease (ATD) without Addison’s disease and at least one autoimmune disease such as type 1 diabetes mellitus (type 3A), chronic atrophic gastritis, pernicious anemia,autoimmune hepatitis or celiac disease (type 3B), vitiligo, alopecia, myasthenia gravis (type 3C), autoimmune rheumatic disorders, vasculitis (type 3D). Celiac disease (CD) is an immune-mediated disease with a strong genetic influence. Type 1 diabetes mellitus (T1DM) and ATD are well established and people suffering from these two diseases are considered at high risk of developing CD. Here we present a rarely seen case of a 32-year-old woman with T1 DM and ATD complicated with CD, which is defined APS type 3B.

Keywords:

Autoimmune polyglandular syndrome, Celiac disease, Type 1 diabetes mellitus, Autoimmune thyroid disease,

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