DUT (Morus spp.) BİTKİSİNİN BİOAKTİF BİLEŞENLERİ

Yapılan çalışmalar insan sağlığının korunmasında ve hastalıkların önlenmesinde üzümsü meyvelerin oldukça önemli rolleri olduğunu göstermektedir. Bu meyvelerin insan sağlığı üzerine olumlu etkileri içermiş oldukları bioaktif bileşenlerden kaynaklanmaktadır. Bu bileşenlerce zengin meyve türlerinden biri de duttur (Morus spp.). Dut meyveleri güçlü antioksidan özellik gösteren antosiyaninlerce zengindir. Başlıca antosiyaninler; akciğer kanser hücrelerinin istilasını engelleyici etkiye sahip olduğu rapor edilen siyanidin-3-glikozid ve siyanidin-3-rutinozid ile siyanidin-3-sophorosid, pelargonidin-3-glikozid ve pelargonidin-3-rutinozid'dir. Ayrıca dut meyvesi bol miktarda şeker, vitamin C ve organik asit içermektedir. Dut yaprakları güçlü bir ?-glikozid engelleyicisi olarak bilinen 1-deoksinojirimycin içermektedir. Bu nedenle Asya ülkelerinde diyabet hastaları antihiperglisemik gıda olarak dut yaprak çaylarını kullanmaktadır. Bu çalışmada farklı dut türlerinin fitokimyasal içerikleri ve antioksidant aktiviteleri üzerine yapılan çalışmalar incelenerek, derlenmiştir

BIOACTIVE COMPOUNDS OF MULBERRY (Morus spp.)

BIOACTIVE COMPOUNDS OF MULBERRY (Morus spp.) Studies show that berries have very important role in the prevention of disease and the protection of human health. These positive effects on human health of the fruits are resulted from bioactive compounds. One of the fruits, are rich based on that compound, is mulberry. Mulberry fruit is very rich in regard to anthocyanin having a strong antioxidant effect. Major anthocyanin is siyanidin–3–sophorosid, pelargonidin–3–glikozid, elargonidin–3–rutinozid, siyanidin–3–glikozid and siyanidin–3–rutinozid. It was reported that siyanidin–3–glikozid and siyanidin–3–rutinozid are effective on prevention of lung cancer. In addition, mulberry fruits contain high amounts of sugar, vitamin C and organic acids. Mulberry leaves contain 1–deoksinojirimycin known as a powerful α–glycoside blocker. Therefore, people with diabetes in Asian Countries use mulberry leaf tea as anti–hyperglycemic food. Previous studies interested in bioactive content and antioxidant activity of different mulberry species were reviewed in the study

___

  • 1. Abbas, G. M., F. M. A. Bar, H. N. Baraka, A. A. Gohar and M. F. Lahloub, 2014. A New Antioxidant Stilbene and Other Constituents from The Stem Bark of Morus nigra L. Natural Product Research 28(13):952–959.
  • 2. Abbasi, A. M., M. H. Shah, G. XinBo and N. Khan, 2016. Comparison of Nutritional Value, Antioxidant Potential, and Risk Assessment of The Mulberry (Morus) Fruits. International Journal of Fruit Science 16(2):113–134.
  • 3. Akın, M., S. P. Eyduran, S. Erçişli, I. Yılmaz and O. Çakır, 2016. Phytochemical Profiles of Wild Grown Blackberry and Mulberry in Turkey. Acta Sci. Pol. Hortorum Cultus, 1581:3–12.
  • 4. Ali, A. and M. Ali, 2013. New Triterpenoids from Morus alba L. Stem Bark. Natural Product Research 27(64):524–531.
  • 5. Anwar, F., S. Kanwal, G. Shabir, K. M. Alkharfy and A. H. Gilani, 2015. Antioxidant and Antimicrobial Attributes of Different Solvent Extracts from Leaves of Four Species of Mulberry. International Journal of Pharmacology 11(7):757–765.
  • 6. Butkhup, L., W. Samappito and S. Samappito, 2013. Phenolic Composition and Antioxidant Activity of White Mulberry (Morus alba L.) Fruits. International Journal of Food Science & Technology 48(5):934–940.
  • 7. Chauhan, S., S. C. Verma and R. V. Kumar, 2013. Evaluation of Phytochemical and Anti– Oxidant Activity in Different Mulberry Varieties. Asian Journal of Chemistry (4): 8010–8014.
  • 8. Chian–Yei, L. and L. Horng Liang, 2013. Characteristics of Fruit Growth, Component Analysis and Antioxidant Activity of Mulberry (Morus spp.). Scientia Horticulturae 162:285–292.
  • 9. Calin–Sanchez, A., J. J. M. Nicolas, S. Munera–Picazo, A. A. Carbonell–Barrachina, P. Legua and F. Hernandez, 2013. Bioactive Compounds and Sensory Quality of black and White Mulberries Grown in Spain. Plant Foods Hum Nutr. 68:370–377.
  • 10.DaSong, Y., L. ZiLei, Y. YongPing, Z. WeiLie and L. XiaoLi, 2015. A New Geranylated 2–Arylbenzofuran from Morus alba. Chinese Herbal Medicines 7(2):191– 194.
  • 11.De–Wu., Z., T. Xiao–Yu, Y. Li–Yan and D. Jun–Gui, 2015. New 2–arylbenzofuran Metabolite From Cell Cultures of Morus alba. Journal of Asian Natural Products Research 17(6):683–688.
  • 12.Du, Q., J. Zheng and Y. Xu, 2008. Composition of Anthocyanins in Mulberry and Their Antioxidant Activity. Journal of Food Composition and Analysis 21:390–395.
  • 13.Ercişli, S. and E. Orhan, 2007. Chemical Composition of White (Morus alba), Red (Morus rubra) and Black (Morus nigra) Mulberry Fruits. Food Chem. 103:1380–1384.
  • 14.Ercişli, S. and E. Orhan, 2008. Some Physico– Chemical Characteristics of Black Mulberry (Morus nigra L.) Genotypes from Northeast Anatolia Region of Turkey. Scientia Horticulturae 116:41–46.
  • 15.Eyduran, S. P., S. Erçişli, M. Akın, O. Beyhan, M. K. Geçer, E. Eyduran and Y. E. Ertürk, 2015. Organik Acids, Sugars, Vitamin C, Antioksidant Capacity, and Phenolic Compounds in Fruits of White (Morus alba L.) and Black (Morus nigra L.) Mulberry Genotypes. Journal of Applied Botany and Food Quality 88:134–138.
  • 16.Fozing, C. D. A., Z. Ali, B. T. Ngadjui, M. I. Choudhary, G. D. W. F. Kapche, B. M. Abegaz and I. A. Khan, 2012. Phosphodiesterase I–Inhibiting Diels–Alder Adducts from the Leaves of Morus mesozygia. Planta Medica 78(2):154–159.
  • 17.Gecer, M. K., M. Akın, M. Gündoğdu, S. P. Eyduran, S. Ercişli and E. Eyduran, 2016. Organic Acids, Sugars, Phenolic Compounds, and Some Horticultural Characteristics of Black and White Mulberry Accessions from Eastern Anatolia. Canadian Journal of Plant Science 96(1):27–33.
  • 18.Gözlekçi, S., H. I. Uzun and A. Yeğin, 2015. Some Physico–Chemical Characteristics of Mulberry (Morus alba, Morus laevigata, Morus nigra) Species Grown in Western. Acta Horticulturae 1106:191–197.
  • 19.Gündoğdu, M., F. Muradoğlu, R. I. G. Sensoy and H. Yılmaz, 2011. Determination of Fruit Chemical Properties of Morus nigra L., Morus alba L. and Morus rubra L. by HPLC. Scientia Horticulturae 132:37–41.
  • 20.Hunyadi, A., A. Martins, T. J. Hsieh, A. Seres and I. Zupko, 2012. Chlorogenic Acid and Rutin Play a Major Role in The in vivo Anti– Diabetic Activity of Morus alba Leaf Extract on Type II Diabetic Rats. Plos One 7(11):1–6.
  • 21.Iqbal, S., U. Younas, C. Sirajuddin, R. A. KimWei, R. A. Sarfraz and K. Uddin, 2012. Proximate Composition and Antioxidant Potential of Leaves from Three Varieties of Mulberry (Morus sp.): A Comparative Study. International Journal of Molecular Sciences 13(6):6651–6664.
  • 22.Imran, M., H. Khan, M. Shah, R. Khan and F. Khan, 2010. Chemical Composition and Antioxidant Activity of Certain Morus Species. Journal of Zhejiang University (Science B) 11(12):973–980.
  • 23.JaeWoo, J., K. WonMin, P. JiHae, S. KyeongHwa, O. EunJi, L. DaeYoung, L. DongSung, K. YounChul, L. DongWook, H. DaeSeok and B. Namin, 2015. Isoprenylated Flavonoids from The Root Bark of Morus alba and Their Hepatoprotective and Neuroprotective Activities. Archives of Pharmacal Research 38(11):2066–2075.
  • 24.JiHae, P., J. YeJin, J. JaeWoo, S. Shrestha, H. DaeSeok, L. DongWook and B. NamIn, 2015. Two New Isoarylbenzofuran Diglucosides from The Root Bark of Morus alba. Journal of Asian Natural Products Research 17(4): 357–363.
  • 25.Jing, Q., F. Min, H. Juan, W. XingDe, P. LiYan, S. Jia, C. Xiao, L. Yan, K. LingMei, L. RongTao and Z. QinShi, 2015. New Cytotoxic and Anti–Inflammatory Compounds Isolated from Morus alba L. Natural Product Research 29(18):1711–1718.
  • 26.Jin, Z., L. ShunXiang, W. Wei, G. XiaoYi, L. XiangYang, Y. XinPei, H. Dan, W. BaoYang and C. Liang, 2013. Variations in The Levels of Mulberroside a Oxyresveratrol and Resveratrol in Mulberries in Different Seasons and During Growth. The Scientific World 2013:1–8.
  • 27.Khattak, K. F. and T. R. Rahman, 2015. Effect of Geographical Distributions on The Nutrient Composition, Phytochemical Profile and Antioxidant Activity of Morus nigra. Pakistan Journal of Pharmaceutical Sciences 28(85):1671–1678.
  • 28.Khalid, N., S. A. Fawad and I. Ahmed, 2011. Antimicrobial Activity, Phytochemical Profile and Trace Minerals of Black Mulberry (Morus nigra L.) Fresh Juice. Pak. J. Bot. 43:91–96.
  • 29.Katsube, T., N. Imawaka, Y. Kawano, Y. Yamazaki, K. Shiwaku and Y. Yamane, 2006. Antioxidant Flavonol Glycosides in Mulberry (Morus alba L.) Leaves Isolated Based on LDL Antioxidant Activity. Food Chemistry 97:25–31.
  • 30.Kostic, D. A., D. S. Dimitrijevic, S. S. Mitic, M. N. Mitic, G. S. Stojanovic and A. V. Zivanovic, 2013. Phenolic Content and Antioxidant Activities of Fruit Extracts of Morus nigra L. (Moraceae) from Southeast Serbia Tropical. Journal of Pharmaceutical Research 12(1):105–110.
  • 31.Kumar, S. and A. K. Pandey, 2013. Chemistry and Biological Activities of Flavonoids: An Overview. The Scientific World Journal Article 2013:1–16.
  • 32.Kumar, R. S., D. Painuly, A. Shukla, J. Singh, A. Porval and S. Vats, 2014. In vitro Biological Activity and Total Phenolic Content of Morus nigra Seeds. Journal of Chemical and Pharmaceutical Research 6(11):200–210.
  • 33.Linneaus, C., 1753. Species Plantarum. Stockholm, Sweden, 986p.
  • 34.Linghong, L., W. Xiangyang, Z. Maomao, Z. Weiguo, L. Fang, Z. Ye and Y. Liuqing, 2012. Chemical Composition, Nutritional Value, and Antioxidant Activities of Eight Mulberry Cultivars from China. Pharmacogn Mag. 8(31):215–224.
  • 35.Mahmoud, M. Y., 2013. Matural Antiokxidants Effect of Mulberry Fruits (Morus nigra and Morus alba L.) on Lipids Profile and Oxidative Stress in Hypercholestrolemic Rats. Pakistan Journal of Nutrition 12(7):665–672.
  • 36.ManhTuan, H., T. ManhHung, A. KimJeong, J. KyungJin, K. JaeWang, K. WookDong, C. WooJae, W. MiHee, R. SungHo and M. ByungSun, 2016. Potential Pancreatic Lipase İnhibitory Activity of Phenolic Constituents from The Root Bark of Morus alba L. Bioorganic & Medicinal Chemistry Letters 26 (12): 2788–2794.
  • 37.Memon, A. A., N. Memon, D. L. Luthria, M. I. Bhanger and A. A. Pitafi, 2010. Phenolic Acids Profiling and Antioxidant Potential of Mulberry (Morus laevigata w., Morus nigra L., Morus alba L.) Leaves and Fruits Grown in Pakistan. Pol. J. Food Nutr. Sci, 60(1):25– 32.
  • 38.Meng, W., Y. BangWei, Y. MeiHua, G. LiXin, L. JingYa, W. HeYao, L. Jia and H. AiJun, 2015. New Isoprenylated Phenolic Compounds from Morus laevigata. Chemistry & Biodiversity 128(6):937–945.
  • 39.Miljkovic, V. M., G. S. Nikolic, L. B. Nikolic and B. B. Arsic, 2014. Morus Species Through Centuries in Pharmacy and as Food. Advanced Technologies 3(2): 111–115.
  • 40.Natic, M. M., D. C. Dabic, A. Papetti, M. M. F. Aksic, V. Ognjanov, M. Ljubojevic and Z. L. Tesic, 2015. Analysis and Characterisation of Phytochemicals in Mulberry (Morus alba L.) Fruits Grown in Vojvodina, North Serbia. Food Chemistry 171: 128–136.
  • 41.Okcu, Z. ve F. Keleş, 2009. Kalp–Damar Hastalıkları ve Antioksidanlar. Atatürk Üniv. Ziraat Fakültesi Dergisi 40(1):153–160.
  • 42.Özgen, M., S. Serçe and C. Kaya, 2009. Phytochemical and Antioxidant Properties of Anthocyanin–Rich Morus nigra and Morus rubra Fruits. Scientia Horticulturae 119:275– 279.
  • 43.Pan, Z., N. Gang, T. YanFeng, S. GuoRu, Z. ChunLei, C. RuoYun, C. XiaoGuang and Y. DeQuan, 2015. Two New Flavonoids from Morus notabilis. Journal of Asian Natural Products Research 17(9):888–892.
  • 44.Perez–Gregorio, M. R., J. Regueiro, E. Alonso–Gonzalez, L. M. Pastrana–Castro and J. Simal–Gandara, 2011. Influence of Alcoholic Fermentation Process on Antioxidant Activity and Phenolic Levels from Mulberries (Morus nigra L.). Food Science and Technology 44:1793–1801.
  • 45.Ping–Hsiao, S., C. Yin–Ching, L. Jiunn– Wang, W. Ming–Fu and Y. Gow–Chin, 2010. Antioxidant and Cognitive Promotion Effects of Anthocyanin–Rich Mulberry (Morus atropurpurea L.) on Senescence–Accelerated Mice and Prevention of Alzheimer’s Disease. Journal of Nutritional Biochemistry 21:598– 605.
  • 46.Pothinuch, P. and S. Tongchitpakdee, 2011. Melatonin Contents in Mulberry (Morus spp.) Leaves: Effects of Sample Preparation, Cultivar, Leaf, Age and Tea Processing. Food Chemistry 128:415–419.
  • 47.Qing, J., Y. JiuFang, M. LiYan, C. JieLing and L. JingMing, 2015. Comparison of Polyphenol Profile and Inhibitory Activities Against Oxidation and α–Glucosidase in Mulberry (genus Morus) Cultivars from China. Journal of Food Science 80(11):2440– 2451.
  • 48.Radojkovic, M. M., Z. P. Zekovic, S. S. Vidovic, D. D. Koçar and P. Z. Maskovic, 2012. Free Radical Scavenging Activity and Total Phenolic and Flavonoid Contents of Mulberry (Morus spp. L., Moraceae) Extracts. Hemijska Industrija 66(4):547–552.
  • 49.Raman, S. T., A. K. P. G. Ganeshan, C. Cheng, J. Chao, L. ShaoHui, C. HuiJuan and G. ZhongZheng, 2016. In vitro and in vivo Antioxidant Activity of Flavonoid Extracted from Mulberry Fruit (Morus alba L.). Pharmacognosy Magazine 12(46):128–133.
  • 50.Sağlam, S., 2007. Antosiyanince Zengin Dut, Kiraz ve Gilaburu Meyvelerindeki Fenolikler ve Antioksidan Kapasitesi Üzerine Reçel Yapım İşleminin Etkisi (Yüksek Lisans Tezi). S.Ü. Fen Bil. Enst. Gıda Mühendisliği Ana Bilim Dalı, Konya.
  • 51.Thabti, I., N. Marzougui, W. Elfalleh and A. Ferchichi, 2011. Antioxidant Composition and Antioxidant Activity of White (Morus alba L.), Black (Morus nigra L.) and Red (Morus rubra L.) Mulberry Leaves. Acta Botanica Gallica 158(2):205–209.
  • 52.Vavilov, N. I., 1951. The Origin, Variation, Immunity and Breeding of Cultivated Plants. Chronica Botanica 13:1–366.
  • 53.Vijayan, K. and S. N. Chatterjee, 2003. ISSR Profiling of Indian Cultivars of Mulberry (Morus spp.) and its Relevance to Breeding Programs, Euphytica 131: 53–63.
  • 54.Wawro, A., D. Pieprzyk–Kokocha, A. Gryszczynska, Z. Lowicki, P. L. Mikolajczak and K. Grajek, 2013. Comparison of The Composition of The Polyphenol Content in The Hydroalcoholic Extracts Leaves of Different Varieties of White Mulberry (Morus alba L.). Postepy Fitoterapii 4:220–224.
  • 55.WeiChiang, C., L. PhuiYan and W. SiuKuin, 2016. Phytochemistry, Pharmacology and Clinical Trials of Morus alba. Chinese Journal of Natural Medicines 14(1):17–30
  • 56.Xiao, H., W. JinWei, W. Meng, Y. MeiHua, Z. QinShi, W. HeYao and H. AiJun, 2012. 2– Arylbenzofuran, Flavonoid and Tyrosinase Inhibitory Constituents of Morus yunnanensis. Journal of Natural Products 75(1):82–87.
  • 57.Xin, W., K. Jie, W. HongQing, L. Chao, L. BaoMing and C. RuoYun, 2014. Three New Alkaloids from the Fruits of Morus alba. Journal of Asian Natural Products Research 16(5):453–458.
  • 58.Yan, Y., Z. Ting, X. Lei and C. RuoYun, 2010. Two Novel Flavanes from The Leaves of Morus alba L. Journal of Asian Natural Products Research 12(3/4):194–198.
  • 59.Yang, Y., Y. Tan, R. Chena and J. Kanga, 2014. The Latest Review on The Polyphenols and Their Bioactivities of Chinese Morus Plants. Journal of Asian Natural Products Research 16(6):690–702.
  • 60.YaLong, Z., L. JianGuang, W. ChuanXing, Z. ZhongBo and K. LingYi, 2015. Four New Flavonoids with α–Glucosidase Inhibitory Activities from Morus alba var. tatarica. Chemistry & Biodiversity 12(11):1768–1776.
  • 61.Yiğit, D., A. Mavi and M. Aktaş, 2008. Antioxidant Activities of Black Mulberry (Morus nigra). Ege Üniv. Fen Bilimleri Enstitüsü Dergisi 1(2):223–232.
  • 62.ZhongFei, Z., Z. QingJian, C. RuoYun and Y. DeQuan, 2012. Four New Flavonoids from Morus australis. Journal of Asian Natural Products Research 14(3):263–269.
Bahçe-Cover
  • ISSN: 1300-8943
  • Yayın Aralığı: Yılda 2 Sayı
  • Başlangıç: 1968
  • Yayıncı: Atatürk Bahçe Kültürleri Merkez Araştırma Enstitüsü
Sayıdaki Diğer Makaleler

FRENK ÜZÜMÜ ÇELİKLERİNİN KÖKLENMESİ ÜZERİNE ÇELİK ALMA ZAMANLARININ ETKİSİ

Mehmet POLAT, Volkan OKATAN, Ünzile VAROL

BAZI BİTKİ BESİN ELEMENT UYGULAMALARININ 'RUBYGEM' ÇİLEK ÇEŞİDİNDE VERİM VE KALİTE ÜZERİNE ETKİLERİ

Mehmet Ali SARIDAŞ, Sevgi KARGI PAYDAŞ, Gözde NOGAY, Şule Hilal ATTAR², Ebru KAFKAS³

KUŞBURNU’NDA (Rosa montana Chaix subsp. woronovii (Lonacz) Ö. Nilsson L.) ÇEKİRDEKSİZ MEYVE OLUŞUMU VE MEYVE ÖZELLİKLERİ ÜZERİNE FARKLI HORMON DOZLARININ ETKİLERİ

Öznur ÖZ ATASEVER, Resul GERÇEKCİOĞLU

BAZI HÜNNAP GENOTİPLERİNİN ÇELİKLERİNİN KÖKLENMESİ ÜZERİNE ÇELİK ALMA ZAMANI VE IBA UYGULAMALARININ ETKİLERİ

Mehmet POLAT, Adnan Nurhan YILDIRIM

SİVAS İLİ ULAŞ İLÇESİNDE YETİŞTİRİLEN BAZI ÇİLEK ÇEŞİT VE TİPLERİNİN PERFORMANSLARININ BELİRLENMESİ

Ali İSLAM, Nafia ÇERÇİ, Aslı ÇOTALA

BAZI ÜZÜMSÜ MEYVELERDE TOPLAM FENOL VE ANTİOKSİDAN AKTİVİTE İÇERİKLERİNİN BELİRLENMESİ

Ayşegül BURGUT², Hatice ÖZCAN², Özgecan TÜREMİŞ³, Begüm OLUT, Nurgül F TÜREMİŞ, Ebru KAFKAS

HİCAZNAR (Punica granatum L.) NAR ÇEŞİDİNDE MEYVELERİN BİYOKİMYASAL İÇERİKLERİ ÜZERİNE LOKASYON VE RAKIMIN ETKİSİ

Fatma YILDIRIM, Ahmet GÜLER

UŞAK İLİ ÜZÜMSÜ MEYVE YETİŞTİRİCİLİĞİNİN BELİRLENMESİ

Ayşen Melda ÇOLAK, Yasin ÇETİN

GÜZYEMİŞİ (Elaeagnus umbellata Thunb.) ÇELİKLERİNDE KÖKLENME ÜZERİNE ÇELİK ALMA ZAMANI VE IBA DOZLARININ ETKİSİ

Hüseyin ÇELİK, Damla ÇELİK

PEYZAJ TASARIMINDA ALTERNATİF BİR MEYVE AĞACI: Arbutus unedo L.

Elif BOZDOĞAN, Sema GÜLER, Ayşegül BURĞUT