Yeliz ULAŞ, Veysel TOLAN, Ahmet İsmail ÖZKAN

Yeni p-alkilaminofenol Bileşiklerinin Sentezi ve Antimikrobiyal ve Antioksidan Aktivitelerinin Araştırılması

Alkilaminofenoller antikanser aktivitelerine sahip iyi bilinen organik yapılardır. Bu çalışmada, yüksek verimlerle petasis reaksiyonuyla bir seri (4,5,6) alkilaminofenol bileşiği sentezlendi. Sentezlenen bileşikler ${}^{-1}H-NMR;and;{}^{13}C-NMR$ ile karakterize edildi. Ardından,bu bileşiklerin antimikrobiyal ve antioksidan aktivitelerini incelendi. Elde edilen bileşikler, Gram pozitif ve Gram negatif bakterilere karşı test edildi. 4 nolu bileşiğin , 10 mg / mL konsantrasyonda antimikrobiyal aktivite gösterirken, 6 nolu bileşiğin, S. aureus'ta aktivite gösterdiği görüldü. Fenolik bileşikler proksimal ve antioksidan aktivitelerinden dolayı dikkat çekici yapılardır. Alkilaminofenoller fenolik yapıya sahip olduklarından antioksidan aktiviteleri de araştırılmıştır. Diyabete, kalp hastalığına ve kansere karşı yüksek antioksidan kapasiteye sahip ilaç aktif maddeleri; ilk kez sentezlenmiştir.

Synthesis of New p-Alkylaminophenol Compounds and Investigation of Their Antimicrobial and Antioxidant Activity

Alkylaminophenols are synthetic derivatives well known for their anticancer activity. In this work, we report the antimicrobial andantioxidant activity of such compounds. A series (4,5,6) of alkylaminophenol compounds were prepared with fairly good yields byPetasis reaction. Synthesized compounds were characterized by ${}^{-1}H-NMR;and;{}^{13}C-NMR$. The obtained compounds were tested againstGram-positive and Gram-negative bacteria. The compound 4 showed antimicrobial activity at a concentration of 10 mg/mL, while the6 compound showed activity on S. aureus. Phenolic compounds have attracted attention due to their proximal and antioxidant activities.Since alkylaminophenols have phenolic structure, their antioxidant activity has been investigated. Thus, drug-active substances withhigh antioxidant capacity against diabetes, heart disease, and cancer were synthesized.

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