Role of Protein Oxidation, Lipid Peroxidation and Antioxidant Defense Systems on Diabetes Mellitus

Abstract: Diabetes; is a chronic disease whose prevalence has been increasing day by day in the world. Severalmechanisms have been causing the formation of diabetes. One of these mechanisms is the oxidative stress thatoccurs in cells and tissues. Oxidative damage which is caused by reactive oxygen species; has an important rolein the formation of complications due to diabetes. Hyperglycemia caused by diabetes increases free radicalformation. The antioxidant defense system tries to balance the toxic effects of reactive oxygen species. A, C, Evitamins and glutathione is Non-enzymatic antioxidants, and superoxide dismutase, catalase, glutathione peroxidaseand glutathione reductase is enzymatic antioxidants against reactive oxygen species. In this study; the balancebetween antioxidants and free radicals, the role of oxidative stress in diabetes and possible therapeutic effectswill be examined.

Keywords:

Malondialdehyde, Oxidative damage, Free radicals Antioxidant defense,

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Ayala, A., Muñoz, MF., Argüelles, S. (2014). Lipid peroxidation: production, metabolism and signaling mechanisms of malondialdehydeand 4-hydroxy-2-nonenal. Oxidative Medicine and Cellular Longevity, 2014,1-31.
Butterfield, DA., Koppal, T., Howard, B., Subramaniam, R., Hall, N., Hensley, K., Yatin, S., Allen, K., Aksenov, M., Aksenova, M., Carney, J. (1998). Structural and functional changes in proteins induced by free radicalmediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E. Annals of the New York Academy of Sciences, 854, 448–462.
Büyükgüzel, E. (2013). Protein Oksidasyonun Biyokimyasal ve Moleküler Mekanizması, Karaelmas Science and Engineering Journal, 3(1), 40-51.
Cai, H. and Harrison, DG. (200). Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circulation Research, 87(10), 840– 844.
Chesemann, K H. and Slater, T F. (1993). An introduction to free radical biochemistry. British Medical Bulletin, 49, 481-493.
Coleman, MD., Fernandes, S., Khanderia, L. (2003). A preliminary evaluation of a novel method to monitor a triple antioxidant combination (vitamins E, C and α-lipoic acid) in diabetic volunteers using in vitro methaemoglobin formation. Environmental Toxicology and Pharmacology, 14(1-2), 69-75.
Cunningham, JJ., Mearkle, PL., Brown, RG. (1994). Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. The Journal of the American College of Nutrition, 13(4), 344-350.
Drews, G., Krippeit-Drews, P., Düfer, M. (2010). Oxidative stress and beta-cell dysfunction. European Journal of Physiology, 460(4), 703–718.
Eriksson, J., Kohvakka, A. (1995). Magnesium and ascorbic acid supplementation in diabetes mellitus. Annals of Nutrition and Metabolism, 39(4), 217–223.
Evans, JL., Goldfine, ID., Maddux, BA., Grodsky, GM. (2003). Are oxidative stress activated signaling pathways mediators of insulin resistance and cell dysfunction? Diabetes, 52(1), 1–8.
Gezginci, S., Basaraner, H., Yanardag, R., Bolkent, S. (2009). The effects of combined treatment of antioxidants on the liver injury in STZ diabetic rats. Digestive Diseases and Sciences, 54(3), 538–546.
Giugliano, D., Ceriello, A., Paolisso, G. (1995). Diabetes mellitus, hypertension and cardiovascular diseases: which role for oxidative stress? Metabolism, 44, 363–368.
Ha, H., Kim, KH. (1999) Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C. Diabetes Research and Clinical Practice, 45(2-3), 147–151.
Haskins, K., Bradley, B., Powers, K., Fadok, V., Flores ,S., Ling, X., Pugazhenthi, S., Reusch, J., Kench, J. (2003). Oxidative stress in type 1 diabetes. Annals of the New York Academy of Sciences, 1005, 43–54.
Jeffcoate, SL. (2004). Diabetes control and complications: the role of glycated haemoglobin, 25 years on. Diabetic Medicine, 21(7), 657-665.
Julius, U., Pietzsch, J. (2005). Glucose-induced enhancement of hemin-catalyzed LDL oxidation in vitro and in vivo. Antioxidants & Redox Signaling, 7(11-12), 1507-1512.
Khan, A., Petropoulos, IN., Ponirakis, G., Malik, RA. (2017). Visual complications in diabetes mellitus: beyond retinopathy. Diabetic Medicine, 34(4), 478-484.
Levine, R L., Williams, J A., Stadtman, E R. and Shacter, E. (1994). Carbonyl assays for determination of oxidatively modified proteins. Methods in Enzymology, 233, 346-357.
Maritim, AC., Sanders, RA., Watkins, JB.(2003). Diabetes, oxidative stress, and antioxidants: a review. Journal of Biochemical and Molecular Toxicology, 17(1), 24–38.
Masella, R., Benedetto, RD., Varı, R., Filesi, C., Giovannini, C. (2005). Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathionerelated enzymes. Journal of Nutritional Biochemistry, 16, 577–586.
Memişoğluları, R., Bakan, E. (2004). Levels of ceruloplasmin, transferrin, and lipid peroxidation in the serum of patients with Type 2 diabetes mellitus. Journal of Diabetes and Its Complications, 18, 193– 197.
Memişoğluları, R., Taysi, S., Bakan, E., Capoglu, I. (2003). Antioxidant Status and Lipid Peroxidation in Type II Diabetes Mellitus. Cell Biochemistry and Function, 21, 291-296.
Mowri, HO., Frei, B., Keaney, JF. (200). Glucose enhancement of LDL oxidation is strictly metal ion dependent. Free Radical Biology and Medicine, 29(9), 814-824.
Niki, E., Yoshida, Y., Saito, Y., Noguchi, N. (2005). Lipid peroxidation: Mechanisms, inhibition, and biological effects. Biochemical and Biophysical Research Communications, 338, 668–676.
Paolisso, G., D’Amore, A., Giugliano, D., Ceriello, A., Varricchio, M., D’Onofrio, F. (1993). Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. The American Journal of Clinical Nutrition, 57(5), 650-656.
Peavy, DE., Taylor, JM., Jefferson, LS. (1985). Time course of changes in albumin synthesis and mRNA in diabetic and insulin treated diabetic rats. American Journal of Physiology, 248(6), 656–663.
Rocha Fernandes, J., Ogurtsova, K., Linnenkamp, U., Guariguata, L., Seuring, T., Zhang, P., Cavan, D., Makaroff, LE. (2016). IDF Diabetes Atlas estimates of 2014 global health expenditures on diabetes. Diabetes Research and Clinical Practice, 117, 48-54.
Rosen, P., Du, XL., Tschope, D. (1998). Role of oxygen derived radicals for vascular dysfunction in the diabetic heart: prevention by alpha-tocopherol? Molecular and Cellular Biochemistry, 188(1-2), 103–111.
Seifried, HE., Anderson, DE., Fisher, EI., Milner, JA. (2007). A review of the interaction among dietary antioxidants and reactive oxygen species. The Journal of Nutritional Biochemistry, 18(9), 567–579.
Sertçelik, M., Sugeçti, S., Büyükgzel, E., Necefoğlu, H., Büyükgüzel K. (2018). Toxicological and Physiological Effects of Diaquabis(N,N-diethylnicotinamide-x N1)bis(4- formylbenzoato- x O)cobalt(II) complex on Galleria mellonella L. (Lepidoptera: Pyralidae) as a model organism. Karaelmas Science and Engineering Journal, 8(1), 359-364.
Shah, D., Mahajan, N., Sah, S., Nath, S., Paudyal, B. (2014). Oxidative stress and its biomarkers in systemic lupus erythematosus. Journal of Biomedical Science, 21(1), 23.
Sugeçti, S. and Büyükgüzel, K. (2017). Chromatographic Methods Used in the Determination of Oxidative DNA Damage Biomarker 8-Hydroxy 2-Deoxyguanosine, Relationship Between Oxidative Damage and Aging and Cancer. 6.Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi, Adana, Turkey, pp. 115.
Sugeçti, S., Büyükgüzel, E., Büyükgüzel K. (2016). Laboratory assays of the effects of oxfendazole on biological parameters of Galleria mellonella (Lepidoptera: Pyralidae). Journal of Entomological Science, 51(2), 129-137.
Tabei, SM., Fakher, S., Djalali, M., Javanbakh,t MH., Zarei, M., Derakhshanian, H., Sadeghi, MR., Mostafavi, E., Kargar, F. (2015). Effect of vitamins A, E, C and omega-3 fatty acids supplementation on the level of catalase and superoxide dismutase activities in streptozotocin-induced diabetic rats. Bratislava Medical Journal, 116(2), 115-8.
Tiedge, M., Lortz, S., Drinkgern, J., Lenzen, S. (1997). Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin producing cells. Diabetes, 46(11), 1733– 1742.
Vincent, AM., Russell, JW., Low, P., Feldman, EL. (2004). Oxidative Stress in the Pathogenesis of Diabetic Neuropathy. Endocrine Reviews, 25, 612–628.
West IC. (2000). Radicals and oxidative stress in diabetes. Diabetic Medicine, 17(3), 17171–17180.
Wolff, SP. (1993). Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. British Medical Bulletin, 49(3), 642-652.
Yin, H., Xu, L., Porter, NA. (2011). Free radical lipid peroxidation: mechanisms and analysis. Chemical Reviews, 111, 5944- 5972.
Young, IS., Woodside, JV. (2001). Antioxidants in health and disease. Journal of Clinical Pathology, 54, 176-186.