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Metallotiyoninlerin Histofizyolojik önemi

Metallotiyoninler (MT) düşük molekül ağırlıklı (6000-7000 Da), 20 sistein molekülü içeren 61 amino asitli hücre içi proteinlerdir. MT proteini çinko, bakır, kadmiyum, civa, kurşun gibi metalleri bağlama yeteneğine sahiptir. Bu proteinler akciğer, böbrek, pankreas ve karaciğerin paranşimal hücrelerinde, barsakların epitellerinde, sertoli hücrelerinde, timulin içeren timus epitel hücrelerinde, germinatif hücrelerde, miyoepitel hücrelerinde normal olarak bol miktarda bulunmaktadır. MT’lerin önemi; ağır metallerin ve iz elementlerin homeostazisinde, detoksifikasyonunda ve taşınmasında görev almasıdır. Ayrıca, MT’ler hem hücrelerin gelişmesinde hem de apoptozis ve nekrozis gibi hücre ölümleriyle de ilşkileri bulunmaktadır.

Histophysiological importance of Metallothioneins

Metallothioneins (MTs) are are a family of small (61 amino acids), cysteine-rich (20 residues) low-molecular-weight (6000–7000 Da) intracellular proteins.The MT proteins can be bound metal ions such as zinc, copper, cadmium, mercury, and lead. They are found in normal tissues such as myoepithelial cells, germinative cells, thymulin-containing thymic epithelial cells, Sertoli cells, epithelial cells of bowel, and parenchymal cells of liver, pancreas, kidney, and lung. Significant of the MTs are roles in heavy-metal homeostasis, detoxification, and transport such as Zn, Cu, Hg, Pb and Cd. Moreover, MTs are associated both cell proliferation and cell death such as necrosis and apopitosis
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Atatürk Üniversitesi Veteriner Bilimleri Dergisi-Cover
  • ISSN: 1306-6137
  • Yayın Aralığı: Yılda 3 Sayı
  • Yayıncı: Atatürk Üniversitesi Veteriner Fakültesi
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