First Detection of Hypomyelination Associated with Bovine Viral Diarrhoea Virus in an Aborted Calf in Gumushane Region

Bu çalışmada, Holstein Friesian ırkı bir buzağıda görülen hidranensefali ve orta şiddette serebellar hipoplazi olgusu makroskobik, mikroskobik ve immunohistokimyasal yönden incelenmiştir. Merkezi sinir sisteminde meydana gelen histopatolojiler ise Sığırların Virüsi İshali Virüsü (SVİV) ile ilişkili immunohistokimyasal olarak ortaya konuldu. Histopatolojik olarak, perivasküler kanama, ödem, nöronal nekroz ve dejenerasyonlar gösterildi. İmmünohistokimyasal olarak, SVİV antijenleri nöron, glial hücreler ve endotel hücrelerde gösterildi. Anılan vaka, Gümüşhane bölgesinde SVİV ile ilişkili olarak meydana gelen aborte bir Holstein Friesian buzağının ilk raporu olma özelliği taşımaktadır. Bu bulgu, Gümüşhane bölgesi için epidemiyoloji ve SVİV enfeksiyonlarının denetim gerekliliğinin ciddiyetini de gösterebilir

Gümüşhane Bölgesinde Aborte Bir Buzağıda Sığır Viral Diyare Virusu ile İlişkili Hipomyelinasyon’un İlk Tespiti

In this study, hydranencephaly and mild cerebellar hypoplasia were reported macroscopically, microscopically and immunohistochemically in an aborted Holstein Friesian calf. A relationship between Bovine Viral Diarrhoea Virus (BVDV) infection and histopathology associated with the central nervous system (CNS) lesions were demonstrated. In the histopathology, perivascular haemorrhage, oedema, neuronal necrosis and degeneration were observed in the CNS. BVDV positive immunoreaction was detected in neurons, glial and endothelial cells of CNS by immunohistochemical examination. As far as the authors are concerned, this is the first report of BVDV present in an aborted Holstein Friesian Calf in Gumushane region. This finding may have important implications for the epidemiology and control of BVDV infection in the Gumushane region

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