Mehmet AYDİN, Mehmet Kürşat KARADAĞ, Mehmet Hakan ŞAHİN, Mete ZEYNAL, Ali AHISKALIOĞLU, Osman Nuri KELEŞ, Sevilay ÖZMEN

Nöro-enterik Şelalenin Şarj Edici Etkisinin Azalmasıyla Gelişen Zayıflamış Subtalamik Çekirdek Elektromanyetik Alan Şiddetinin Parkinson Hastalığındaki Nöro Fiziksel Rolü: Öncü Deneysel Çalışma

Amaç: Subtalamik çekirdek stimülasyonunun (STN) nörofiziksel mekanizması hala belirsiz olsa da, azalan elektrik alan gücü ile STN pil ile yeniden şarj edilebilir. Einstein'ın tanımladığı yasaya göre, elektrik yüklü Auerbach gangliyonlarının bağırsak hareketleriyle birlikte titreşerek oluşturduğu birleşik elektromanyetik alan (UF) enerjisi, afferent sinirler tarafından pil gibi beyni şarj etmek üzere taşınabilir. Bu çalışma, mevcut teorinin rasyonelliğini incelemektedir. Gereç ve Yöntem: Bu çalışmada 360±20 gr ağırlığındaki 18 rat, intestinal pulsasyon aralıklarına göre 10±3/GI; 7±2/GII ve 3±1/GIII olmak üzere 3 grubua bölündü. Çıkan kolon orta hattından 5 farklı mesafeden 10 mm aralıklarla 0,5 mm kesitler alınarak Auerbach ganglion yoğunluğu (n/AG/mm3), Auerbach ganglion nöron yoğunluğu (n/AGN/mm3) hesaplandı ve STN nöron yoğunlukları (n/STN/mm3) tahmin edildi. Titreşen parçacıklar olarak kabul edilen Auerbach ganglia nöronlarının sayıları (VPN/mm3), VPN=nAxnAG; Auerbach ganglionlarının oluşturduğu birleşik alan kuvveti (UFS) değerleri, UFS=fxVPN denklemi ile olacak şekilde tahmin edildi. UFS ve n/STN değerleri Mann Witney U testi ile karşılaştırıldı. Bulgular: VPN/UFS/nSTN değerleri: (13.345±2.143)/(11.146±1.689)/132.863±12.654 GI'de; (11.762±1.843)/(8.434±1.119)/121.371±9.872 GII'de ve (8.659±903)/(7.109±768) /118.127±6942 GIII'de) UFS/nSTN arasındaki istatistiksel sonuçlar: p

Anahtar Kelimeler:

Parkinson hastalığı, subtalamik çekirdek, tek alanlı alan, Auerbach ganglionları, nöroenterik şelale

Neuro Physical Mechanism Of Parkinson Disease Linked With Weak Electromagnetic Field of Subthalamic Nucleus Induced By Decreased Charging Effect Of Neurenteric Coil: Preliminary Experimental Study

Objective: Although the neurophysical mechanism of subthalamic nucleus (STN) stimulation is still unclear, STN with decreasing electric field strength may be re-charged by battery. According to the law defined by Einstein, the unified electromagnetic field (UF) energy formed by the electrically charged Auerbach ganglia co-oscillating with bowel movements, can be transported by afferent nerves to charge the brain, like as battery. This study examines the rationality of the current theory. Methods: In this study, 18 rats with 360±20 gr weighted were divided into 3 groups according to their intestinal pulsation ranges as: 10±3/GI; 7±2/GII and 3±1/GIII. Auerbach's ganglia density (n/AG/mm3), Auerbach ganglia neuron density (n/AGN/mm3) were estimated by taking 0.5 mm sections at 10 mm intervals from 5 different distances from the midline of the ascending colon; and STN neuron densities (n/STN/mm3) were estimated. The Auerbach ganglia neurons -accepted as vibrating particles- numbers (VPN/mm3) estimated with: VPN=nAxnAG; the unified field strength (UFS) values formed by Auerbach's ganglia was estimated by UFS=fxVPN equation. UFS and n/STN values were compared Mann Witney U test. Results: VPN/UFS/nSTN values were: (13.345±2.143)/(11.146±1.689)/132.863±12.654 in GI; (11.762±1.843)/(8.434±1.119)/121.371±9.872 in GII and (8.659±903)/(7.109±768) /118.127±6942 in GIII) Statistical results between UFS/nSTN were found as: p

Keywords:

Parkinson disease, subthalamic nucleus, unifield field, Auerbach ganglia, Neurenteric coil Parkinson hastalığı, subtalamik çekirdek, tek alanlı alan, Auerbach ganglionları, nöroenterik şelale,

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