Sevilay ÖZMEN, Funda DEMİRAĞ, Sare ŞİPAL

Akciğer Adenokarsinomlarında Patern Analizi ve Derecelendirme

Adenokarsinom, akciğer kanserinin en sık görülen histolojik tipidir. tedavi seçimi artık bütünsel olarak histolojik fenotipe ve moleküler genotipe bağlıdır. Akciğer adenokarsinomunun onkolojisi, moleküler biyolojisi, patolojisi, radyolojisi ve cerrahisindeki ilerlemeleri ele almak için, 2011 yılında Uluslararası Akciğer Kanseri Araştırmaları Derneği, Amerikan Toraks Derneği ve Avrupa Solunum Derneği tarafından uluslararası bir multidisipliner sınıflandırma yapıldı. 2015 yılında, sınıflandırmayı daha doğru hale getirmek için immünohistokimyanın kullanılması özellikle vurgulandı. 2021 DSÖ akciğer tümörlerinin sınıflandırılması güncellendi. Klinik, patolojik ve moleküler olarak heterojen olan bu tümörlerin multidisipliner bir yaklaşıma dayanan teşhisinde önce immünohistokimya ve ardından moleküler tekniklerle desteklenen morfoloji esastır. Bu derlemede Akciğer adenokarsinomlarının heterojen morfolojisine odaklanmaktadır

Anahtar Kelimeler:

Akciğer, Adenokarsinom, Patern Analizi, Derecelendirme

Pattern Analysis and Grading in Lung Adenocarcinomas

Adenocarcinoma is the most common histological type of lung cancer. The choice of treatment now holistically depends on the histological phenotype and molecular genotype. To address advances in the oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was made in 2011 by the International Society for Lung Cancer Research, the American Thoracic Society, and the European Respiratory Society. In 2015, special emphasis was placed on the use of immunohistochemistry to make classification more accurate. Updated 2021 WHO classification of lung tumors. In the diagnosis of these tumors, which are clinically, pathologically and molecularly heterogeneous, based on a multidisciplinary approach, morphology supported first by immunohistochemistry and then by molecular techniques is essential. This review focuses on the heterogeneous morphology of Lung adenocarcinomas

Keywords:

lung, adenocarcinoma, pattern analysis, grading,

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