MASTEKTOMİ SONRASI GELİŞEN LENFÖDEM VE TEDAVİ YAKLAŞIMI

Lenfödem; primer olarak subkutan dokuda ve subfasial tabakada plazma proteinlerinin, ekstravaskuler kan elemanlarının, immunglobulin ve sitokinlerin olduğu sıvının anormal miktarda birikimi ile karakterize bir durumdur. Lenfatik taşıma kapasitenin üstünde sıvı birikimi veya yetersiz lenfatik transport sonucu lenfödem tablosu oluşur. Lenfödem kronik progresif bir hastalıktır. Dolayısıyla erken tanı ve tedavi oluşabilecek komplikasyonları (disabilite, enfeksiyon, depresyon, ağrı, malign transformasyon) önlemek adına önemlidir. Tedavinin temelini manuel lenfatik drenaj diye adlandırılan özel bir masaj tekniği, cilt bakımı, kompresyon bandajı ve egzersizler oluşturmaktadır. Lenfödem için uygulanan egzersizler genellikle; remedial egzersizler, kuvvetlendirme egzersizleri, aerobik egzersizler ve germe egzersizleridir. Verilecek egzersiz programıda kişiye özel düzenlenmelidir.

LYMPHODEMA DEVELOPING AFTER MASTECTOMY AND THE TREATMENT APPROACH

Lymphedema is a condition characterized by abnormal accumulation of fluid containing plasma proteins, extravascular blood elements, immunoglobulins and cytokines, primarily in the subcutaneous tissue and subfascial layer. Lymphedema occurs as a result of fluid accumulation above the lymphatic carrying capacity or insufficient lymphatic transport. Lymphedema is a chronic progressive disease. Therefore, early diagnosis and treatment are important to prevent complications (disability, infection, depression, pain, malignant transformation). The basis of the treatment is a special massage technique called manual lymphatic drainage, skin care, compression bandage and exercises. Exercises applied for lymphedema are generally; remedial exercises, strengthening exercises, aerobic exercises and stretching exercises. The exercise program to be given should be tailored to the individual.

___

  • Referans 1. Türkiye Cumhuriyeti Sağlık Bakanlığı, organlara göre kanser sıklığının dağılımı ve kadınlarda en sık görülen 10 kanser, http://www.saglik. gov.tr/extras/statistics 2001. Ulaşım Tarihi:07.11.2006.
  • Referans 2. Paskett ED, Stark N. Lymphedema: Knowledge, treatment, and impact among breast cancer survivors. Breast J. 2000;6:373-8
  • Referans 3. Szuba A, Achalu R, Rockson SG. Decongestive lymphatic therapy for patients with breast carcinoma-associated lymphedema. A randomized, prospective study of a role for adjunctive intermittent pneumatic compression. Cancer 2002;95:2260-7.
  • Referans 4. Petrek JA, Pressman PI, Smith RA. Lymphedema: Current issues in research and management. CA Cancer J Clin. 2000;50:292-307.
  • Referans 5. DiSipio T, Rye S, Newman B, Hayes S. Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. The lancet oncology. 2013;14(6):500-15.
  • Referans 6. Chiu T. Management of secondary lymphoedema. Hong Kong Med J. 2014;20(6):519-28.
  • Referans 7. Van der Veen P, De Voogdt N, Lievens P, Duquet W, Lamote J, Sacre R. Lymphedema development following breast cancer surgery with full axillary resection. Lymphology. 2004;37(4):206.
  • Referans 8. Goffman TE, Laronga C, Wilson L, Elkins D. Lymphedema of the arm and breast in irradiated breast cancer patients: risks in an era of dramatically changing axillary surgery. The breast journal. 2004;10(5):405-11.
  • Referans 9. Shaitelman SF, Chiang Y-J, Griffin KD, DeSnyder SM, Smith BD, Schaverien MV, et al. Radiation therapy targets and the risk of breast cancer-related lymphedema: a systematic review and network metaanalysis. Breast cancer research and treatment. 2017;162(2):201-15.
  • Referans 10. Uzkeser H, Karatay S, Erdemci B, Koc M, Senel K. Efficacy of manual lymphatic drainage and intermittent pneumatic compression pump use in the treatment of lymphedema after mastectomy: a randomized controlled trial Breast Cancer. 2015 May;22(3):300-7. doi: 10.1007/s12282-013-0481-3
  • Referans 11. Feldman J, Stout N, Wanchai A, Stewart B, Cormier JN, Armer J. Intermittent pneumatic compression therapy: a systematic review. Lymphology. 2012;45(1):13-25.
  • Referans 12. Carati CJ, Anderson SN, Gannon BJ, Piller NB. Treatment of postmastectomy Mastektomi sonrası… Uzkeser H. lymphedema with low‐level laser therapy: a double blind, placebo‐controlled trial. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2003;98(6):1114-22.
  • Referans 13. Akınoğlu B. Plantar Fasiit Te Radyal Ekstrakorporeal Şok Dalga Tedavisi ve Ultrasontedavisinin Etkinliğinin Karşılaştırılması. 2015.
  • Referans 14. Kwan ML, Cohn JC, Armer JM, Stewart BR, Cormier JN. Exercise in patients with lymphedema: a systematic review of the contemporary literature. Journal of Cancer Survivorship. 2011;5(4):320-36.
  • Referans 15. Fialka-Moser V, Korpan M, Varela E, Ward A, Gutenbrunner C, Casillas JM, Delarque A, Berteanu M, Christodoulou N. The role of physical and rehabilitation medicine specialist in lymphoedema. Ann Phys Rehabil Med. 2013 Jul;56(5):396-410. doi:10.1016/j.rehab.2013.03.002.
  • Referans 16. Jeffs E, Wiseman T. Randomised controlled trial to determine the benefit of daily homebased exercise in addition to self-care in the management of breast cancer-related lymphoedema: a feasibility study. Support Care Cancer. 2013 Apr;21(4):1013-23. doi: 10.1007/s00520-012-1621-6.
  • Referans 17. Bicego D, Brown K, Ruddick M, Storey D, Wong C, Harris SR. Exercise for women with or at risk for breast cancer-related lymphedema. Phys Ther. 2006 Oct;86(10):1398-405. doi: 10.2522/ptj.20050328.
  • Referans 18. Lane KN, Dolan LB, Worsley D, McKenzie DC. Upper extremity lymphatic function at rest and during exercise in breast cancer survivors with and without lymphedema compared with healthy controls. J Appl Physiol (1985). 2007 Sep;103(3):917-25. doi: 10.1152/japplphysiol.00077.2007.
  • Referans 19. Yeşil H, Eyigör S. Lenfödem Tedavisinde Egzersizlerin Yeri. Türkiye Klinikleri 2016; 9(4):77-85
  • Referans 20. Sayko O, Pezzin LE, Yen TW, Nattinger AB. Diagnosis and treatment of lymphedema after breast cancer: a population-based study. PM R. 2013 Nov;5(11):915-23. doi: 10.1016/j.pmrj.2013.05.005.
  • Referans 21. Cheema BS, Kilbreath SL, Fahey PP, Delaney GP, Atlantis E. Safety and efficacy of progressive resistance training in breast cancer: a systematic review and metaanalysis. Breast Cancer Res Treat. 2014 Nov;148(2):249-68. doi: 10.1007/s10549- 014-3162-9.
  • Referans 22. Schmitz KH, Troxel AB, Cheville A, Grant LL, Bryan CJ, Gross CR, et al. Physical Activity and Lymphedema (the PAL trial): assessing the safety of progressive strength training in breast cancer survivors. Contemp Clin Trials 2009 May;30(3):233-45
  • Referans 23. Cormie P, Pumpa K, Galväo D, Turner E, Spry N, Saunders C. Is it safe and efficacious for women with lymphedema secondary to breast cancer to lift heavy weights during exercise: a randomized controlled trial. J Cancer surviv. 2013 Sep;7(3):413-24. doi: 10.1007/s11764-013-0284-8.
  • Referans 24. Katz E, Dugan NL, Cohn JC, Chu C, Smith RG, Schmitz KH.Weight lifting in patients with lower-extremity lymphedema secondary to cancer: a pilot and feasibility study. Arch Phys Med Rehabil. 2010 Jul;91(7):1070-6. doi: 10.1016/j.apmr.2010.03.021.
  • Referans 25. Hayes SC, Reul-Hirche H, Turner J.Exercise and secondary lymphedema: safety, potential benefits, and research issues. Med Sci Sports Exerc 2009;41(3):483-9.
  • Referans 26. Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, Ladha AB, Proulx C, Vallance JK, Lane K, Yasui Y, McKenzie DC. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial J Clin Oncol. 2007 Oct 1;25(28):4396-404.doi: 10.1200/JCO.2006.08.2024.
  • Referans 27. Boing L, do Bem Fretta T, de Carvalho Souza Vieira M, Pereira GS, Moratelli J, Sperandio FF, Bergmann A, Baptista F, Dias M, de Azevedo Guimarães AC.Pilates and dance to patients with breast cancer undergoing treatment: study protocol for a randomized clinical trial – MoveMama study. Trials. 2020 Jan 7;21(1):35. doi:10.1186/s13063-019-3874-6.