Solid Tümörlerde Hematopoetik Kök Hücre Nakli

Güncel, riske dayalı multimodal tedavi şemalarıyla çocukluk çağı lenfomaları ve solid tümörlerinde kabul edilebilir sonuçlar alınmaktadır. Özellikle lenfomalarda genel sağkalım % 90 ve üzerine çıkmıştır. Çocukluk çağında solid tümörlü hastalarda hematopoetik kök hücre nakli ile ilgili prospektif randomize çalışmaların bulunmayışı nedeniyle EBMT kayıtları önemli bir kaynak oluşturmaktadır. İdeal olarak, kök hücre nakli ile ilgili kararların yüksek riskli nöroblastomda olduğu gibi prospektif çalışmalara dayandırılması gerekmektedir. Bu çalışmada, güncel literatür bilgileri esas alınarak çocukluk çağında solid tümörlü hastalarda kök hücre nakli ile ilgili endikasyon ve sonuçlar kısaca gözden geçirilmiştir.

Anahtar Kelimeler:

Hematopoetik kök hücre nakli, lenfomalar, solid tümörler, çocuklar

Hematopoietic Stem Cell Transplantation in Solid Tumors

Children suffering from lymphomas and solid tumors have acceptable outcome with current risk adapted multimodality treatment. Especially, in lymphomas overall survival rates have reached the 90% level or higher. Because of the rarity of randomized prospective trials on hematopoietic stem cell transplantation in children with solid tumors the EBMT registry remains an important source of information. Decisions for hematopoietic stem cell transplantation should ideally be based on prospective trials like in high-risk neuroblastoma. In this study, indications and results of the hematopoietic stem cell transplantation in children with solid tumors was reviewed shortly in light of current literature.

Keywords:

Hematopoietic stem cell transplantation, lymphomas, solid tumors, children,

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