Allojenik Hematopoietik Kök Hücre Transplantasyonunda Hazırlık Rejimleri

Allojenik hematopoetik kök hücre transplantasyonunda (HKHT) hazırlık rejimlerinin yeri çok önemlidir. hazırlık rejimlerinin amacı hastayı transplantasyona hazırlamaktır. Hazırlık rejimleri başlıca üç temel nedenle uygulanmaktadır: ‘yeni kemik iliğine yer açmak’, ‘immünsupresyon’ ve ‘hastalık eradikasyonu’. Hazırlık rejimi seçerken hastalığı eradike edecek, engraftmanı sağlayacak, en az toksisiteye neden olacak, o hasta için en uygun hazırlık rejimine karar verilmelidir. Hazırlık rejimlerinin uygulanmasındaki hatalar çok ciddi, hatta fatal sonuçlar doğurabilir. Bu nedenle allojenik HKHT’nda hazırlık rejimleri çok dikkatli bir şekilde seçilmeli ve uygulanmalıdır.

Anahtar Kelimeler:

Hazırlık rejimleri, Allojenik, Hematopoetik kök hücre transplantasyonu

Conditioning Regimens in Allogeneic Hematopoietic Stem Cell Transplantation

Conditioning plays a central role in allogeneic hematopoietic stem cell transplantation (HSCT). The aim of the conditioning regimen in allogeneic HSCT is to prepare the patient for its transplantation. Conditioning regimen is given with three main objectives: 'creation of space', 'immunosuppression' and 'disease eradication'. Optimal conditioning regimen will eradicate the disease, enable engraftment, and cause little toxicity for the patient. Errors in its application may have serious or even fatal consequences. Then, conditioning regimens should be carefully applied in allogeneic HSCT.

Keywords:

Conditioning regimens, Allogeneic, Hematopoietic stem cell transplantation,

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