Oküler Graft Versus Host Hastalığı

Allojenik hematopoetik kök hücre nakli (allo-HKHN), hematolojik malignitelerin tedavisinde önemli bir terapötik yöntemdir. Graft-versus-host hastalığı (GVHH), allo-HKHN sonrası morbidite ve mortalitenin sık görülen bir nedenidir. GVHH'nın ciddi sistemik formu hayatı tehlit edebilir. GVHH'nın göz tutulumu ise uzun dönemdeki morbiditenin en yaygın nedenidir.Bu derleme makalede, oküler GVHH'nın etyolojisi, patofizyolojisi, klinik özellikleri ve tedavi seçenekleri sunulmaktadır.

Anahtar Kelimeler:

Oküler Graft Versus Host hastalığı, kuru göz

Ocular Graft Versus Host Disease

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important therapeutic procedure for the treatment of hematologic malignancies. Graft-versus-host disease (GVHD) is a common cause of morbidity and mortality after allo-HSCT. Severe systemic form of GVHD may become life threatening. Ocular involvement of GVHD remains the most common cause of long-term morbidity.In this review article, the etiology, pathophysiology, clinical features, and treatment modalities of ocular GVHD are presented.

Keywords:

Ocular Graft Versus Host Disaese, dry eye,

PDF

___

Bacigalupo A. Management of acute graft-versus-host disease. Br J Heamatol. 2007;137:87-98. Arora M, Klein JP, Weisdorf DJ, Hassebroek A, Flowers ME, Cutler CS et al. Chronic GVHD risk score: a Center for International Blood and Marrow Transplant Research analysis. Blood. 2011;117:6714-20.
Aoki S, Mizote H, Minamoto A, Suzuki M, Mishima HK, Tanaka H. Systemic FK506 improved tear secretion in dry eye associated with chronic graft versus host disease. Br J Ophthalmol. 2005;89:243-4.
Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet. 2009;373:1550-61.
Shikari H, Antin JH, Dana R. Ocular graft-versus-host disease: a review. Surv Ophthalmol. 2013;58:233-51.
Shulman HM, Sullivan KM, Weiden PL, McDonald GB, Striker GE, Sale GE. Chronic graft-versus host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med. 1980;69:204-17.
Bray LC, Carey PJ, Proctor SJ. Ocular complications of bone marrow transplantation. Br J Ophthalmol. 1991;75:611-4.
Franklin RM, Kenyon KR, Tutschka PJ, Saral R, Green WR, Santos GW. Ocular manifestations of graft-vs-host disease. Ophthalmology. 1983;90:4-13.
Hirst LW, Jabs DA, Tutschka PJ, Green WR, Santos GW. The eye in bone marrow transplantation. I. Clinical study. Arch Ophthalmol. 1983;101:580-4.
Anderson NG, Regillo C. Ocular manifestations of graft versus host disease. Curr Opin Ophthalmol. 2004;15:503-7.
Ogawa Y, Okamoto S, Wakui M, Watanabe R, Yamada M, Yoshino M. Dry eye after haematopoietic stem cell transplantation. Br J Ophthalmol. 1999;83:1125-30.
Ogawa Y, Kuwana M. Dry eye as a major complication associated with chronic graft-versus-host disease after hematopoietic stem cell transplantation. Cornea. 2003;22:19-27.
Kim SK. Update on ocular graft versus host disease. Curr Opin Ophthalmol. 2006;17:344-8.
Jabs DA, Hirst LW, Green WR, Tutschka PJ, Santos GW, Beschorner WE. The eye in bone marrow transplantation. II. Histopathology. Arch Ophthalmol. 1983;101:585-90.
Janin A, Facon T, Castier P, Mancel E, Jouet JP, Gosselin B. Pseudomembranous conjunctivitis following bone marrow transplantation: immunopathological and ultrastructural study of one case. Hum Pathol. 1996;27:307-9.
Hettinga YM, Verdonck LF, Fijnheer R, Rijkers GT, Rothova A. Anterior uveitis a manifestation of graft-versus-host disease. Ophthalmology. 2007;114:794-7.