Mikrokimerizm ve Meme Kanseri

Breast cancer is one of the most common types of cancer in the world. Microchimerism is one of the subject that has been studied about breast cancer. Microchimerism is the finding of DNA and cells of two different individuals together in a person. Conditions such as organ transplantation, blood transfusion, pregnancy, childbirth or breastfeeding lead to the DNA and cell passage between two different individuals. It is known that the cells which passed to the mother from fetus during pregnancy can live for long years in the mother's body. Microchimeric cells as without any effect in the human body, are able to cause autoimmune diseases or play a role in tissue regeneration. Microchimeric cells can inhibit or slow down the development of certain diseases or cancers with the role they play in tissue regeneration. In this review, the effect of microchimerism on breast cancer genesis was examined.

Microchimerism and Breast Cancer

Meme kanseri dünya üzerinde en sık görülen kanser türleri arasında yer almaktadır. Meme kanseri ile ilgili çalışılan konulardan birisi de mikrokimerizmdir. Mikrokimerizm, farklı iki bireye ait DNA ve hücrelerin bir arada tek bir kişide bulunmasıdır. Organ transplantasyonu, kan nakli, gebelik, doğum ya da emzirme gibi durumlar, iki farklı birey arasında DNA ve hücre geçişinin, diğer bir deyişle mikrokimerizmin oluşumuna yol açar. Gebelik sırasında fetüsten anneye geçen hücrelerin, annenin vücudunda uzun yıllar yaşayabildiği bilinmektedir. Mikrokimerik hücreler, yıllarca insan vücudunda hiçbir etki yapmadan kalabildiği gibi, otoimmün hastalıklara neden olabilmekte ya da doku rejenerasyonunda rol oynayabilmektedir. Mikrokimerik hücreler, doku rejenerasyonunda oynadıkları rolle bazı hastalıkların ya da kanserin gelişimini önleyebilmekte veya yavaşlatabilmektedir. Bu derlemede, mikrokimerizmin meme kanseri oluşumu üzerine etkisi incelenmiştir

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ISSN: 1300-3755
Yayın Aralığı: Yılda 4 Sayı
Başlangıç: 1992
Yayıncı: Çukurova Üniversitesi Tıp Fakültesi

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