Çocukluk Çağında Akut Myeloid Lösemi

Akut lösemiler, akut lenfoblastik lösemi ve akut myeloid lösemi (AML) olarak temelde ikiye ayrılmaktadır. Çocukluk çağı lösemilerinin yaklaşık %15-20’sini AML oluşturmaktadır. AML morfolojik, sitokimyasal ve immünofenotipik özelliklere göre sınıflandırılabilir. AML hastaları lösemik hücrelerin tuttuğu organ ve dokulara göre çeşitli klinik bulgu ve semptomlarla başvurabilirler. Yaş, cinsiyet, ırk, hastanın yapısal özellikleri ve sitogenetik anormallikler AML’de prognozu etkileyen önemli faktörlerdir. AML tedavisinde amaç hastaya verilen en az toksisite ile tam remisyon ve bu remisyonun devamını sağlamaktır. Bu çalışmada, çocukluk çağı AML etiyoloji, sınıflama, klinik özellikler, prognoz ve tedavi stratejileri incelenmiştir

Acute Myeloid Leukemia in Childhood

Acute leukemia is basically divided into acute lymphoblastic leukemia and acute myeloid leukemia (AML). About 15-20% of childhood leukemia is caused by AML. AML is classified according to morphological, cytochemical and immunophenotypic characteristics. AML patients may present with various clinical signs and symptoms due to leukemic cell infiltration. Age, gender, race, structural features of the patient and cytogenetic abnormalities are important factors affecting prognosis in AML. The goal in the treatment of AML is to provide complete remission with the least toxicity given to the patient and to maintain this remission. In this study, etiology, classification, clinical features, prognosis and treatment strategies of childhood AML were investigated.

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