Olcay KIROĞLU, Fazilet AKSU, Fatih BERKTAŞ

Antidepresan İlaçların Öğrenme ve Bellek Mekanizmas ına Etkileri

Depresyon yaşam kalitesini ve iş gücünü olumsuz yönde etkileyen psikiyatrik bir hastalıktır. Son yıllarda affektif hastalıkların oluşumunda, yapısal plastisite ve hücre yapılarında meydana gelen patolojik değişimlerin önemli olduğu konusundaki görüşler artmıştır. Bu görüşlerin odağında hipokampal alan bulunmaktadır. Hipokampusun epizodik bellek, ifadesel bellek, içerik ve uzaysal bellekte birincil önemi vardır. Uzun dönem potansiyalizasyon olarak bilinen ve öğrenme veya bellek mekanizmalarından biri olan "nöral plastisite" ilk olarak bu yapıda saptanmış ve incelenmiştir. Bu olgunun hafıza oluşumundaki temel nöronal mekanizma olduğuna inanılmaktadır. Depresyonda strese bağlı oluşan öğrenme-bellek mekanizmalarındaki olumsuz etkilerin antidepresan tedavi ile düzeltilebileceğine dair çalışmalar bulunmaktadır. Bu yazıda antidepresan ilaçların öğrenme-bellek mekanizmaları üzerine etkilerinin araştırıldığı çalışmalar incelenmiştir

Effects of Antidepressant Drugs on Learning and Memory Mechanism

Depression is a psychiatric disease that negatively affects quality of life and workforce. In recent years there is an increase in suggestions that the formation of affective disorders were caused by pathological changes influencing structural plasticity and cell structures. These studies primarily focused on the hippocampal area. Hippocampus is especially important in regards to episodic memory, expressive memory, content and spatial memory. “Neural plasticity”, known as long term potentiation of learning and memory mechanisms, was firstly identified and examined in this structure.This phenomenon is believed to be fundamental neuronal mechanisms involved in memory formation. Antidepressant treatment can correct negative effects of learning and memory mechanisms induced by stress. This study reviews studies focusing on effects of antidepressants on learning-memory mechanisms

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ISSN: 1300-3755
Yayın Aralığı: Yılda 4 Sayı
Başlangıç: 1992
Yayıncı: Çukurova Üniversitesi Tıp Fakültesi

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