Anjali SRİNİVASAN, Prashanth SHENAİ, Laxmikanth CHATRA, Veena KM, Prasanna Kumar RAO

Ağrı Kesici Olarak Topikal İlaçlar

Topikal terapi ülser, yanan ağız sendromu, temporomandibular bozukluklar, nöromalar ve nöraljiler gibi oral ya da perioral ağrı sorunu olan hastalara yardımcı olur.Diş hekimliği alanında kullanılan topikal ilaçlar topikal anestezikler, topikal analjezikler, topikal antibiyotikler ve topikal kortikosteroidlerdir. Semptomatik ya da tedavi edici etki sağlarlar. Topikal ilaçların uygulaması kolaydır, karaciğerin ilk geçiş metabolizmasından etkilenmezler ve uygulandığı alanlara daha özgüldürler. Ancak terapötik etki gösterirken daha düşük plazma konsantrasyonu gerektiren durumlarda kullanılan ilaçlardır.

Anahtar Kelimeler:

Topikal terapi, topikal analjezikler, diş hekimliği, ilaçlar

Topical Drugs for Pain Relief

Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect.

Keywords:

Topical therapy, topical analgesics topical antibiotics, topical anesthetics, topical corticosteroids, drugs,

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Hargreaves K, Abbott PV. Drugs for pain management in dentistry. Aust Dent J. 2005;50:14-22.
Bonica JJ. The need of a taxonomy. Pain. 1979;6:247-48.
Singla V, Saini S, Joshi B, Rana AC. Emulgel: a new platform for topical drug delivery. International Journal of Pharma and Bio Sciences. 2012;3:485-98.
Moody ML. Topical medications in the treatment of pain. Pain Medicine news special edition 2010.
Bhatia J. Herbal Remedies for Natural Pain Relief. Pain management centre-Everyday health .com. http:// www.everydayhealth.com.
Adriani J, Zepernick R. Clinical effectiveness of drugs used for topical anesthesia. JAMA. 1964;188:711–16.
Bennett CR. Monheim’s Local Anesthesia and Pain Control In Dental Practice, Seventh edition. St. Louis, Mosby, 1984.
Guideline on Dental Management of Pediatric Patients Receiving Chemotherapy, Hematopoietic Cell Transplantation, and/or Radiation REFERENCE MANUAL.1994;35:284-92.
Abu Al-Melh M, Anderson L. Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:16-20.
Turhal NS, Erdal S, Karacay S. Efficacy of treatment to relieve mucositis-induced discomfort. Support Care Cancer. 2000;8:55-8.
Tripathi KD. Essentials of Medical Pharmacology, Seventh edition. New Delji, Jaypee Brothers, 2013.
Vayne-Bossert P, Escher M, de Vautibault CG, Dulguerov P, Allal A, Desmeules J et al. Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: a randomized double-blinded study. J Palliat Med. 2010;13:125-8.
Agarwal S, Mathur S, Kothiwale S, Benjamin A. Efficacy and acceptability of 0.074% diclofenac- containing mouthwash after periodontal surgery: A clinical study. Indian J Dent Res.2010;21:408- 12.
Oral salicylate gels: not for use in those younger than age 16 years. Drug Safety Update.2009;2:4.
Oman TK, Stewart MC, Burns A, Lang TF. Topical choline salicylates implicated in Reye’s syndrome. BMJ. 2008;336:1376.
Fariba I, Taghi G, Samani Mazdak E, Maryam T, Hossein SA, Shahla E et al. The efficacy of 3% diclofenac in 2.5% hyaluronan gel base for treatment of recurrent aphthous stomatitis (RAS): A double blind study. Egyptian Dermatology Online Journal. 2005;1:4.
Gorsky M, Epstei JB, Rabenstein S, Elishoov H, Yarom N. Topical minocycline and tetracycline rinses in treatment of recurrent aphthous stomatitis: a randomized cross-over study. Dermatology Online Journal. 2014;13:1.
Masthan KMK, Babu NA, Jha A, Elumalai M. Steroids application in oral diseases. International Journal of Pharma and Bio Sciences. 2013;4:829-34.
Mehdipour M, Zenouz AT. Role of Corticosteroids in Oral Lesions. In State of the Art of Therapeutic Endocrinology (Ed S Magdeldin):87-120. Croatia, InTech, 2012.
Luiz AC, Hiraki KR, Lemos CA Jr, Hirota SK, Migliari DA. Treatment of painful and recurrent oral mucoceles with a high-potency topical corticosteroid: a case report. J Oral Maxillofac Surg. 2008;66:1737-9.
Holzer P. Capsaicin: cellular targets, mechanisms of action and selectivity for thin sensory neurons. Pharmacol Rev. 1991;43:143–201.
Sunil A, Mukunda A, Gonsalves MN, Basher AB, Deepthi K. An overview of burning mouth syndrome. Indian Journal of Clinical Practice. 2012;23:145-52.
Bernstein JE, Korman NJ, Bickers DR, Dahl MV, Millikan LE. Topical capsaicin treatment of chronic postherpetic neuralgia. J Am Acad Dermatol.1989;21:265–70.
Watson CPN, Tyler KL, Rickers DR, Millikan LE, Smith S, Coleman E. A randomized vehicle- controlled trial of topical capsaicin in the treatment of post- herpetic neuralgia. ClinTher. 1993;15:510-26.
Epstein JB, Marcoe JH. Topical capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol. 1994;77:135–40.
Hersh EV, Pertes RA, Ochs HA Topical capsaicin – pharmacology and potential role in the treatment of temperomandibular pain. J Clin Dent. 1994;5:54–9.
Vickers ER, Cousins MJ, Walker S, Chisholm K. Analysis of 50 patients with atypical odontalgia. A preliminary report on pharmacological procedures for diagnosis and treatment. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 1998;85:24-32.
Dheepika B, Maheswari TNU. Aloe vera in oral diseases: A review. International Journal of Pharmacy and Pharmaceutical Sciences. 2013;6(Suppl 2):64-6.
Poor MR, Hall JE , Poor AS. Reduction in the incidence of alveolar osteitis in patients treated with SaliCept Patch, containing acemannan hydrogel. J Oral Maxillofac Surgery.2002;60:374-9.
Correspondence Address / Yazışma Adresi Prashanth Shenai
Department of Oral Medicine and Radiology
Yenepoya Dental College, Yenepoya University.
Deralakatte.Mangalore Karnataka, India.
e-mail :prashanthshenai4@gmail.com