Stabil kronik obstrüktif akciğer hastalığında ortalama trombosit hacmi ve trombosit dağılım genişliğinin hastalık şiddeti ile ilişkisinin değerlendirilmesi

Amaç: Bu çalışmada kronik obstrüktif akciğer hastalığında ortalama trombosit hacmi ve trombosit dağılım genişliği ile hastalık şiddeti arasındaki ilişkinin değerlendirilmesi amaçlandı. Yöntemler: Çalışmaya 120 ardışık kronik obstrüktif akciğer hastası ve yaşları eşleştirilmiş 30 ardışık sağlıklı kişi (kontrol grubu) alındı. GOLD komitesi tarafından tanımlanan kronik obstrüktif akciğer hastalığı şiddetini belirlemek için hastalar A (hafif), B (hafif-orta), C (orta-şiddetli) ve D (şiddetli) olarak sınıflandı ve A/B (n=60) ve C/D (n=60) olarak gruplandı.Bulgular: Gruplar arasında trombosit düzeylerinin istatistiksel olarak anlamlı olmadığı bulundu. Ortalama trombosit hacmi tüm hastalarda kontrollere göre daha düşüktü (p=0.001). Tüm hastalarda trombosit dağılım genişliği düzeyleri kontrol grubundan daha yüksekti (p=0.018). Ortalama trombosit hacmi C/D grubunda, A/B grubu (p=0.011) ve kontrol grubundan (p=0.001) anlamlı olarak düşük bulundu. Ortalama trombosit hacmi, A/B grubunda kontrol grubundan anlamlı derecede düşük bulundu (p=0.001). Eritrosit sedimantasyon hızı A/B ve C/D gruplarında kontrol grubundan daha yüksek iken (sırasıyla, p=0.007 ve p=0.001). C-reaktif protein düzeyleri kontrol grubunda C/D grubundan anlamlı derecede düşük bulundu (p=0.001). A/B veya C/D gruplarında ortalama trombosit hacmi ile bir saniyedeki zorlu ekspiratuar hacim, bir saniyedeki zorlu ekspiratuar hacim/zorlu vital kapasite oranı ve diğer inflamatuar parametreler arasında istatistiksel olarak anlamlı bir ilişki görülmedi. C/D grubunda eritrosit sedimantasyon hızı, C-reaktif protein düzeyleri (r=0.375; p=0.003) ile ve ortalama trombosit hacmi de büyük hücreli platelet oranı ile (r=0.749; p=0.001) pozitif korelasyon gösterdi. Sonuç: Bu çalışma kronik obstrüktif akciğer hastalığında klasik pozitif akut faz reaktanı C-reaktif proteinin yanı sıra düşük ortalama trombosit hacmi’nin hastalık şiddetinin değerlendirilmesinde negatif akut faz reaktanı olarak kullanılabileceğini düşündürmektedir.

Anahtar Kelimeler:

Kronik obstrüktif akciğer hastalığı, ortalama trombosit volümü, trombosit dağılım genişliği, zorlu ekspiratuar hacim, zorlu vital kapasite

Evaluation of relationship between disease severity, mean platelet volume, and platelet distribution width in stable chronic obstructive pulmonary disease

Aim: This study was conducted to evaluate the relationship between disease severity, mean platelet volume and platelet distribution width in stable chronic obstructive pulmonary disease. Methods: The study included 120 consecutive patients with stable chronic obstructive pulmonary disease and 30 consecutive age-matched healthy subjects (control group). Patients were classified as A (mild), B (mild to moderate), C (moderate to severe) and D (severe) defined by the GOLD committee and grouped as A/B (n= 60) and C/D (n=60).Results: Platelet levels were not different among the groups. Mean platelet volume was lower in all patients than control group (p=0.001). Level of platelet distribution width was higher in all patients than control group (p=0.018). Mean platelet volume in C/D groups were significantly lower than A/B group (p=0.011) and control group (p=0.001). Mean platelet volume in A/B group were also significantly lower than control group (p=0.001). Erythrocyte sedimentation rates were higher in A/B and C/D groups than control group (p=0.007 and p=0.001, respectively). C-reactive protein levels in control group were significantly lower than C/D group (p=0.001). No statistically significant correlations were observed between mean platelet volume and forced expiratory volume in one second and forced expiratory volume in one second/forced vital capacity or between mean platelet volume and other inflammatory parameters in A/B or C/D groups. Significant positive correlations were found between erythrocyte sedimentation rate and C-reactive protein (r=0.375; p=0.003), and between mean platelet volume and platelet large cell ratio (r=0.749; p=0.001) in C and D groups. Conclusion: It was concluded that mean platelet volume could be used as a negative acute‑phase reactant in evaluation of disease severity of chronic obstructive pulmonary disease as C-reactive protein.

Keywords:

Chronic obstructive pulmonary disease, mean platelet volume, platelet distribution width, forced expiratory volume, forced vital capacity,

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