FLAVONOİDLER ve BİYOLOJİK AKTİVİTELERİ

Flavonoidler; sebze, meyve, çiçek, kuruyemiş, tohum, çay, bal ve propoliste bulunan polifenolik fitokimyasallardır. İnsan ve hayvan sağlığını destekleyen ve hastalık riskini azaltmaya yardımcı olan kapsamlı biyolojik özelliklere sahiptirler bu yüzden geçmişten günümüze bu bileşikleri içeren bitkiler farklı hastalıkları tedavi etmek için kullanılmıştır. Flavonoidlerin yapısal fonksiyon ilişkisi, başlıca biyolojik aktivitelerin özetidir. Antibakteriyel, hepatoprotektif, anti inflamatuar, antikanser ve antiviral ajanlar gibi birçok flavonoidin tıbbi etkinliği iyi bilinmektedir. Bazı viral salgınlar, en son COVID-19 salgını da dahil olmak üzere yıllardır insanlığın yüzleştiği bir durum olmuştur ve bu hastalıkları iyileştirmek için bitkilerin kullanımını araştıran birçok araştırmacı, İn vitro ve in vivo çalışmalarda, flavonoidlerin birçok bulaşıcı (bakteriyel ve viral hastalıklar), kardiyovasküler hastalıklar, dejeneratif hastalıklar, kanser ve diğer yaşa bağlı hastalıklarda antitümör, kardiyovasküler hastalıkların önlenmesi, antibakteriyel antifungal, anti-alerjik, östrojenik, anti-inflamatuar ve antiviral aktiviteler gibi etkileyici biyokimyasal aktivitelere sahip olduğunu gözlemlemiştir. Bu derlemede flavonoidlerin çeşitli biyolojik aktiviteleri incelenecektir.

Anahtar Kelimeler:

FLAVONOİDLER, ANTİ-KANSER, ANTİ-VİRAL

BIOLOGİCAL ACTIVITIES OF FLAVONOIDS

Flavonoids; are polyphenolic phytochemicals found in vegetables, fruits, flowers, nuts, seeds, tea, honey and propolis. They have extensive biological properties that support human and animal health and help reduce the risk of disease, so plants containing these compounds have been used to treat different diseases from past to present. Some viral outbreaks have been a situation humanity has faced for years, including the most recent COVID-19 outbreak .Many researchers investigating the use of plants to cure these diseases, In vitro and in vivo studies, flavonoids in many infectious (bacterial and viral diseases), cardiovascular diseases, degenerative diseases, cancer and other age-related diseases, antitumor, cardiovascular disease prevention, antibacterial antifungal, anti- observed that it has impressive biochemical activities such as allergic, estrogenic, anti-inflammatory and antiviral activities. In this review, various biological activities of flavonoids will be examined.

Keywords:

FLOVONOIDS, ANTI-CANCER, ANTI-VIRAL,

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