Gamze VAROL, Dumrul GÜLEN, Hülya ALBAYRAK, Gamze ERFAN, Berna ERDAL, Mine AYDIN KURC, Mehmet Emin YANIK

The role of serum Pro- and Anti-inflammatory cytokines as potential diagnostic markers for psoriasis

Aim: Cytokines secreted by T helper cell subgroups are considered to play chief roles in the complex pathobiology of psoriasis.Herein, we aimed to reveal the effects of anti- and pro-inflammatory cytokines on the pathobiology of psoriasis disease and thecorrelation of these cytokines with severity of psoriasis.Materials and Methods: Thirty-seven individuals diagnosed with psoriasis and 37 healthy control subjects were enrolled for thestudy. The levels of Tumor necrosis factor alpha (TNFα), Soluble CD40 ligand (sCD40L), Interferon gamma (IFNγ) and Interleukin (IL)1β, IL4, IL6, IL10, IL17F, IL17A, IL21, IL22, IL23, IL25, IL31, IL33 were determined by the Luminex method.Results: The IL6, IFNγ, TNFα, sCD40L, IL17F, IL17A, IL23, IL25, and IL31 levels were found to be markedly advanced in individualswith psoriasis in contrast to the control group (p=0.003, p=0.02, p

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1. de Masson A, Bouaziz JD, Battistella M, et al. Immunopathology of psoriasis: from bench to bedside. Med Sci (Paris) 2016;32:253-9.
2. Sarac G, Koca TT, Baglan T. A brief summary of clinical types of psoriasis. North Clin Istanb 2016;3:79-82.
3. Nast A, Jacobs A, Rosumeck S, et al. Efficiacy and safety of systemic long-term treatments for moderateto-severe psoriasis: a systematic review and metaanalysis. J Invest Dermatol 2015;135:2641-8.
4. Chamian F, Krueger JG. Psoriasis vulgaris: an interplay of T lymphocytes, dendritic cells, and inflammatory cytokines in pathogenesis. Curr Opin Rheumatol 2004;16:331-7.
5. Lew W, Bowcock AM, Krueger JG. Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression. Trends Immunol 2004;25:295-305.
6. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med 2009;361:496-509.
7. Reich K, Mössner R, König IR, et al. Promoter polymorphisms of the genes encoding tumor neccrosis factor-alpha and interleukin-1 beta are associated with different subtypes of psoriasis characterized by early and late disease onset. J Invest Dermatol 2002;118:155-63.
8. Yilmaz SB, Cicek N, Coskun M, et al. Serum and tissue levels of IL-17 in different clinical subtypes of psoriasis. Arch Dermatol Res 2012;304:465-9.
9. Ma L, Xue HB, Guan XH, et al. The imbalance of Th17 cells and CD4(+) CD25(high) Foxp3(+) Treg cells in patients with atopic dermatitis. J Eur Acad Dermatol Venereol 2014;28:1079-86.
10. Brito-Luna MJ, Villanueva-Quintero DG, SandovalTalamantes AK, et al. Correlation of IL-12, IL-22, and IL-23 in patients with psoriasis and metabolic syndrome. Preliminary report. Cytokine 2016;85:130- 6.
11. Bulur I, Gulekon A, Erdem O, et al. The interaction of osteopontin and related cytokin levels with disease activity, treatment and comorbidities in psoriasis vulgaris. Türkderm 2013;47:142-7.
12. Sabat R, Philipp S, Höflich C, et al. Immunopathogenesis of psoriasis. Exp Dermatol 2007;16:779-98.
13. Lowes MA, Kikuchi T, Fuentes-Duculan J, et al. Psöriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 2008;128:1207- 11.
14. Bonifati C, Carducci M, Mussi A, et al. IL-1 alpha, IL-1 beta and psoriasis: conflicting results in the literatüre. Opposite behaviour of the two cytokines in lesional or non-lesional extracts of whole skin. J Biol Regul Homeost Agents 1997;11:133-6.
15. Bai F, Zheng W, Dong Y, et al. Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis. Oncotarget 2017;9:1266- 78.
16. Erturan I, Koroglu BK, Adiloglu A, et al. Evaluation of serum sCD40L and homocysteine levels with subclinical atherosclerosis indicators in patients with psoriasis: a pilot study. Int J Dermatol 2014;53:503-9.
17. Verghese B, Bhatnagar S, Tanwar R, et al. Serum cytokine profile in psoriasis-a case-control study in a tertiary care hospital from northern India. Indian J Clin Biochem 2011;26:373-7.
18. Borska L, Andrys C, Krejsek J, et al. Serum levels of the pro-inflammatory cytokine interleukin-12 and the anti-inflammatory cytokine interleukin-10 in patients with psoriasis treated by the Goeckerman regimen. Int J Dermatol 2008;47:800-5.
19. Arican O, Aral M, Sasmaz S, et al. Serum levels of TNFalpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm 2005;5:273-9.
20. Senra L, Stalder R, Alvarez Martinez D, et al. Keratinocyte-derived IL-17E contributes to inflammation in psoriasis. J Invest Dermatol 2016;136:1970-80.
21. Narbutt J, Olejniczak I, Sobolewska-Sztychny D, et al. Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients. Arch Dermatol Res 2013;305:191-5.
22. Mitsui A, Tada Y, Takahashi T, et al. Serum IL-33 levels are increased in patients with psoriasis. Clin Exp Dermatol 2016;41:183-9.