The role of plateletcrit and neutrophil lymphocyte ratio in showing the clinical severity of the disease in patients with chronic venous insufficiency

The role of plateletcrit and neutrophil lymphocyte ratio in showing the clinical severity of the disease in patients with chronic venous insufficiency

Aim: Chronic venous insufficiency (CVI) is a common disease and affects approximately 40% of the population. In this study, weaimed to investigate the relationship of neutrophil to lymphocyte ratio (NLR) and plateletcrit (PCT) values with the clinical severity ofthe disease in patients diagnosed with CVI.Material and Methods: The patients hospitalized to our clinic for treatment with the diagnosis of chronic venous insufficiencybetween August 2014 and August 2019 were included in the study retrospectively. Patients were divided into two groups as Group1 including patients with stage C1, C2, C3 disease and Group 2 including patients with stage C4, C5, C6 disease according to theclinical evaluation in CEAP staging.Results: There were 119 patients in Group 1 and their median age was 35 (18- 66) years. There were 55 patients in Group 2 andtheir median age was 44 (19- 65) years. In multivariate logistic regression analysis, the presence of concomitant perforator veinincompetence (Odds ratio(OR): 1.527, CI 95%: 1.481-2.846 p = 0.019), presence of concomitant deep venous insufficiency (OR: 1.978CI 95%: 1.250-2.979 p = 0.020), NLR (OR: 3.244, CI 95%: 1.384-4.825 p

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  • 1. Durmaz MS, Ozbakir B, Cebeci H, et al. The cutoff value for the diameter of the saphenous vein in predicting the presence of venous insufficiency. Ann Med Res 2018;25:135-9.
  • 2. Rabe E, Pannier F. Clinical, aetiological, anatomical and pathological classification (CEAP): gold standard and limits. Phlebology 2012;27:114-8.
  • 3. Akbulut B, Tok M, Ucar HI, et al. Common venous system disorders: prevalence, risk factors, and management. Anatol J Clin Investig 2009:3:113-9.
  • 4. Sarica MA, Kızıldag B, Selcuk MY, et al. Mean Platelet Volume in Patients with Chronic Venous Insufficiency. J Clin Exp Invest 2016;7:73-7.
  • 5. Mosmiller LT, Steele KN, Shrader CD, et al. Evaluation of inflammatory cell biomarkers in chronic venous insufficiency. Phlebology 2017;32:634-40.
  • 6. Budak AB, Gunertem OE, Tumer NB, et al. Prognostic value of neutrophil-to-lymphocyte ratio in patients undergoing endovenous ablation therapy for venous insufficiency. Turk J Vasc Surg 2017;26:98-103.
  • 7. Lu X, Chen Y, Huang Y, et al. Venous hypertension induces increased platelet reactivity and accumulation in patients with chronic venous insufficiency. Angiology 2006;57:321-9.
  • 8. Cetin MS, Ozcan Cetin EH, Akdi A, et al. Platelet distribution width and plateletcrit: novel biomarkers of ST elevation myocardial infarction in young patients. Kardiol Pol 2017;75:1005-12.
  • 9. Akpinar I, Sayin MR, Gursoy YC, et al. Plateletcrit and red cell distribution width are independent predictors of the slow coronary flow phenomenon. J Cardiol 2014;63:112-8.
  • 10. Konoeda H, Yamaki T, Hamahata A, et al. Quantification of superficial venous reflux by duplex ultrasoundrole of reflux velocity in the assessment the clinical stage of chronic venous insufficiency. Ann Vasc Dis 2014;7:376-82.
  • 11. Akca B, Erdil N, Colak MC, et al. Kronik venöz yetersizliğin aynı seansta büyük safen ven endovenöz radyofrekans ablasyon ve miniflebektomi ile tedavisi. Turk J Vasc Surg 2017;26:85-90.
  • 12. Bergan JJ, Schmid-Schönbein GW, Smith PD, et al. Chronic venous disease. N Engl J Med 2006; 355:488- 98.
  • 13. Comerota AJ, Ramelet AA, Jawien A, et al. Treatment of chronic venous disease of the lower extremities: what’s new in guidelines? Phlebolymphology 2009;16:313-20.
  • 14. Eberhardt RT and Raffetto JD. Chronic venous insufficiency. Circulation 2014;130:333-46.
  • 15. Lee AJ, Robertson LA, Boghossian SM, et al. Progression of varicose veins and chronic venous insufficiency in the general population in the Edinburgh Vein Study. J Vasc Surg Venous Lymphat Disord 2015; 3:18-26.
  • 16. Raffetto JD and Mannello F. Pathophysiology of chronic venous disease. Int Angiol 2014; 33:212-21.
  • 17. Smith PDC, Thomas P, Scurr JH, et al. Causes of venous ulceration: A new hypothesis. Br Med J 1988; 296:1726-7.
  • 18. Li N, Hu H, Lindqrist M, et al. Platelet-leukocyte cross talk in whole blood. Arterioscler Thromb Vasc Biol 2000; 20:2702-8.
  • 19. Karahan O, Yavuz C, Kankilic N, et al. Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency. Blood Coagul Fibrinolysis 2016;27:684-90.
  • 20. Smith RK, Quigley F, Tosenovsky P, et al. Serum homocysteine is associated with the severity of primary chronic venous disease. Phlebology 2016; 31:409-15.
  • 21. Dudman N, Temple SE, Guo XW, et al. Homocysteine enhances neutrophil-endothelial interactions in both cultured human cells and rats In vivo. Circ Res 1999; 84:409-16.
  • 22. Barry OP, Pratico D, Savani RC, et al. Modulation of monocyte-endothelial cell interactions by platelet microparticles. J Clin Invest 1998;102:136-44.
  • 23. Braekkan SK, Mathiesen EB, Njølstad I, et al. Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø Study, Tromsø, Norway. J Thromb Haemost 2010;8:157-62.
  • 24. Gloviczki P, Rhodes Jm. Management Of Perforating Vein İncompetence. In: Rutherford Rb, Editor. Rutherford’s Textbook On Vascular Surgery. 5th Ed. Philadelphia: WB Saunders 2000;2021-36.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
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