The relation between monocyte/HDL-cholesterol ratio and dipper/non-dipper blood pressure status in patients with newly diagnosed hypertension

AbstractAim: In this study, It was ivestigated to see if there was a correlation between dipper and non-dipper hypertension conditions and the MHR in patients newly diagnosed with hypertension.Material and Methods: One hundred and thirty-nine newly diagnosed hypertension patients who admitted department of cardiology. Patients were divided into two groups; dipper group and non-dipper group and Monocyte/HDL-cholesterol Ratio, high sensitive-C reactive protein and dipper/non-dipper status were examined.Results: There were 61 patients (mean age 47±13 and 48% male) in the dipper group and 78 patients (mean age 52±12and 49% male) in the non-dipper group. Mean MHR was 0.01550±0.00447 in dipper group and 0.01810±0.00661 in non-dipper group. Mean MHR was significantly higher in non-dipper group (0.009). There was a significant and positive correlation between MHR and Hs-CRP(r=0.350; p

PDF

___

1. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ ESH Guidelines for the management of arterial hypertension. Eur Heart J 2018;39:3021-104.
2. Verdecchia P, Schillaci G, Guerrieri M, et al. Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension. Circulation 1990;81:528-36.
3. Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension 1994;24:793- 801.
4. Aukrust P, Halvorsen B, Yndestad A, et al. Chemokines and cardiovascular risk. Arterioscler Thromb Vasc Biol 2008;28:1909-19.
5. Guzik TJ, Touyz RM. Oxidative Stress, Inflammation, and Vascular Aging in Hypertension. Hypertension 2017;70:660-7.
6. Kundi H, Kiziltunc E, Cetin M, et al. Association of monocyte/HDL-C ratio with SYNTAX scores in patients with stable coronary artery disease. Herz 2016;41:523-9
7. Ganjali S, Gotto AM Jr, Ruscica M, et al. Monocyteto-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases. J Cell Physiol 2018;233:9237-46.
8. Aydin E, Ates I, Fettah Arikan M, et al. The ratio of monocyte frequency to HDL cholesterol level as a predictor of asymptomatic organ damage in patients with primary hypertension. Hypertens Res 2017;40:758-64.
9. Sag S, Yildiz A, Aydin Kaderli A, et al. Association of monocyte to HDL cholesterol level with contrast induced nephropathy in STEMI patients treated with primary PCI. Clin Chem Lab Med 2017;55:132-8.
10. Cetin MS, Ozcan Cetin EH, Kalender E, et al. Monocyte to HDL Cholesterol Ratio Predicts Coronary Artery Disease Severity and Future Major Cardiovascular Adverse Events in Acute Coronary Syndrome. Heart Lung Circ 2016;25:1077-86.
11. Poulter NR, Prabhakaran D, Caulfield M. Hypertension. Lancet 2015;386:801-12.
12. Cuspidi C, Michev I, Meani S, et al. Non-dipper treated hypertensive patients do not have increased cardiac structural alterations. Cardiovasc Ultrasound 2003;1:1.
13. Birkenhäger AM, van den Meiracker AH. Causes and consequences of a non-dipping blood pressure profile. Neth J Med 2007;65:127-31.
14. Ohkubo T, Imai Y, Tsuji I, et al. Relation between nocturnal decline in blood pressure and mortality. The Ohasama Study. Am J Hypertens 1997;10:1201-7.
15. Seo WS, Oh HS. The circadian rhythms of blood pressure and heart rate in the hypertensive subjects: dippers and non-dippers. Yonsei Med J 2002;43:320- 8.
16. Tosu AR, Demir S, Selcuk M, et al. Comparison of inflammatory markers in non-dipper hypertension vs. Dipper hypertension and in normotensive individuals: uric acid, C-reactive protein and red blood cell distribution width readings. Postepy Kardiol Interwencyjnej 2014;10:98-103.
17. Kaya MG, Yarlioglues M, Gunebakmaz O, et al. Platelet activation and inflammatory esponse in patients with non-dipper hypertension. Atherosclerosis 2010;209:278-82.
18. Gunebakmaz O, Kaya MG, Duran M, et al. Red blood cell distribution width in ‘non-dippers’ versus ‘dippers’. Cardiology 2012;123:154-9.
19. Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science 2013;339:161-6.
20. Gratchev A, Sobenin I, Orekhov A, et al. Monocytes as a diagnostic marker of cardiovascular diseases. Immunobiology 2012;217:476-82.
21. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868-74.
22. Li XP, Zhao SP, Zhang XY, et al. Protective effect of high density lipoprotein on endothelium-dependent vasodilatation. Int J Cardiol 2000;73:231-6.
23. Gunes H, Duksal F, Parlak M. Can monocyte to HDL ratio be used as an inflammatory marker in children with familial mediterranean fever? Annals of Med Research 2019;26:1453-7.
24. Tuncez A. Comparative effects of atorvastatin 80 mg versus rosuvastatin 40 mg on the neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and monocyte to HDL-cholesterol ratio in patients with acute myocardial infarction. Annals of Med Research 2019;26:2045-52.
25. Kucuk B, Sirakaya E, Duru Z, et al. Monocyte / highdensity lipoprotein ratio and neutrophil-to-lymphocyte ratio in age-related macular degeneration. Annals of Med Research 2019;26:1880-4.
26. Akboga MK, Balci KG, Maden O, et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark Med 2016;10:375-83.
27. Sercelik A, Besnili AF. Increased monocyte to highdensity lipoprotein cholesterol ratio is associated with TIMI risk score in patients with ST-segment elevation myocardial infarction. Rev Port Cardiol 2018;37:217- 23.
28. Wang HY, Shi WR, Yi X, et al. Assessing the performance of monocyte to high-density lipoprotein ratio for predicting ischemic stroke: insights from a population-based Chinese cohort. Lipids Health Dis 2019;18:127.
29. Meric M, Yuksel S, Coksevim M, et al. The Effect of Mean Platelet Volume/Platelet Count Ratio on Dipper and Non-Dipper Blood Pressure Status. Medicina (Kaunas). 2019;55.
30. Buyukkaya E, Erayman A, Karakas E, et al. Relation of red cell distribution width with dipper and non-dipper hypertension. Med Glas (Zenica) 2016;13:75-81.
31. Ahbap E, Sakaci T, Kara E et al. Serum uric acid levels and inflammatory markers with respect to dipping status: A retrospective analysis of hypertensive patients with or without chronic kidney disease. Clin Exp Hypertens 2016;38:555-63.
32. Kim KI, Lee JH, Chang HJ, et al. Association between blood pressure variability and inflammatory marker in hypertensive patients. Circ J 2008;72:293-8.