The effect of isotretinoin on depression and anxiety in patients with acne vulgaris: A prospective study
The effect of isotretinoin on depression and anxiety in patients with acne vulgaris: A prospective study
Aim: The aim of this study was to evaluate the effect of isotretinoin on depression and anxiety.Material and Methods: Beck depression and Beck anxiety scales were performed by the clinician before the initiation of isotretinointherapy. At follow-up, 0.5 mg/kg/day isotretinoin was administered to the patients. In the third month of the treatment, 39 patientswere reevaluated with the same scales.Results: There was no statistically significant difference in pre-treatment (11.38±12.48) vs. post-treatment (10.48±9.77) changein Beck anxiety scale points. Similarly, although there was a decrease in the Beck depression scale scores in the pre-treatment(10.05±9.02) and post-treatment (8.74±9.45) scores, no significant difference was found. Although the decrease in scores wasnot statistically significant, the decrease in both depression and anxiety scores after treatment showed a statistically significantcorrelation in itself (p
___
- 1. Elibüyük SA, Bilgili S, Yavuz İ, et al. Akne Vulgariste
Etyopatogenez Etiopathogenesis of Acne Vulgaris. Van Tıp
Derg 2018;25:260-7.
- 2. Bondade S, Hosthota A, Basavaraju V. Stressful life events
and psychiatric comorbidity in acne-a case control study.
Asia Pac Psychiatry 2019;11:e12340.
- 3. Layton A. The use of isotretinoin in acne. Dermatoendocrinol
2009;1:162-9.
- 4. İslamoğlu ZGK, Altınyazar HC. Effects of isotretinoin on the
hair cycle. J Cosmet Dermatol 2019;18:647-51.
- 5. Rea S, Tucker S, Frittelli V, A feasibility study for a triple-blind
randomized controlled trial investigating the effects of oral
isotretinoin on mood and quality of life in patients with acne
vulgaris. Clin Exp Dermatol 2018;43:54-6.
- 6. Ozturk M, An I. A case of flat wart that responds perfectly to
isotretinoin. Ann Med Res 2019;26:125-6
- 7. Kırkağaç A, Saraçoğlu ZN, Aksu AEK. Comparison of the
efficacy and safety of topical clindamycin and 5% benzoyl
peroxide with nadifloxacin cream and 5% benzoyl peroxide
gel in the treatment of acne vulgaris and assessment of
the effects of these treatments on quality of life. Turkderm
2015;49:54-9.
- 8. Özyay Eroğlu F, Aktepe E, Erturan İ. The evaluation of
psychiatric comorbidity, self-injurious behavior, suicide
probability, and other associated psychiatric factors
(lonileness, self-esteem, life satisfaction) in adolescents
with acne: A clinical pilot study. J Cosmet Dermatol
2019;18:916-21.
- 9. Suuberg A. Psychiatric and Developmental Effects of
Isotretinoin (Retinoid) Treatment for Acne Vulgaris. Curr
Ther Res Clin Exp 2019;90:27-31.
- 10. Bray AP, Kravvas G, Skevington SM, et al. Is there an
association between isotretinoin therapy and adverse mood
changes? A prospective study in a cohort of acne patients. J
Dermatolog Treat 2019;18:1-6.
- 11. Daunton A, Oyebode F, Goulding JMR. Depression and
the dermatologist: a critical analysis of contemporary
isotretinoin prescribing practices. Clin Exp Dermatol
2019;26.
- 12. Sule Afsar F, Seremet S, Demirlendi Duran H, et al. Elif
Yildirim F, Mumcu Sönmez N. Social Appearance Anxiety
in Adult Patients with Acne: A Cross-Sectional Study. Acta
Dermatovenerol Croat 2018;26:220-5.
- 13. Lukaviciute L, Navickas P, Navickas A, et al. Quality of
life, anxiety prevalence, depression symptomatology and
suicidal ideation among acne patients in Lithuania. J Eur
Acad Dermatol Venereol 2017;31:1900-6.
- 14. Kellett SC, Gawkrodger DJ. The psychological and emotional
impact of acne and the effect of treatment with isotretinoin.
Br J Dermatol 1999;140:273-82.
- 15. Gnanaraj P, Karthikeyan S, Narasimhan M, et al. Decrease
in “Hamilton Rating Scale for Depression” Following
Isotretinoin Therapy in Acne: An Open-Label Prospective
Study. Indian J Dermatol 2015;60:461-4.
- 16. Hatice Nur Azaklı, Emine Derviş, İlknur Altunay, ve ark. Akne
Vulgarisli Hastalarda İzotretinoin Kullanımının Anksiyete ve
Depresyon Skorlarına Etkisi. Turkderm. 2012;46:29-32
- 17. Bektemur G, Arıca S, Gençer MZ. How Should Referral Chain
be Implemented in Family Medicine in Turkey? Ankara Med
J 2018;256-66.
- 18. Bergler-Czop B, Brzezińska-Wcisło L. The new therapy
schema of the various kinds of acne based on the mucosaskin
side effects of the retinoids. Cutan Ocul Toxicol
2012;31:188-94.