Seasonal variation of pulmonary thromboembolism in Malatya, Turkey
Seasonal variation of pulmonary thromboembolism in Malatya, Turkey
Aim: Pulmonary thromboembolism (PTE) is a cause of high mortality and morbidity. The incidence of PTE increases over times. In the current study, we aimed to investigate the seasonal variation of PTE patients in Malatya, Turkey by using meteorological data. Materials and Methods: Total of 207 PTE patients were included in the study. All meteorological data; atmospheric pressure, humidity, temperature changes and wind speed were recorded. Results: In the current study, 113 (54.5%) patients were female and 94 (45.5%) patients were male. We diagnosed PTE most often in the autumn season. When the monthly distribution of patients was examined; the diagnosis was made most frequently (11.6%) in July and the least in February (4.3%). There was no statistically significant difference between the seasons and months in terms of the incidence of PTE (p > 0.5). The seasons pressure, temperature and humidity values were compared with each other, statistically significant difference was found (p = 0.00). There was a negative correlation between temperature and pressure and humidity. The frequency of PTE in patients without risk factors for PTE was examined by months. In these groups, PTE was most frequently diagnosed in May (11% n: 10) and least frequently diagnosed in July (2%, n: 3). There was no statistically significant difference between the seasons and months in terms of the incidence of patients with no risk factor for PTE (p > 0.5).
___
- 1. Ekim N. Akciğerin tromboembolik ve trombotik hastalıkları. In: Fraser RS, Colman N, Müller NL; eds. Türktaş H. Synopsis of Disease of The Chest. 3.baskı. Ankara. Güneş Kitabevi.2006. s:542-80
- 2. Stein PD, Fowler SE, Goodman LR, et al. Multi- detector computed tomography for acute pulmonary embolism. N Engl J Med 2006;354:2317-27.
- 3. Boulay F, Berthier F, Schoukroun G, et al. Seasonal varional in hospital admission for deep vein thrombosis and pulmonary tromboembolism: Analysis of discharge data. BMJ2001;323:601- 2.
- 4. Gallerani M, Boari B, Smolensky MH, et al. Seasonal variation in occurrence of pulmonary tromboembolism: analysis of the database of the Emilia-Romagna region, Italy. Chronobiol Int 2007; 24: 143-60.
- 5. Stout R, Crawford V. Seasonal variations in fibrinogen concentrations among elderly people. Lancet. 1991;338:9–13.
- 6. Sharma GV, Frisbie JH, Tow DE, et al. Circadian and circannual rhythm of nonfatal pulmonary tromboembolism. Am J Cardiol2001;87(7):922-4.
- 7. Bilora F, Boccioletti V, Manfredini R, et al. Seasonal variation in the incidence of deep vein thrombosis in patients with deficiency of protein C or protein S. Clin Appl Thromb Hemost 2002;8:231.
- 8. Stout RW, Crawford V. Seasonal variations in fibrinogen concentrations among elderly people. Lancet 1991:338
- 9. Ribeiro DD, Bucciarelli P, Braekkan SK, et al. Seasonal variation of venous thrombosis: a consecutive case series within studies from Leiden, Milan and Tromsø. J Thromb Haemost 2012; 10: 1704–7
- 10. Christensen AL, Dethlefsen C, Severinsen MT, Kristensen SR. Seasonal variation of venous thrombosis: a consecutive case series within studies from Leiden, Milan and Tromsø: a rebuttal.J Thromb Haemost. 2013;11(3):568-70.
- 11. Stein PD, Kayali F, Olson RE. Analysis of occurrence of venous thrombotromboembolic disease in the four seasons. Am J Cardiol 2004;93(4):511-3.
- 12. Bilora F, Manfredini R, Petrobelli F, et al.. Chronobiology of non-fatal pulmonary thrombotromboembolism. Panminerva Med 2001;43(1):7-10
- 13. Scott JA, Palmer EL, Fischman AJ, Strauss HW. Meteorologic influences on the frequency of pulmonary tromboembolism. Invest Radiol 1992;27(8):583-6
- 14. Lee, J. S., Moon, T., Kim, et al. Deep Vein Thrombosis in Patients with Pulmonary Embolism: Prevalance, Clinical Significance and Outcome. Vasc Specialist Int 2016, 32(4), 166-74.
- 15. Ouriel K., Green RM., Greenberg RK. The anatomy of deep venous thrombosisof the lower extremity. J Vasc Surg 2000;31:895- 900.
- 16. Simonneau G, Torbicki A, Dorfmüller P, et al. The pathophysiology of chronic thromboembolic pulmonary hypertension. Eur Respir Rev 2017; 26(143): 160112