Relationship between prostate cancer and atypical small acinar proliferation

Relationship between prostate cancer and atypical small acinar proliferation

Aim: To investigate the prostatic adenocarcinoma (PA) detection rate in follow up biopsies with an initial diagnosis of atypical smallacinar proliferation (ASAP).Materials and Methods: In this study, the cases of ASAP diagnosis in prostate needle biopsy materials between January 2010and December 2016 were retrospectively analyzed and the correlation between the results and the follow-up diagnoses of ASAPdiagnosedcases was investigated.Results: 62 cases with ASAP were included in the study and 21 (34%) of them were detected as PA after the follow-up diagnoses.Also ASAP and PA were detected at different localizations in 38% of the cases.Conclusion: We are on the opinion that it is important to increase the number of samples taken from other localizations as well asASAP diagnosed quadrants when taking follow-up biopsies.

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  • 1. Prostate Cancer Estimated Incidence, Mortality and Prevalence Worldwide in 2012 (Internet web page). http:// gco.iarc.fr/today/data/factsheets/cancers/27-Prostatefact- sheet.pdf.
  • 2. Iczkowski KA, Bassler TJ, Schwob VS, et al. Diagnosis of “suspicious for malignancy” in prostate biopsies: predictive value for cancer. Urology 1998;51:749-8.
  • 3. Bostwick DG, Srigley J, Grignon D, et. al. Atypical adenomatous hyperplasia of the prostate: morphologic criteria for its distinction from well-differentiated carcinoma. Hum Pathol 1993;24:819-32.
  • 4. Mancuso PA, Chabert C, Chin P, et al. Prostatecancer detection in men with an initial diagnosis of atypical small acinarproliferation. BJU Int 2007;99:49-52.
  • 5. Iczkowski KA, Bostwick DG. Criteria for biopsy diagnosis of minimal volumprostatic adenocarcinoma: analytic comparison with nondiagnostic but suspicious atypical small acinar proliferation. Arch Pathol Lab Med 2000;124:98-107.
  • 6. Koca O, Calışkan S, Oztürk Mİ, et al. Significance of atypical small acinar proliferation and high-grade prostatic intraepithelial neoplasia in prostate biopsy. Korean J Urol 2011;52:736-40.
  • 7. Saul Suster, Demos. Surgical Pathology Guides. Debra L. Zynger and Anil V. Parwani. In: Prostate Pathology: Premalignant Conditions and Prostate Carcinoma. New York: Bang Printing; 2015. pp. 67-162.
  • 8. Borboroglu PG, Comer SW, Riffenburgh RH, et al. Extensive repeat transrectal ultrasound guided prostate biopsy in patients with previous benign sextant biopsies. J Urol 2000;163:158-62.
  • 9. Iczkowski KA, MacLennan GT, Bostwick DG. Atypical small acinar proliferation suspicious for malignancy in prostate needle biopsies: clinical significance in 33 cases. Am J Surg Pathol 1997;21:1489-95.
  • 10. Ericson KJ, Wenger HC, Rosen AM, et al. Prostate cancer detection following diagnosis of atypical small acinar proliferation. Can J Urol 2017;24:8714-20.
  • 11. Mistry K, Cable G. Meta-analysis of prostate-specific antigen and digital rectal examination as screening tests for prostate carcinoma. J Am Board Fam Pract 2003;16:95-101.
  • 12. Törnblom M, Norming U, Adolfsson J, et al. Diagnostic value of percent free prostate-specific antigen: retrospective analysis of a population-based screening study with emphasis on men with PSA levels less than 3.0 ng/mL. Urology 1999;53:945-50.
  • 13. Lodding P, Aus G, Bergdahl S, et al. Characteristics of screening detected prostate cancer in men 50 to 66 years old with 3 to 4 ng. /ml. Prostate specific antigen. J Urol 1998;159:899-903.
  • 14. Park S, Shinohara K, Grossfeld GD, et al. Prostate cancer detection in men with prior high grade prostatic intraepithelial neoplasia or atypical prostate biopsy. J Urol 2001;165:1409-14.
  • 15. Scattoni V, Roscigno M, Freschi M, et al. Predictors of prostate cancer after initial diagnosis of atypical small acinar proliferation at 10 to 12 core biopsies. Urology 2005;66:1043-7.
  • 16. Chan TY, Epstein JI. Follow-up of atypical prostate needle biopsies suspicious for cancer. Urology 1999;53:351-5.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
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