Nesrin DİLBAZ, Hasan KAYA, Aybeniz CİVAN KAHVE, Özlem BOLAT KAYA

Evaluation of the relationship between MAOA-uVNTR gene polymorphism and impulsivity, anger, temperament and personality traits in healthy male subjects

Aim: Serotonergic activity in the central nervous system negatively correlates with personality traits associated with aggression,impulsivity and anger. MAOA is involved in the catabolism of serotonin and norepinephrine, so the gene encoding MAOA is a candidategene for aggression-related behavior. It is thought that MAOA genetic variants affect the MAOA activity at different degrees, leadingto behavioral changes as a result of a decrease in enzyme activity. The aim of this study is investigating the possible relationshipbetween the MAOA-uVNTR polymorphism genotypes and aggression, anger, impulsivity, temperament-character traits in healthymale subjects.Materials and Methods: 101 Turkish healthy male subjects were included in the study. The participants were given scales to evaluateimpulsivity, temperament and character traits, anger and aggression levels. MAOA-uVNTR polymorphism was examined with asample taken from peripheral blood.Results: A total of 101 people, 33.6% had low-activity allele and 66.4% had high-activity allele of MAOA gene. There was no significantrelationship between the temperament-character traits of the participants and MAOA-uVNTR polymorphism. Impulsivity scaleswere higher in the low-activity allele group, which was statistically significant in terms of motor impulsivity (p = 0.007), non-planningimpulsivity (p = 0.031) and total scores (p = 0.029).Conclusion: The low-activity allele of MAOA gene may be a marker for impulsivity. This requires both repetitive studies with healthycontrols in the Turkish population and studies in different cultures.

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