Ayca Serap ERDEN, Atilla BULUR, Nevsun İNANC

Evaluation of relationship between cytokine and chemokine levels measured by using multiplex laboratory method before and after treatment and clinical course and treatment response in rheumathoid arthritis patients receiving TNF-α blocker therapy

Aim: The laboratory findings are non-specific in Rheumatoid arthritis (RA). We have based our study on this idea and chose cytokinesand chemokine to evaluate ; we then tried to establish a relationship between the progress of the disease and the levels of thesemolecules before and 3-6 months after the TNF-α blocker treatment.Material and Methods: A total of 34 RA patients (28 females, 6 males) who were diagnosed with RA and received TNF-α blockertherapy were included in the study.Blood samples were drawn from the patients before the TNF-α treatment began and then in thefollowing 3rd and 6th months of the treatment.Results: The mean age of the study group is 49.15±11.03. the mean disease period is 9.77±6.29 years and the mean treatment periodis 6.88±4.33 years. 84.6% (n=22) of the study group is female and 15.4% (n=4) is male.Patients with good treatment response toTNF-α blocker treatment were younger than the patients with medium treatment response. The increase of mean hemoglobin (Hgb)levels between 0 and 6 months were statistically meaningful (both p

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