Muharrem UCAR, Mukadder SANLI

Comparison of the effects of adding fentanyl or remifentanil to propofol in colonoscopy sedoanalgesia on visual analog scale and recovery: A prospective double-blind study

Aim: In this study; our aim is to compare the effects of fentanyl or remifentanil combinations added to propofol in sedoanalgesia of colonoscopy on the visual analog scoring (VAS) and recovery of the patient.Material and Methods: Seventy patients aged between 18 and 65 who had colonoscopy were included in the study. 1 mg/kg propofol and 1 mcg/kg fentanyl, and 1 mg/kg propofol and 1 mcg/kg remifentanil were given as bolus to Group PF and Group PR, respectively. The respiratory and hemodynamic data during the procedure, and additionally pain and recovery criteria evaluated by VAS and Observer’s Assessment of Alertness/Sedation Scale (OAA / S) scores were compared at the end of the procedure.Results: There was a significant difference between the groups at 5th, 15th and 30th minutes in terms of VAS scores (p

PDF

___

1. Ahmadi A, Amri P, Shokri J, et al. Comparison of the analgesic effect of intravenous paracetamol/midazolam and fentanyl in preparation of patients for colonoscopy: A double blind randomized clinical trial. Caspian J Intern Med 2015;6:87-92.
2. Nishizawa T, Suzuki H, Hosoe N, et al. Dexmedetomidine vs propofol for gastrointestinal endoscopy: A meta-analysis. United European Gastroenterol J 2017;5:1037-45.
3. Neves JF, Araújo MM, Araújo Fde P, et al. Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam. Rev Bras Anestesiol 2016;66:231-6.
4. Bürkle H, Dunbar S, Van Aken H. Remifentanil: a novel, short-acting, ì-opioid. Anesth Analg 1996;83:646-51.
5. Doğanay G, Ekmekçi P, Kazbek BK, et al. Effects of alfentanil or fentanyl added to propofol for sedation in colonoscopy on cognitive functions: Randomized controlled trial. Turk J Gastroenterol 2017;28:453-9.
6. Stermer E, Gaitini L, Yudashkin M, et al. Patient-controlled analgesia for conscious sedation during colonoscopy: a randomized controlled study. Gastrointest Endosc 2000;51:278-81.
7. İnce İE. Çocuk Hastalarda Kısa Hematolojik-Onkolojik Girişimlerde Sedasyon: Propofol-Remifentanil, Propofol-Fentanil Karşılaştırılması. Dokuz Eylül Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı. Uzmanlık Tezi, Izmir: 2010.
8. Gras S, Servin F, Bedairia E, et al. The effect of preoperative heart rate and anxiety on the propofol dose required for loss of consciousness. Anesth Analg 2010;110:89-93.
9. Hsu CD, Huang JM, Chuang YP, et al. Propofol target-controlled infusion for sedated gastrointestinal endoscopy: A comparison of propofol alone versus propofol-fentanyl-midazolam. Kaohsiung J Med Sci 2015;31:580-4.
10. Forster C, Vanhaudenhuyse A, Gast P, et al. Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study. Br J Anaesth 2018;12:1059-64.
11. Rudner R, Jalowiecki P, Kawecki P, et al. Conscious analgesia/sedation with remifentanil and propofol versus total intravenous anesthesia with fentanyl, midazolam, and propofol for outpatient colonoscopy. Gastrointest Endosc 2003;57:657-63.
12. Wang F, Shen SR, Xiao DH, et al. Sedation, analgesia, and cardiorespiratory function in colonoscopy using midazolam combined with fentanyl or propofol. Int J Colorectal Disease 2011;26:703-8.
13. Khajavi M, Emami A, Etezadi F, et al. Conscious Sedation and Analgesia in Colonoscopy: Ketamine/Propofol Combination has Superior Patient Satisfaction Versus Fentanyl/Propofol. Anesth Pain Med 2013;3:208-13.
14. Turk HS, Aydoğmuş M, Unsal O, et al. Sedation-Analgesia in Elective Colonoscopy: Propofol-Fentanyl versus Propofol-Alfentanil. Bras J Anestesiol 2013;63:352-7.
15. Rosow C. Remifentanil: a unique opioids analgesic. Anesthesiology 1993;79:875-6.
16. Fanti L, Agostoni M, Gemma M, et al. Two dosages of remifentanil for patient-controlled analgesia vs. meperidine during colonoscopy: A prospective randomized controlled trial. Dig Liver Dis. 2013;45:310-5.
17. Arici G, Kayacan N, Dincer D, et al. Remifentanil/midazolam versus tramadol/midazolam use for colonoscopy. Hepatogastroenterology 2003;50.
18. Goulson DT, Fragneto RY. Anesthesia for gastrointesti-nal endoscopic procedures. Anesthesiol Clin 2009;27:71-85.