Selver ÖZEKİNCİ, Vahide BAZ, Selma SENGİZ ERHAN, Gülçin HARMAN KAMALI

Inter-observer compliance in the SurePath liquid-based cervicovaginal smears diagnosed with epithelial cell abnormality

Aim: To assess compliance among observers in the investigation of the liquid-based cervicovaginal smears that were reported epithelial cell abnormality in the Okmeydanı ERH Pathology laboratory.Material and Methods: 5,250 SurePath liquid-based cervicovaginal smears, which were sent by the pathology laboratory during the period of 5 months, were scanned. One-hundred and twenty-seven smears diagnosed with the epithelial cell abnormality were included in the study, and were reexamined by three pathologists. The Bethesda2001 system was used for evaluation. One of the experts had more experience in SurePath liquid-based cytology than the experience of the others.Results: There were significant differences between the three physicians because of the Friedman test (p = 0.000) that was applied for the comparison of the reports in 127 smears examined by three experienced experts in SurePath liquid-based cytology. In binary comparison with the Wilcoxon test that was applied to find out the differences among expert pathologists, there was no significant difference between the reports of the two expert pathologists (p = 0.366); however, it was found that there was a significant difference between the pathologist who had more experience and other specialist pathologists (p = 0.000).Conclusion: Moderate compliance was determined between pathologists 1 and 2, and low-level compliance was determined between pathologists 1-2 and 3.

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1. Akyüz A, Güvenç G, Yavan T. ve ark. Kadınların Pap smear yaptırma durumları ile bunu etkileyen faktörlerin belirlenmesi. Gülhane Tıp Dergisi 2006;48:25-9.
2. Parkin DM. “New cases in 2000”. Lancet Oncol 2001;2:533-43.
3. Atasü T, Aydınlı K. Jinekoloji ve Obstetrik pratiğinde kolposkopi, jinekolojik Onkoloji 1996;12:182.
4. Özbay K, Yardım T. Servikal lezyonların değerlendirilmesinde kolposkopi ve PAP smearların etkinliklerinin araştırılması. Jinekoloji ve Obstetrik Dergisi 2005;19:228-32.
5. Ferlay J, Bray F, Pisani P. Globocon 2000: Cancer incidence, mortality and prevalence worldwide. Version 1.0 IARC Cancer Base No. 5 Lyon: IARC Press; 2001.
6. Holowaty P, Miller AB, Rohan T, et al. Natural history of dysplasia of uterine cervix. JNCI 1999;91:252-8.
7. Boman F, Duhamel A, Trench QD, et al. Evaluation of cytological screening for cancers and precancerous lesions of the cervix. Bull Cancer 2003;90:643-7.
8. Rader AE, Rose PG, Rodriguez M, et al. Atypical squamous cells of undetermined significance in women over 55. Comparison with general population and implications for management. Acta Cytol 1999;43:357-62.
9. Quddus MR, Sung CJ, Steinhoff MM, et al. Atypical squamous metaplastic cells: Reproducibility, outcome and diagnostic features on ThinPrep Pap test. Cancer 2001;93:16-22.
10. Maurice Fremont-Smith, James Marino, Bryan Griffin et al. Comparison of the SurePathTM Liquid-Based Papanicolaou Smear with the Conventional Papanicolaou Smear in a Multisite Direct to Vial Study 2004;102:269-79.
11. Supannee Sriamporn, Onanong Kritpetcharat, Pekka Nieminen, et al. Consistency of Cytology Diagnosis for Cervical Cancer between Two Laboratories 2005;6:208-12.
12. Stoler MH, Schiffman M (2001). Atypical Squamous Cells of Undetermined Significance-Low-grade Squamous Intraepithelial Lesion Triage Study (ALTS) Group. Interobserver reproducibility of cervical cytologic and histologic interpretations: Realistic estimates from the ASCUS-LSIL Triage Study. JAMA, 285, 1500-5.
13. Sanjay Gupta, Pushpa Sodhani Sarita Sardana, Kaushik Halder, Veena Singh, Krishan Lal Chachra, Ashok Sehgal. Spectrum of epithelial cell abnormalities of uterine cervix in a cervical cancer screening programme: Implications for resource limited settings 2007:134 Suppl 238-42.