Comparison of carcinoid tumors with the other tumors of appendix
Comparison of carcinoid tumors with the other tumors of appendix
Aim: Carcinoid tumor is the most frequent primary tumor of the appendix which may reach up to 60% of all appendiceal neoplasms.We aimed to evaluate the incidental appendiceal carcinoid tumors following acute appendicitis analyzing the demographics, clinical,laboratory, pathological features and follow-up results of the patients.Material and Methods: We evaluated the patients retrospectively who had been operated for acute appendicitis between January2006 and May 2018 .Results: We found 29 patients with carcinoid tumor among 7122 cases (0.4%) between 2006-2018. Median size of tumors was foundto be 7.5 mm (Min: 0.8, max: 20 mm). While appendectomy was sufficient for 27 of the patients, right hemicolectomy was performedfor 2 cases. When labaratory values were analysed the neutrophil / WBC ratio was significantly higher and lymphocyte count in thestudy group was significantly lower than control group (p < 0.05). The neutrophil / lymphocyte ratio was significantly higher thancontrol group (p < 0.05).Conclusion: Evaluation of laboratory values at admission, histopathological examination of appendiceal specimens, early diagnosisof cancer and performing the appropriate treatment are required for the survival of patients.
___
- 1. Ariyarathenam AV, Nachimutu S, Tang TY, et al. Enterobius
vermicularis infestation of the appendix and management
at the time of laparoscopic appendectomy: case series and
literature review. Int J Surg 2010;8:466-69.
- 2. Wani I, Maqbool M, Amin A, et al. Appendiceal ascariasis in
children. Ann Saudi Med 2010;30:63-6.
- 3. Singh NG, Mannan AA, Kahvic M. Acute amebic appendicitis:
report of a rare case. Indian J Pathol Microbiol 2010;53:767-
68.
- 4. Akbulut S, Tas M, Sogutcu N, et al. Unusual histopathological
findings in appendectomy specimens: A retrospective
analysis and literature review. World J Gastroenterol
2011;17:1961-70.
- 5. Agarwala N, Liu CY. Laparoscopic appendectomy. J Am
Assoc Gynecol Laparosc 2003;10:166-8.
- 6. Tchana-Sato V, Detry O, Polus M, et al. Carcinoid tumor of
appendix: a cosecutive series from 1237 appendectomies.
World J Gastroenterol 2006;12:6699-701.
- 7. Sieren LM, Collins JN, Weireter LJ. et al. The incidence
of benign and malignant neoplasia presenting as acute
appendicitis. Am Surg 2010;76:808-11.
- 8. Shapiro R, Eldar S, Sadot E, et al. The significance of occult
carcinoids in the era of laparoscopic appendectomies. Surg
Endosc 2010;24:2197-99.
- 9. Ma KW, Chia NH, Yeung HW, et al. If not appendicitis,
then what else can it be? A retrospective review of 1492
appendectomies. Hong Kong Med J 2010;16:12-7.
- 10. Khan GM, Grillo IA, Abu-Eshy SA, et al. Pathology of the
appendix. J Natl Med Assoc 2000;92:533-35.
- 11. Hogan MJ. Appendiceal abscess drainage. Tech Vasc Interv
Radiol 2003;6:205-14.
- 12. Okafor PI, Orakwe JC, Chianakwana GU. Management of
appendiceal masses in a peripheral hospital in Nigeria:
review of thirty cases. World J Surg 2003;27:800-3.
- 13. Senapathi PS, Bhattacharya D, Ammori BJ. Early
laparoscopic appendectomy for appendicular mass. Surg
Endosc 2002;16:1783-85.
- 14. Tannoury J, Abboud B. Treatment options of inflammatory
appendiceal masses in adults. World J Gastroenterol
2013;19:3942-50.
- 15. Bucher P, Mathe Z, Demirag A, et al. Appendix tumors in
the era of laparoscopic appendectomy. Surg Endosc
2004;18:1063-66.
- 16. Duzgun AP, Moran M, Uzun S, et al. Unusual findings in
appendectomy specimens: Evaluation of 2458 cases and
review of the literature. Indian J Surg 2004;66:221-26.
- 17. Willemsen PJ, Hoorntje LE, Eddes EH, et al. The need for
interval appendectomy after resolution of an appendiceal
mass questioned. Dig Surg 2002;19:216-20.
- 18. Cakar E, Bayrak S, Bektas H, et al. Carcinoid tumor of the
cecum presenting with acute appendicitis: A case report.
Chirurgia 2015;110:171-74.
- 19. Connor SJ, Hanna GB, Frizelle FA. Appendiceal tumors:
retrospective clinicopathologic analysis of appendiceal
tumors from 7970 appendectomies. Dis Colon Rectum
1998;41:75-80.
- 20. Emre A, Akubulut S, Bozdag Z, et al. Routine histopathologic
examination of appendectomy specimens: Retrospective
analysis of 1255 patients. Int Surg 2013;98:354-62.
- 21. O’Hanlan KA, Fisher DT, O’Holleran MS. 257 incidental
appendectomies during total laparoscopic hystrectomy.
JSLS 2007;11:428-31.
- 22. Machado NO, Chopra P, Pande G. Appendiceal tumourretrospective
clinicopathological analysis. Trop
Gastroenterol 2004;25:36-9.
- 23. Jones AE, Phillips AW, Jarvis JR, et al. The value of
routine histopathological examination of appendicectomy
specimens. BMC Surg 2007;7:17.
- 24. Hatzipantelis E, Panagopoulou P, Sidi-Fragandrea V, et al.
Carcinoid tumors of appendix in children: experience from
a tertiary center in northern Greece. J Pediatr Gastroenterol
Nutr 2010;51:622-25.
- 25. Parker SE, Muir KR, al Sheyyab M, et al. Carcinoid tumors
of the appendix in children 1957-1986: incidence, treatment
and outcome. Br J Surg 1993;80:502-4.
- 26. Goede AC, Caplin ME, Winslet MC. Carcinoid tumour of the
appendix. Br J Surg 2003;90:1317-22.
- 27. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715
carcinoid tumors. Cancer 2003;97:934-59.
- 28. Hermans JJ, Hermans AL, Risseeuw GA, et al. Appendicitis
caused by carcinoid tumor. Radiology 1993;188:71-2.
- 29. De Vita VT, Hellman S, Rosenberg SA. Cancer of the
endocrine system. In Cancer: principles and practice of
oncology. 4th edition. Edited by morton AJ, Levin B, Jensen
RT. Philadelphia: Lippincott Company; 1993;1371.
- 30. Deans GT, Spence RA. Neoplastic lesions of the appendix. Br
J Surg 1995;82:299-306.
- 31. Blair NP, Bugis SP, Turner LJ, et al. Review of the pathologic
diagnoses of 2, 216 appendectomy specimens. Am J Surg
1993;165:618-20.
- 32. Roggo A, Wood WC, Ottinger LW. Carcinoid tumors ofthe
appendix. Ann Surg 1993;217:385-90.