Bora BARUT, Bulent UNAL, Saadet ALAN, Yasin DALDA, Fatih GONULTAS, Koray KUTLUTURK

The predictivity of thyroid fine-needle aspiration biopsy varies depending on the radiologist experience: A retrospective cohort study

Aim: To compare thyroid fine-needle aspiration biopsy with histopathological examination results.Material and Methods: Postoperative histopathological examination results of 361 patients, who were thyroidectomized betweenDecember 2010 and October 2017 in Inonu University Turgut Ozal Medical Center Department of General Surgery and whosepreoperative FNAB registries we could reach were evaluated retrospectively. Biopsies made in external centers were included inpreoperative FNAB results. FNAB results were examined according to Bethesda 2007 in 6 categories: unsatisfactory, benign, atypiaof undetermined significance, follicular lesion-neoplasm or suspicious for a neoplasm, suspicious for malignancy and malignant.Histopathological results of patients with incidental malignancy were presumed benign.Results: Among the 361 patients that were included in the study, 274 were female (75.9%), 87 were male(24.1%). Mean age of thepatients in the benign group was 49.1±12.5 years, and 48.6±13.5 years in the malignant group. It was found that FNAB’s sensitivitywas 83.9 %, specificity was 92.4%, false positive rate was 16.1% and false negative rate was 7.6%.Conclusion: FNAB is reported as the gold standard for preoperative evaluation of thyroid nodules. In our study, however, it wasseen that FNAB was not adequate alone t

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1. Cooper DS, Doherty GM, Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19:1167-214.
2. Frates MC, Benson CB, Charboneau JW, et al. Management of thyroid nodules detected at US: Society of radiologists in ultrasound consensus conference statement. Radiology 2005;237:794-800.
3. Degirmenci B, Haktanir A, Albayrak R, et al. Sonographically guided fine-needle biopsy of thyroid nodules: the effects of nodule characteristicssize on the adequacy of cytological material. ClinRadiol 2007;62:798-803.
4. Gharib H, Goellner JR. Fine-needle aspiration biopsy of the thyroid. Ann Intern Med 1993;118:282-9.
5. Yang J, Schnadig V, Logrono R, et al. Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer 2007;111:306-15.
6. Karataş S, Giray Ö, Peker Ö, ve ark. Thyroid nodüllerinin değerlendirilmesinde bethesda 2007 sınıflamasının klinik sonuçları. Ulusal Cerrahi Dergisi 2009;25:92-6.
7. Herek B, Özcan Ö, Arıkan S, et al. Thyroid fine-needle aspiration biopsy results ile cerrahi patoloji sonuçlarının karşılaştırılması. Endokrinolojide Diyalog Dergisi. 2011;8:105-10.
8. Sclabas GM, Staerkel GA, Shapiro SE, et al. Fine-needle aspiration of the thyroid and correlation with histopathology in a contemporary series of 240 patients. Am J Surg 2003;186:702-9.
9. Langer JE, Baloch ZW, McGrath C, et al. Thyroid nodule fineneedle aspiration. Semin Ultrasound CT MR 2012;33:158- 65.
10. Önver H , Özbey AO , Duymuş M, et al. Tiroit nodüllerinin ultrasonografik, sitolojik ve histopatolojik bulgularının incelenmesi. Kafkas Tıp Bilimleri Dergisi 2013;2:80-7.
11. Roman SA. Endocrine tumors: evaluation of the thyroid nodule. Curr Opin Oncol 2003;15:66-70.
12. Ross DS. Diagnostic approach to and treatment of thyroid nodules. Up To Date. 18/04/2007. http//www.utdol.com/ utd/content/topic.do?topicKey=thyroid /8983&view=print visited on acces date 08.08.2007
13. Papini E, Guglielmi R, Bianchini A, et al. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color Doppler features. J Clin Endocrinol Metab 2002;87:1941-6.
14. Dong Y, Mao M, Zhan W, et al. Size and ultrasound features affecting results of ultrasound-guided fine-needle aspiration of thyroid nodules. J Ultrasound Med 2018;37:1367-77.
15. Guo HQ, Zhang ZH, Zhao H, et al. Factors influencing the reliability of thyroid fine-needle aspiration: analysis of thyroid nodule size, guidance mode for aspiration and preparation method. Acta Cytol 2015;59:169-74.
16. Guille JT, Opoku-Boateng A, Thibeault SL, et al. Evaluation and management of the pediatric thyroid nodule. Oncologist 2015;20:19-27. sampling technique, and needle