Dayo Rotimi OMOTOSO, Winners Prince EHIEMERE, Wasiu Mathew OWONIKOKO

Comparative amelioration of renal histomorphology by ascorbic acid and Camellia sinensis extract in Wistar rats exposed to Lead-induced nephropathy

Aim: To compare the ameliorative effects of ascorbic acid and Camellia sinensis extract on renal histomorphology of lead-inducednephropathic rats.Material and methods: Twenty four rats were randomly grouped into four groups (I–IV) as follows: Normal control group Iadministered distilled water (5 ml/kg), Test control group II administered lead acetate (2 mg/ml), Treated group III administered leadacetate (2 mg/ml) + ascorbic acid (100 mg/kg), Treated group IV administered lead acetate (2 mg/ml) + Camellia sinensis extract (10mg/kg). All administrations were done through oral route and lasted for 30 days.Results: Body and renal tissue weight of study animals were significantly reduced (p < 0.05) in test control relative to normal controlwhile treated groups showed non-significant reduction. Histological examination of renal tissue showed significant prominence ofhistopathological features such as inflammation, necrosis and glomerular congestion in test control group while treated groupsshowed marked reduction.Conclusion: According to the findings of this study, treatment with ascorbic acid or Camellia sinensis extract comparatively exertameliorative effects on lead-induced nephropathy in Wistar rats which in turn culminates into reparative influence on their renalhistomorphology.

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