Erdem Sahin, Yusuf Madendag

Can the 50-g oral glucose tolerance test predict macrosomia and large for gestational age in pregnant women without gestational diabetes?

Aim: The aim of the present study was to evaluate the relationship between the results of the 50-g oral glucose tolerance test (OGTT) and macrosomia and large for gestational age (LGA) in non-gestational diabetes mellitus (GDM) pregnant women. Materials and Methods: Our retrospective study comprised 980 pregnant women18–40 years old, within 24–28 weeks of gestation, and having a singleton pregnancy. GDM was screened using the 50-g OGTT. Patients were divided into three groups according to the OGTT results as follows: (1) 1-h plasma glucose levels >140 mg/dL and normal 100-g OGTT results (false-positive group), (2) 1-h plasma glucose levels between 130 and 139mg/dL, and (3) 1-h plasma glucose levels

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1. Wendland EM, Torloni MR, Falavigna M, et al. Gestational diabetes and pregnancy outcomes-a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria. BMC Pregnancy Childbirth 2012;12:23.
2. Sahin ME, Madendag IC. Evaluation of the prevalence of gestational diabetes mellitus in Kayseri city hospital: A cross-sectional study. J Surg Med 2019;3:715-7.
3. Metzger BE, Contreras M, Sacks D, et al. Hyperglycemia and adverse pregnancy outcomes. New Eng Med 2008;358:1991-2002.
4. Guducu N, Gonenc G, Isci H, et al. The relationship between the risk of the gestational diabetes mellitus with respect to maternal age and initial body mass index. Dicle J Med 2013;40:406-9.
5. Ayaz A, Saeed S, Farooq MU, et al. Gestational diabetes mellitus diagnosed in different periods of gestation and neonatal outcome/Gebelik diyabeti ve yenidogana etkisi. Dicle J Med 2009;36:235.
6. Turgut A, Boran SU, Dolgun ZN, et al. Bir doğumevi gebe izlem polikliniğinde gestasyonel diyabetes mellitus sıklığı. Dicle J Med 2011;38:325-8.
7. Moyer VA. Screening for gestational diabetes mellitus: US Preventive Services Task Force recommendation statement. Annals Int Med 2014;160:414-20.
8. Bulletins—Obstetrics CoP. ACOG Practice Bulletin No. 190: gestational diabetes mellitus. Obstet Gynecol 2018;131:49-64.
9. Stamilio DM, Olsen T, Ratcliffe S, et al. False-positive 1-hour glucose challenge test and adverse perinatal outcomes. Obstet Gynecol 2004;103:148-56.
10. Yee LM, Cheng YW, Liddell J, et al. 50-Gram glucose challenge test: is it indicative of outcomes in women without gestational diabetes mellitus? J Matern Fetal Neonatal Med 2011;24:1102-6.
11. Dudhbhai M, Lim L, Bombard A, et al. Characteristics of patients with abnormal glucose challenge test and normal oral glucose tolerance test results: comparison with normal and gestational diabetic patients. Am J Obstet Gynecol 2006;194:42-5.
12. Tan PC, Ling LP, Omar SZ. The 50-g glucose challenge test and pregnancy outcome in a multiethnic Asian population at high risk for gestational diabetes. Int J Gynecol Obstet 2009;105:50-5.
13. Col Madendag I, Eraslan Sahin M. Evaluation of the relationship between birth weight percentiles and perinatal outcomes in uncomplicated term pregnant women with large birth weight according to gestational age. Cukurova Med J 2020;45:195-9
14. Crowther CA, Hiller JE, Moss JR, et al. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 2005;352:2477- 86.
15. Grotegut CA, Tatineni H, Dandolu V, et al. Obstetric outcomes with a false-positive one-hour glucose challenge test by the Carpenter-Coustan criteria. J Matern Fetal Neonatal Med 2008;21:315-20.
16. Coustan DR, Carpenter MW. The diagnosis of gestational diabetes. Diabetes Care 1998;21:B5.
17. Gumus II, Turhan NO. Are patients with positive screening but negative diagnostic test for gestational diabetes under risk for adverse pregnancy outcome? J Obstet Gynaecol Res 2008;34:359-63.
18. Boriboonhirunsarn D, Sunsaneevithayakul P. Relationship between 50-g glucose challenge test and large for gestational age infants among pregnant women without gestational diabetes. J Obstet Gynaecol 2019;39:141-6.
19. Bevier WC, Fischer R, Jovanovic L. Treatment of women with an abnormal glucose challenge test (but a normal oral glucose tolerance test) decreases the prevalence of macrosomia. Am J Perinatol 1999;16:269-75.