Can monocyte to HDL ratio be used as an inflammatory marker in children with familial mediterranean fever?
Can monocyte to HDL ratio be used as an inflammatory marker in children with familial mediterranean fever?
Aim: Familial Mediterranean fever (FMF); is an auto-inflammatory disease characterized by recurrent fever attacks. Inflammationcontinues even in the attack-free period. Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is an inflammatorymarker that has recently begun to use. The aim of the study was to evaluate the relationship between MHR and FMF in children.Material and Methods: Sixty-two children with FMF in the attack-free period and 60-age and sex-matched- healthy controls includedin the study. Patients divided into subgroups according to their gene mutation type. Monocyte count and HDL-C levels retrieved frommedical records of patients and MHR were calculated from these data.Results: The MHR of individuals were close to each other and there was no statistically significant difference between them ( p>0.05).Twenty-four of the patients had heterozygous, 4 had homozygous, 11 had a compound and 21 had negative mutations. Two of thepatients had no mutation analysis. There was no significant difference between these four groups according to MHR (p=0.348).However, MHR revealed a positive correlation with fibrinogen (r=0.604, p
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