Ersin Kasim ULUSOY, Zeynep DURU, Döndü MELEK ULUSOY

Evaluation of retinal nerve fibre layer and ganglion cell complex thickness with optical coherence tomography in migraine patients

Aim: In this study, we aimed to assess thicknesses of retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients withepisodic migraine and to compare data between from patients with migraine and healthy individuals.Material and Methods: The study included 44 eyes (right) of 44 patients with migraine who presented to neurology outpatientclinic and 54 eyes (right) of healthy individuals. In patients with migraine (with identified subtypes), demographic and clinicalcharacteristics, Visual Analog Scale (VAS) and Migraine Disability Assessment Scale (MIDAS) results were recorded. After detailedophthalmological examination, RNFL and GCC thicknesses were measured with optical coherence tomography (OCT) (Carl ZeissMeditec AG, Jena, Germany, software version: 6.5.0.773). The values obtained were compared between groups. The correlationbetween VAS and MIDAS scores and RNFL and GCC thicknesses were assessed.Results: Mean age was 36.05±8.84 years in migraine group and 32.89±10.89 years in control group. Mean time of follow-up was5.50±3.42 years in patients with migraine. No significant differences were detected in mean RFNL and GCC thicknesses from allquadrants (p>0.05 for all). It was found that VAS and MIDAS scores were negatively correlated to mean RNFL thicknesses in temporaland inferior quadrants (p

PDF

___

1. Vecchia D, Pietrobon D. Migraine: a disorder of brain excitatory-inhibitory balance? Trends Neurosci 2012; 35:507-20.
2. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 2013;33:629-808.
3. Steiner TJ, Stovner LJ, Birbeck GL. Migraine: the seventh disabler. J Headache Pain 2013;14:1.
4. Martinez A, Proupim N, Sanchez M. Retinal nevre fibre layer thickness measurements using optical coherence tomography in migraine patients. Br J Ophthalmol 2008;92:1069-75.
5. Mwanza JC, Oakley JD, Budenz DL, et al. Macular ganglion cell iner plexiform layer: automated detection and thickness thickness reproducibility with spectral domainoptical coherence tomography in glaucoma. Invest Ophthalmol Vis Sci 2011;52:8323-9.
6. Kim KE, Yoo BW, Jeoung JW, et al. Longterm reproducibility of macular ganglion cell analysis in clinically stable glaucoma patients. Invest Ophthalmol Vis Sci 2015;56:4857-64.
7. Marziani E, Pomati S, Ramolfo P, et al. Ganglion layer cells thickness as biologic marker of Alzheimer’s disease. Milan: University of Milan; 2009.
8. Warden V, Hurley AC, Volicer L. Development and psychometric evaluation of the Pain Assessment in Advanced Dementia (PAINAD) scale. J. Am. Med. Dir. Assoc. 2003;4:9-15.
9. Stewart WF, Lipton RB, Whyte J, et al. An international study to assess reliability of the Migraine Disability Assesment (MIDAS) score. Neurology 1999;53:988-4.
10. Ertaş M, Siva A, Dalkara T, et al. Validity and Reliability of the Turkish Migraine Disability Assesment (MIDAS) questionnaire. Headache 2004;44:786-93.
11. Gedikoğlu U, Coşkun O, İnan LE, et al. Validity and realibility of Turkish translation of Migraine Disability Assessment (MIDAS) questionnaire in patients with migraine. Cephalalgia 2005;25:452-6.
12. Ekinci M, Ceylan E, Cagatay HH et al. Retinal nerve fibre layer, ganglion cell layer and choroid thinning in migraine with aura. BMC Ophthalmol 2014;14:75.
13. Gipponi S, Scaroni N, Venturelli E, et al. Reduction in retinal nerve fiber layer thickness in migraine patients. Neurol Sci 2013;34:841-5.
14. Tan FU, Akarsu C, Güllü R: Retinal nerve fiber layer thickness is unaffected in migraine patients. Acta Neurol Scand 2005;112:19-23.
15. Ascaso FJ, Marco S, Mateo J, et al. Optical Coherence Tomography in Patients with Chronic Migraine: Literature Review and Update. Front Neurol 2017;13;8:684.
16. Reggio E, Chisari CG, Ferrigno G, et al. Migraine causes retinal and choroidal structural changes: evaluation with ocular coherence tomography. J Neurol 2017;264:494-502.
17. Colak HN, Kantarcı FA, Tatar MG, et al. Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine. Arq Bras Oftalmol 2016;79:78-81.