Aeroallergens sensitization in an allergic paediatric population of Stone city (Mardin), Turkey: Is it compatible with the previous atmospheric distribution analysis?

Aim: We aimed to determine the distribution of aeroallergen sensitization according to epidermal prick test results and to compare them with the previous atmospheric pollen analysis outcomes Materials and Methods: We retrospectively scanned our patient data between December 2019 and May 2021. The patients with sensitivity to at least one aeroallergen in the epidermal prick test were recruited in the study. Results: A total of 427 patients enrolled in the study and were clinically divided into three groups: 119 (27.9%) had allergic rhinitis, 181 (42.2%) had asthma and 127 (29.7%) had both allergic rhinitis and asthma. Concerning the whole study group, aeroallergen sensitivity was observed most against the grass pollen mixture (79.6%); other common aeroallergens were tree pollen (56.4%), weed pollen mixture (51.5%), house dust mites (16.9%), mold fungi (9.1%). Epidermal prick test pollen distribution was found compatible with previous atmospheric aeroallergen distribution. Conclusions: This is the first study comparing the results of the epidermal prick test with the previous atmospheric pollen measurement results in our country and revealed that they are related.

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1. Tamay Z, Akçay A, Ergin A, Güler N. Prevalence of allergic rhinitis and risk factors in 6- to 7-year old children in Istanbul, Turkey. Turk J Pediatr. 2014 ; 56: 31-40.
2. Gaspar R, de Matos MR, Cortes L, et al. Pollen Proteases Play Multiple Roles in Allergic Disorders.Int J Mol Sci. 2020; 21: 3578.
3. Tham EH, Lee AJ, Bever HV. Aeroallergen sensitization and allergic disease phenotypes in Asia. Asian Pac J Allergy Immunol. 2016; 34: 181-9.
4. Goronfolah L. Aeroallergens, atopy and allergic rhinitis in the Middle East. Eur Ann Allergy Clin Immunol. 2016; 48: 5-21.
5. Cheng L, Chen J, Fu Q, et al. Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis. Allergy Asthma Immunol Res. 2018; 10: 300-53.
6. Höllbacher, B.; Schmitt, A.O.; Hofer, H.; Ferreira, F.; Lackner, P. Identification of proteases and protease inhibitors in allergenic and non-allergenic pollen. Int. J. Mol. Sci. 2017; 18: 1199.
7. Groeme R, Airouche S, Kopecny D. et al. Structural and functional characterization of the major allergen amb a 11 from short ragweed pollen. J. Biol. Chem. 2016; 291:13076-87.
8. Van Cleemput, J, Poelaert K.C.K, Laval K. Et al. Pollens destroy respiratory epithelial cell anchors and drive alpha herpesvirus infection. Sci. Rep. 2019; 9: 4787.
9. Lourenço O, Bosnic-Anticevich S, Costa E, Fonseca JA, Menditto E, Cvetkovski et al. Managing Allergic Rhinitis in the Pharmacy: An ARIA Guide for Implementation in Practice. Pharmacy (Basel). 2020; 8: 85.
10. Hellgren j, Cervin A, Nordling S, Bergman A, Cardell LO. Allergic rhinitis and the common cold: high cost to society. Allergy. 2010; 65: 776-83.
11. Justiz Vaillant AA, Vashisht R, Zito PM. Immediate Hypersensitivity Reactions. 2020 Sep 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan.
12. Chu R, Bajaj P. Asthma Medication in Children. 2020 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020.
13. Sly PD, Boner AL, Björksten B, et al. Early identification of atopy in the prediction of persistent asthma in children. Lancet. 2008; 372: 1100-6.
14. Lucie H, Adriano M, Karl-Christian B, et al. The skin prick test – European standards. Clin Transl Allergy. 2013; 3: 3.
15. Scala E, Villalta D, Meneguzzi G, Brusca I, Cecchi L. Comparison of the performance of Skin Prick and ISAC Tests in the diagnosis of allergy. Eur Ann Allergy Clin Immunol. 2020; 52: 258-67.
16. Tosunoglu A, Saatcioglu G, Bekil S, Malyer H, Bicakci A. Atmospheric pollen spectrum in Stone City, Mardin; the northern border of Mesopotamia/SE-Turkey. Environ Monit Assess. 2018; 190: 635.
17. Bousquet J, Schünemann HJ, Togias A, Bachert C, Erhola M, Hellings PW, et al. Allergic Rhinitis and Its Impact on Asthma Working Group. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol. 2020; 145: 70-80.e3.
18. Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention, 2020. https://ginasthma. org/wp-content/ uploads/2020/06/GINA-2020- report_20_06_04-1-wms.pdf (accessed 1 Oct 2020), Section II.
19. Cecchi L, D’Amato G, Annesi-Maesano I. External exposome and allergic respiratory and skin diseases. J Allergy Clin Immunol. 2018; 141: 846-57.
20. Araújo IMS, Bena MGP, de Brito POL, et al. Socioenvironmental profile of child and adolescents sensitized by house dust mite in northeast of Brazil. Allergol Immunopathol (Madr). 2019; 47: 417-24.
21. Tantilipikorn P, Pinkaew B, Talek K, Assanasen P, Triphoon Suwanwech TS, Bunnag C. Pattern of allergic sensitization in chronic rhinitis: A 19-year retrospective study. Asian Pac J Allergy Immunol. 2020.
22. Visitsunthorn N, Chaimongkol W, Visitsunthorn K, Pacharn P, Jirapongsananuruk O. Great flood and aeroallergen sensitization in children with asthma and/or allergic rhinitis. Asian Pac J Allergy Immunol. 2018; 36: 69-76.
23. Akcakaya N, Cokugras H, Camcioglu Y, Ozdemir M. Skin test hypersensitivity for childhood asthma in Istanbul during a period of 16 years. Allergol Immunopathol (Madr). 2005; 33: 15-9.
24. Yilmaz A, Tuncer A, Sekerel BE, Adalioglu G, Saraçlar Y. Cockroach allergy in a group of Turkish children with respiratory allergies. Turk J Pediatr. 2004; 46: 344-9.
25. Patel S, Meher BR. A review on emerging frontiers of house dust mite and cockroach allergy research. Allergol Immunopathol (Madr). 2016; 44: 580-93.
26. Arrais M, Lulua O, Quifica F, Rosado-Pinto J, Gama JMR, Brito M, Taborda-Barata L. Sensitisation to aeroallergens in relation to asthma and other allergic diseases in Angolan children: a cross-sectional study. Allergol Immunopathol (Madr). 2020; 48: 281-9.
27. Kalpaklioglu AF, Emekçi M, Ferizli AG, Misirligil Z. House dust mite fauna in Turkey. J Investig Allergol Clin Immunol. 1997; 7: 578-82.
28. Dey D, Saha GK, Podder S. A review of house dust mite allergy in India. Exp Appl Acarol. 2019; 78: 1-14.
29. Chu HT, Tran TN, Doyen V, Denis O, Tran TTT, Nguyen TKD, Nguyen HL, Ngo MX, Tran TMH, Corazza F, Bouland C, Hauglustaine JM, Godin I, Michel O. The protective effect of rural life on mite sensitization disappears among urban migrants in the South of Vietnam. World Allergy Organ J. 2019; 12: 100085.
30. Srisuwatchari W, Pacharn P, Jirapongsananuruk O, Visitsunthorn N. Is mold sensitization associated with severe asthma exacerbation in children? Asian Pac J Allergy Immunol. 2020 Oct 17.
31. Beck AF, Huang B, Kercsmar CM, et al. Allergen sensitization profiles in a population-based cohort of children hospitalized for asthma. Ann Am Thorac Soc. 2015; 12: 376-84.
32. Igde M, Artıran F, Sancak R, Ozturk F. Skin Prick Tests Results in the Children from Middle Black Sea Region, Turkey. Turkey Clinics J Pediatr. 2009; 18: 82-90.
33. Alimuddin S, Rengganis I, Rumende CM, Setiati S. Comparison of Specific Immunoglobulin E with the Skin Prick Test in the Diagnosis of House Dust Mites and Cockroach Sensitization in Patients with Asthma and/or Allergic Rhinitis. Acta Med Indones. 2018; 50: 125-31.
34. Uzel A, Capan N, Canbakan S, Yurdakul AS, Dursun B. Evaluation of the relationship between cockroach sensitivity and housedust- mite sensitivity in Turkish asthmatic patients. Respir Med. 2005; 99: 1032-7.
35. Yorgancıoglu A, Kalayci O, Kalyoncu AF, Khaltaev N, Bousquet J. Allergic rhinitis and its impact on asthma update (ARIA 2008) The Turkish perspective. Tuberculosis and Thorax Journal. 2008; 56: 224-31.
36. Harmancı K, Bakırtas A, Türktas I. Sensitization to aeroallergen in preschool in children with respiratory problems in Ankara, Turkey. Turkish Respiratory Journal. 2006; 7: 10-4.
37. Elmas B, Özdemir Ö. Title: Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey. JAREM. 2017; 7: 63-9.
38. Potoglu Erkara I, Osoydan K, Karatas M. Relationship Between Meteorological Factors and Airborne Pollen Grains of Kızıltepe (Mardin), Turkey. Journal of Applied Biological Sciences. 2016; 10: 33-40.
39. Potoglu Erkara, I. Concentrations of airborne pollen grains in Sivrihisar (Eskisehir), Turkey. Environ Monit Assess. 2008; 138: 81-91
40. Koivikk o A, Kupias R, Makinen Y, Pohjola A. Pollen seasons: Forecasts of the most important allergenic plants in Finland. Allergy. 1986; 41: 233-42.
41. Nitiu DS, Mallo CA. Incidence of allergenic pollen of Acer ssp., Fraxinus ssp., and Platanus spp., in the city of La Plata, Argentina: Preliminary results. Aerobiologia. 2002; 18: 65-71.
42. Alan S, Sahin AA, Sarısahin T, et al. The effect of geographical and climatic properties on grass pollen and Phl p 5 allergen release. Int J Biometeorol. 2018; 62: 1325-37.
43. Subiza J, Jerez M, Jiménez JA, et al. Allergenic pollen pollinosis in Madrid. J Allergy Clin Immunol. 1995; 96: 15-23.
44. D Amato M, Cecchi L, Annesi-Maesano I, D Amato G. News on Climate Change, Air Pollution, and Allergic Triggers of Asthma. J Investig Allergol Clin Immunol. 2018; 28: 91-97.
45. Arasi S, Corsello G, Villani A, Pajno GB. The future outlook on allergen immunotherapy in children: 2018 and beyond. Ital J Pediatr. 2018; 44: 80.
46. Ibarrola I, Arilla MC, Martínez A, Asturias JA. Identification of a polygalacturonase as a major allergen (Pla a 2) from Platanus acerifolia pollen. J Allergy Clin Immunol. 2004; 113: 1185-91.
47. Enrique E, Cisteró-Bahíma A, Bartolomé B, et al. Platanus acerifolia pollinosis and food allergy. Allergy. 2002; 57: 351-6.
48. Chhabra N, Houser SM. The surgical management of allergic rhinitis. Otolaryngol Clin North Am. 2011; 44: 779-95, xi.
49. Bousquet J, Schünemann HJ, Samolinski B, et al. Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol. 2012; 130: 1049-62.
50. Jo EJ, Eom JS, Mok J, Kim MH, Lee K, Kim KU, Lee MK, Park HK. Patterns of sensitization to aeroallergens and their effect on airway hyper-responsiveness in Busan, Korea. Asian Pac J Allergy Immunol. 2021; 39: 182-9.