A promising marker in patients with coronary artery ectasia: Uric acid / HDL ratio

A promising marker in patients with coronary artery ectasia: Uric acid / HDL ratio

Aim: Elevated levels of uric acid and low levels of high-density lipoprotein (HDL) cholesterol are associated with cardiovascular events and mortality. We investigated a novel marker, uric acid/HDLratio (UHR), in coronary artery ectasia patients (CAE). Materials and Methods: The present study included 104 patients (58 male, 46 female; mean age, 61±12 years) diagnosed as having isolated CAE and 110 controls (44 male, 66 female; mean age, 60±12 years) whose coronary artery findings were normal as revealed by coronary angiography. Medical records of all the patients were reviewed and the data were collected retrospectively. Baseline characteristics, hematologic and biochemistry parameters were recorded, and we calculated the value of UHRResults: The CAE group had significantly higher values of uric acid (6.48±1.62 vs. 5.37±1.12; p

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  • 1. Swaye PS, Fisher LD, Litwin P, et al. Aneurysmal coronary artery disease. Circulation 1983;67:134-8.
  • 2. Roberts WC. Natural history, clinical consequences, and morphologic features of coronary arterial aneurysms in adults. Am J Cardiol 2011;108:814-21.
  • 3. Isik T, Kurt M, Ayhan E, et al. Relation of red cell distribution width with presence and severity of coronary artery ectasia. Clin Appl Thromb Hemost 2012;18:441-7.
  • 4. Pinar Bermúdez E, López Palop R, Lozano Martínez- Luengas I, et al. Coronary ectasia: prevalence, and clinical and angiographic characteristics. Revista Española de Cardiología Rev Esp Cardiol 2003;56:473- 9.
  • 5. Aboeata AS, Sontineni SP, Alla VM, et al. Coronary artery ectasia: current concepts and interventions. Front Biosci (Elite Ed) 2012;4:300-10.
  • 6. Pahlavan PS, Niroomand F. Coronary artery aneurysm: a review. Clin Cardiol 2006;29:439-43.
  • 7. Kocak MZ, Aktas G, Erkus E, et al. Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev Assoc Med Bras 2019;65:9-15.
  • 8. Ingelsson E, Schaefer EJ, Contois JH, et al. Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. Jama 2007;298:776-85.
  • 9. Anker SD, Doehner W, Rauchhaus M, et al. Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging. Circulation 2003;107:1991-7.
  • 10. Falsetti HL, Carroll RJ. Coronary artery aneurysm: a review of the literature with a report of 11 new cases. Chest 1976;69:630-6.
  • 11. Li J-J, Nie S-P, Qian X-W, et al. Chronic inflammatory status in patients with coronary artery ectasia. Cytokine 2009;46:61-4.
  • 12. Finkelstein A, Michowitz Y, Abashidze A, et al. Temporal association between circulating proteolytic, inflammatory and neurohormonal markers in patients with coronary ectasia. Atherosclerosis 2005;179:353- 9.
  • 13. Rashid S, Gul U, Ali M, et al. Coronary Artery Ectasia: Clinical and Angiographic Features. J Coll Physicians Surg Pak 2018;28:824-8.
  • 14. Swanton R, Thomas ML, Coltart D, et al. Coronary artery ectasia--a variant of occlusive coronary arteriosclerosis. Heart 1978;40:393-400.
  • 15. Jin M, Yang F, Yang I, et al. Uric acid, hyperuricemia and vascular diseases. Frontiers in bioscience: A J and Virtual Library 2012;17:656.
  • 16. Natarajan P, Ray KK, Cannon CP. High-density lipoprotein and coronary heart disease: current and future therapies. J Am Coll Cardiol 2010;55:1283-99.
  • 17. Feingold KR, Grunfeld C. Effect of inflammation on HDL structure and function. Curr Opin Lipidol 2016;27:521- 30.
  • 18. Sudhir K, Ports TA, Amidon TM, et al. Increased prevalence of coronary ectasia in heterozygous familial hypercholesterolemia. Circulation 1995;91:1375-80.
  • 19. Jafari J, Daum A, Hamed JA, et al. Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia. Biomedicines 2019;7:79.
  • 20. Aktas G, Kocak MZ, Bilgin S, et al. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. Aging Male 2019:1-5.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
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