A comparison of L-dopa and clonidine growth hormone stimulation tests in children with short stature

Aim: The purpose of this study was to compare the results of L-dopa and clonidine GH stimulation tests in children with short stature and to identify which of these should be primarily selected. Materials and Methods: The records of 68 patients aged between 2.5 and 16.6 years presenting to the pediatric endocrinology clinic with short stature and undergoing GH stimulation tests between September 2016 and February 2021 were evaluated retrospectively. Cases with GH levels

PDF

___

1. Esen İ, Demirel F, Tepe D, Demir B. Characterıstıcs Of Patıents Who Referred To A Pedıatrıc Endocrınology Outpatıent Clınıc. Turkish J. Pediatr. Dis. 2011;5:133-8
2. Ranke MB. Towards a consensus on the definition of idiopathic short stature. Horm Res 1996;45:64-6.
3. Wit JM, Ranke MB, Kelnar CJH. ESPE classification of paediatric endocrine diagnosis. Horm Res 2007;68:1-120
4. Murray PG, Dattani MT, Clayton PE. Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence. Arch Dis Child. 2016;101(1):96-100.
5. Antoniazzi F, Cavarzere P, Gaudino R. Growth hormone and early treatment. Minerva Endocrinol. 2015;40:129-143
6. Ghigo E, Bellone J, Aimaretti G, et al. Reliability of provocative tests to assess growth hormone secretory status. Study in 472 normally growing children. J Clin Endocrinol Metab. 1996;81:3323-3327
7. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976;51:170 79
8. Hilczer M, Smyczynska J, Lewinski A. Limitations of clinical utility of growth hormone stimulating tests in diagnosing children with short stature. Endocr Regul 2006;40:69-75
9. Grimberg A, Lifshitz F. Worrisome growth. In: Lifshitz F, ed. Pediatric Endocrinology. 5th ed. New York: Infroma Heathcare USA; 2007:1-50
10. Hussein A, Farghaly H, Askar E, et al. Etiological factors of short stature in children and adolescents: experience at a tertiary care hospital in Egypt. Ther Adv Endocrinol Metab. 2017;8(5):75-80
11. Growth Hormone Research S. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. J Clin Endocrinol Metab 2000;85:3990-3
12. Hanew K, Utsumi A. The role of endogenous GHRH in arginine- , insulin-, clonidine- and l-dopa-induced GH release in normal subjects. Eur J Endocrinol. 2002;146:197-202.
13. Biller BM, Samuels MH, Zagar A, et al. Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab. 2002;87:2067-2079
14. Shalet SM, Toogood A, Rahim A, Brennan BM. The diagnosis of growth hormone deficiency in children and adults. Endocr Rev. 1998;19:203-223
15. Moon JS, Lee SY, Nam CM, et al. 2007 Korean National Growth Charts: review of developmental process and an outlook. Korean J Pediatr. 2008;51:1-25
16. Richmond EJ, Rogol AD. Growth hormone deficiency in children. Pituitary 2008;11:115-120
17. Lanes R, Recker B, Fort P, Lifshitz F. Low-dose oral clonidine. A simple and reliable growth hormone screening test for children. American Journal of Diseases of Children 1985;139:87-88.
18. Al-Ruhaily AD, Malabu UH. Growth hormon deficiency sort stature in a third world adult endocrine clinic: usefulness of clonidine test in its diagnosis Indian J Med Sci. 2008;62(4):149- 56.
19. Collu R, Leboeuf G, Letarte J, Ducharme JR. Stimulation of Growth Hormone Secretion by Levodopa-Peopranolol in Children and Adolescents. Pediatrics 1975;56:262-266
20. Petriczko E, Szmit-Domagalska J, Horodnicka-Józwa A, Walczak M. Prognostic value of the L-Dopa and clonidine GH stimulation tests in patients with endogenous growth hormone deficiency - retrospective analysis after discontinuation of treatment - own experience. Pediatr Endocrinol Diabetes Metab. 2009;15(1):13-9.