Topikal antibiyotik kullanımı gerekli mi?

Bu makalede topikal antibiyotik kullanımının gerekli olup olmadığı tartışılmıştır. Özellikle yara ve cerrahi alan infeksiyonlarındaki lokal antibiyotik kullanımına değinilmiştir. Literatür bilgileri ışığında hangi durumlarda lokal antibiyotik kullanımının gerekli, hangi durumlarda gereksiz olduğu değerlendirilmiştir.

Is there any necessity for the usage of topical Antibiotics ?

In this review, the necessity of the usage of topical antibiotics is discussed. Especially the usage of topical antibiotics is mentioned in wound and surgical field infections. In the light of previous studies, the conditions of the necessity of topical antibiotics are evaluated.

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  • 1. Amici G, Russo R, Feriani M et al: Antimicrobial agents for preventing peritonitis in peritoneal dialysis: guideline from the Italian Society of Nephrology, G Ital Nefrol 2007;24 (Suppl 37):125-35.
  • 2. Bowler PG, Duerden BI, Armstrong DG: Wound microbiology and associated approaches to wound management, Clin Microbiol Rev 2001;14(2):244-69 .
  • 3. Boyce ST, Warden GD, Holder IA: Cytotoxicity testing of topical antimicrobial agents on human keratinocytes and fibroblasts for cultured skin grafts, J Burn Care Rehabil 1995;16(2):97-103.
  • 4. Charalambous C, Tryfonidis M, Swindell R, Lipsett AP: When should old therapies be abandoned? A modern look at old studies on topical ampicillin, J Infect 2003;47(3):203-9.
  • 5. Cooper R: A review of the evidence for the use of topical antimicrobial agents in wound care, www.worldwidewounds.com(2004)february/Cooper/Topical-Antimicrobial-Agents.html
  • 6. Diehr S, Hamp A, Jamieson B, Mendoza M: Do topical antibiotics improve wound healing? J Fam Pract 2007;56(2):140-4.
  • 7. Dökmetaş İ: Cerrahide profilaktik antibiyotik kullanı mı, Klimik Derg 2001;14(3):135-9.8. Elaldı N: Cerrahi antimikrobiyal profilaksi, C. Ü. Tıp Fak Derg 2002;24(1):36-44.
  • 9. Friberg O, Svedjeholm R, Kallman J, Soderquist B:Incidence, microbiological findings, and clinical presentation of sternal wound infections after cardiac surgery with and without local gentamicin prophylaxis, Eur J Clin Microbiol Infect Dis 2007;26(2):91-7.
  • 10. Friberg O, Svedjeholm R, Soderquist B, Granfeldt H, Vikerfors T, Kallman J: Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial, Ann Thorac Surg 2005;79(1):153-61.
  • 11. Kamath S, Sinha S, Shaari E, Young D, Campbell AC: Role of topical antibiotics in hip surgery. A prospective randomised study, Injury 2005;36(6):783-7.
  • 12. Khanin AG, Sukhoverov AS: Treatment of purulent postoperative wounds with collagen and immobilised gentamicin, Khirurgiia (Mosk) 1997;(6):44-6.
  • 13. Krukowski ZH, Al-Sayer HM, Reid TM, Matheson NA: Effect of topical and systemic antibiotics on bacterial growth kinesis in generalized peritonitis in man, Br J Surg 1987;74(4):303-6.
  • 14. Moesgaard F, Nielsen ML, Hjortrup A et al: Intraincisional antibiotic in addition to systemic antibiotic treatment fails to reduce wound infection rates in contaminated abdominal surgery. A controlled clinical trial, Dis Colon Rectum 1989;32(1):36-8.
  • 15. Nakamura Y, Daya M: Use of appropriate antimicrobials antimicrobials in wound management, Emerg Med Clin North Am 2007;25(1):159-76.
  • 16. Nigam V, Jaiswal A, Dhaon BK: Local antibiotics:panacea for long term skeletal traction, Injury 2005;36(1):199-202.
  • 17. O’Donnel JA, Tunkel AR: Topical antimicrobials,“Mandell GL, Bennett JE, Dolin R (eds): Mandell,Douglas and Bennett’s Principles and Practice of Infectious Disaese, Sixth ed” kitabında Chapter 35, p.478-89, Churchill and Livingstone Inc., Philadelphia (2005).
  • 18. Odou MF, Muller C, Calvet L, Dubreuil L: In vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin infections, J Antimicrob Chemother 2007;59(4):646-51.19. O’Meara SM, Cullum NA, Majid M, Sheldon TA: Systemic review of antimicrobial agents used for chronic wounds, Br J Surg 2001;88(1):4-21.
  • 20. O’Meara S, Cullum N, Majid M, Sheldon T: Systematic reviews of wound care management: (3) antimicrobial agents for chronic wounds; (4) diabetic foot ulceration, Health Technol Asses 2000;4(21):1-247. http://www.ncchta.org/fullmono/ mon421.pdf
  • 21. Ostermann PA, Seligson D, Henry SL: Local antibiotic therapy for severe open fractures. A review of 1085 consecutive cases, J Bone Joint Surg Br 1995;77(1):93-7.
  • 22. Ozcan AV, Demir M, Onem G et al: Topical versus systemic vancomycin for deep sternal wound infection caused by meticillin resistant Staphylococcus aureus in rodent experimental model, Tex Heart Inst J 2006;33(2):107-10.
  • 23. Price CI, Horton JW, Baxter CR: Liposome encapsulation:a method for enhancing the effectiveness of local antibiotics, Surgery 1994;115(4):480-7.
  • 24. Smoot EC 3rd, Kucan JO, Roth A, Mody N, Debbs N: In vitro toxicity testing for antibacterials agains human keratinocytes, Plast Reconstr Surg 1991;87(5):917-24.
  • 25. Stringel G, Bawdon R, Savrich M, Guertin L, Horton J: Topical and systemic antibiotics in the prevention wound infections, J Pediatr Surg 1989;24(10):1003-6.
  • 26. Strippoli GF, Tong A, Johnson D, Schena FP, Craig JC: Antimicrobial agents for preventing peritonitis in peritoneal dialysis patients, Cochrane Database Syst Rev 2004;18(4):CD004679.
  • 27. Turgut H, Sacar S, Kaleli I et al: Systemic and local antibiotic prophylaxis in the prevention of Staphylococcus epidermidis graft infection, BMC Infect Dis 2005;5:91.
  • 28. van Raaij TM, Visser LE, Vulto AG, Verhaar JA: Acute renal failure after local gentamicin treatment in an infected total knee arthroplasty, J Arthroplasty 2002;17(7):948-50.
  • 29. Vardar-Ünlü G, Ünlü M, Yağmuroğlu A: Klinik örneklerden soyutlanan Staphylococcus aureus ve koagülaz negatif stafilokok izolatlarında mupirosin direnci, ANKEM Derg 2006;20(4);222-5.
  • 30. Yilmaz S, Sumer Z, Kaya S: The in vitro efficiacy of nitrofurazone-rifamycin combination, Ann Microbiol 2002;52:317-21. www.annmicro.unimi.it
ANKEM Dergisi-Cover
  • ISSN: 1301-3114
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1986
  • Yayıncı: Antibiyotik ve Kemoterapi Derneği
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