Ayhan BAŞTAN, Seçkin SALAR, Berkant TOPUZOĞLU

Laktasyon dönemindeki sütçü ineklerde Staphylococcus aureus'a bağlı subklinik mastitislerde uzun süreli antibiyotik tedavisinin bakteriyolojik iyileşme ve somatik hücre sayısı üzerine etkisi

: Bu çalışmada, laktasyon dönemindeki sütçü ineklerde S. aureusun neden olduğu subklinik mastitislerin sağaltımında, uzun süreli antibiyotik kullanımının bakteriyolojik iyileşme ve somatik hücre sayısı (SHS) üzerine etkisi araştırıldı. Çalışmada materyal olarak, subklinik mastitisli ve S. aureus izole edilen toplam 100 adet meme lobu kullanıldı. Subklinik mastitis saptanan meme loblarından tedavi öncesi ve sonrası bakteriyolojik muayene ve somatik hücre sayımı için süt örnekleri alındı. Çalışmada subklinik enfekte ve S. aureus izole edilen meme loblarına antibiyogram sonucuna göre duyarlı olduğu belirlenen amoksisilin+klavulanik asit kombinasyonu meme içi ve intramuskuler (IM) yolla günde bir kez, 7 gün süreyle uygulandı. Tedaviden önce ve tedavi bitiminden 21 gün sonra, aseptik koşullarda ilgili meme loblarından süt örneği alınarak, bakteriyolojik iyileşme oranı ve somatik hücre sayıları belirlendi. Çalışma sonucunda tedavi öncesi ortalama SHS ortanca değeri 300.500 hücre/ml (min-max 1.000-992.000 hücre/ml), tedavi sonrası 183.000 hücre/ml (min-max 2.000-6.574.000 hücre/ml) ve bakteriyolojik iyileşme oranı %66 olarak tespit edildi. Tedavi öncesi ve sonrası ortalama SHS değerleri bakımından farkın istatistiki olarak anlamlı olduğu belirlendi (p0.05). Sonuç olarak, uzun süreli kombine antibiyotik tedavisinin S. aureusa bağlı subklinik mastitislerde bakteriyolojik iyileşme oranında artışa, SHSnda ise azalmaya yol açtığı tespit edildi.

The effect of long term antibiotic treatment on bacteriological cure and somatic cell count at subclinical mastitis due to Staphylococcus aureus in lactating dairy cows

In this study, the effect of extended antibiotic treatment on bacteriological cure and SCC in lactating dairy cows suffering from subclinical mastitis due to S. aureus was investigated. As material, a total of 100 S. aureus isolated subclinically infected udder lobes were used. Before and after the treatment, milk samples were taken from subclinically infected udder lobes for bacteriological examination and somatic cell counting. Amoxicillin+clavulanic acid combination, determined as sensitive by the antibiogram, was administered both intramammarily and intramuscularly once a day during 7 days to udder lobes infected with S. aureus subclinically. Before treatment and also on 21th day after treatment milk samples were taken aseptically in order to determine bacteriological cure rate and somatic cell counts. At the end of the study, mean SCCs before and after treatment were determined as 300.500 cell/ml (min-max 1.000-992.000 cell/ml) and 183.000 cell/ml (min-max 2.000-6.574.000 cell/ml), respectively. Additionally, the bacteriological cure rate was %66. The difference with regard to mean SCC values between the two samplings was statistically significant (p

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