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Effects of Aroclor 1254 and vitamin E on arginase activity in adult, pregnant rats and their offsprings

Bu çalışmada yetişkin, gebe rat ve yavrularında arginaz aktivitesi üzerine Aroclor 1254'ün etkisi ve vitamin E'nin koruyucu rolü araştırıldı. Toplam 90 Sprague-Dawley rat 30 yetişkin, 30 gebe ve 30 yavru olmak üzere üç ana gruba ayrıldı. Gebelik süresince (20 gün) subkutan olarak Aroclor 1254 (2 mg/kg/gün) tek başına veya vitamin E (50 mg/kg/gün) ile birlikte ve kontrol grubuna serum fizyolojik uygulandı. Dişi ratlar ve onların yavrularının (her gruptan 10 yavru) karaciğerinde arginaz aktivitesi analiz edildi. Aroclor 1254'e maruz kalan yetişkin ratların karaciğer arginaz aktivitesinde anlamlı bir artış (p

Aroclor 1254 ve vitamin E'nin yetişkin, gebe rat ve yavrularında arginaz aktivitesi üzerine etkileri

This study examined the effect of Aroclor 1254 on arginase activity and protective role of vitamin E among adult rats, pregnant rats and their offsprings. Totally 90 Sprague-Dawley rats were divided into three main groups as 30 pregnant, 30 adult and 30 offsprings (pups of the pregnant rats) based on the treatments administered during the pregnancy period (20 days) with subcutaneous daily injections of Aroclor 1254 (2 mg/kg/day) alone or associated with vitamin E (50 mg/kg/day) or normal saline in controls. Female rats and their offsprings (10 offsprings per groups) were analyzed in terms of the arginase activity in liver. A statistically significant increase was determined in liver arginase activity of adult rats exposed to Aroclor 1254 (p

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