Cem ERDOĞAN, Lütfü HANOĞLU, Deniz KIZILASLAN, Özge ARICI DÜZ, Nesrin Helvacı YILMAZ, Eren TOPLUTAŞ

Yoğun Bakımda Takip Edilen Hipoksik Ensefalopati Hastalarında Prognozu Etkileyen Faktörler

Amaç: Kardiyak arrest sonrasında gelişen hipoksik ensefalopati (HE) ciddi nörolojik sekel ve ölüme neden olabilen bir klinik tablodur. HE’li hastalardaprognozu belirlemek, takip ve uzun vadede geliştirilecek tedaviler açısından önemlidir. Bu çalışmada amacımız HE tanısı almış hastalarda yaş,cinsiyet, hipotermi uygulamasının, beyin manyetik rezonans görüntüleme de (MRG) lezyon yerinin, epileptik nöbet varlığının ve elektroensefalografi(EEG) bulgularının prognoz üzerine etkilerini araştırmaktır.Gereç ve Yöntem: Erişkin yoğun bakım ünitesi hasta kayıtları retrospektif olarak incelendi. HE tanısı almış 194 hasta çalışmaya dahil edildi. Hastaların118’i erkek (%60,8), 76’sı (%39,2) kadındı. Sağ kalanlar ve eksitus olanlar belirlendi. Hipotermi uygulananlar, beyin MRG bulguları (kortikal ve/veyasubkortikal lezyon), epileptik nöbet varlığı (miyoklonik, jeneralize, fokal) ve EEG bulguları (epileptik aktivite, status, jeneralize yavaşlama) kaydedildi.Bulgular: Yaş ortalaması 59,46±1,71 (18-89) idi. Yetmiş altı (%39,2) hastaya hipotermi uygulandı. Yüz yedi (%55,2) hasta eksitus oldu. Yaşlı hastalarıneksitus olma oranı anlamlı olarak daha yüksekti (p

Factors Affecting Prognosis in Hypoxic Encephalopathy Patients Followed-up in Intensive Care Unit

Objectives: Hypoxic encephalopathy (HE) after cardiac arrest is a clinical condition that can cause severe neurological sequelae and death. It is important to determine the prognosis in patients with HE for follow up and developing future treatments in the long term. Our aim was to investigate the effects of age, gender, hypothermia, lesion site in brain magnetic resonance imaging (MRI), seizure and electroencephalography (EEG) findings on prognosis in patients with the diagnosis of HE. Materials and Methods: The data of the adult intensive care unit was evaluated retrospectively. A total of 194 patients with HE were included into the study. One hundred and eighteen (60.8%) of the patients were male and 76 (39.2%) were female. The survivors and those who died were identified. Hypothermia therapy, brain MRI findings (cortical and/or subcortical lesion), presence of seizures (myoclonic, generalized, focal) and EEG findings (epileptic activity, status, generalized slowing) were recorded. Results: The mean age was 59.46±1.71 (18-89). Seventy-six (39.2%) patients underwent hypothermia. One hundred and seven (55.2%) patients died. The rate of exitus in elderly patients was significantly higher (p

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