Didem Sezgin ÖZCAN, Özgür Ulaş ÖZCAN, Cemile Sevgi POLAT, Çetin EROL, Nil ÖZYÜNCÜ

Ventricular Arrhythmia With Cessation of Infliximab in a Patient With Ankylosing Spondylitis

İnfliksimab dirençli ankilozan spondilit (AS) tedavisinde endikasyonu bulunan bir anti-tümör nekroz faktör alfa ajanıdır. İnfliksimabın erken kesilmesi sonucu ventriküler tasikardi gelisen bir hasta sunuyoruz. İnfliksimab tedavisinin tekrar baslanmasıyla ventriküler tasikardi tekrarlamamıstır. Bu vaka takdimi AS hastalarında inflamasyonun, subklinik ventriküler tutulumun potansiyel olarak ölümcül aritmilere yol açabilmesi nedeniyle, baskılanmasının önemini vurgulamaktadır.

Ankilozan Spondilitli Bir Hastada İnfliksimabın Kesilmesiyle Olusan Ventriküler Aritmi

Infliximab is an anti-tumor necrosis factor alpha agent, which is indicated for the treatment of resistant ankylosing spondylitis (AS). We presented a patient with AS who developed ventricular tachycardia after premature cessation of infliximab. Ventricular tachycardia did not recur after restarting of infliximab treatment. This case report remarked the significance of the suppression of inflammation in AS since the subclinical ventricular involvement may potentially lead to the fatal arrhythmias.

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